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Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature

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Abstract

Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity.

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Acknowledgements

PAB and BRJ acknowledge to CSIR, New Delhi, for Research Fellowship.

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Authors and Affiliations

  1. Chemical Engineering & Process Development Division, CSIR-National Chemical Laboratory, Pune, 411008, India

    Pralhad A. Burate, Balasaheb R. Javle, Pranjal H. Desale & Anil K. Kinage

  2. Academy of Scientific & Innovative Research (AcSIR), New Delhi, 110025, India

    Pralhad A. Burate, Balasaheb R. Javle & Anil K. Kinage

Authors
  1. Pralhad A. Burate
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  2. Balasaheb R. Javle
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  3. Pranjal H. Desale
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  4. Anil K. Kinage
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Correspondence to Anil K. Kinage.

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Burate, P.A., Javle, B.R., Desale, P.H. et al. Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature. Catal Lett 149, 2368–2375 (2019). https://doi.org/10.1007/s10562-019-02840-5

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  • DOI: https://doi.org/10.1007/s10562-019-02840-5

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