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A simple, efficient, and green protocol for Knoevenagel condensation in a cost-effective ionic liquid 2-hydroxyethlammonium formate without a catalyst

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Abstract

Knoevenagel condensation of aromatic aldehydes with active methylene compounds such as malononitrile, ethylcyanoacetate, and cyanoacetamide proceeded very smoothly in reusable and cheap ionic liquid 2-hydroxyethylammonium formate at room temperature in the absence of a catalyst. Compared to other reported ionic liquids, the ionic liquid 2-hydroxyethylammonium formate shows better potential in the applications on the industrial scale with its low cost and viscosity.

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Authors and Affiliations

  1. School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, 317000, China

    Anguo Ying, Huading Liang, Renhua Zheng, Changhua Ge, Huajiang Jiang & Chenglin Wu

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  1. Anguo Ying
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  2. Huading Liang
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  3. Renhua Zheng
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  4. Changhua Ge
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  5. Huajiang Jiang
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  6. Chenglin Wu
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Correspondence to Anguo Ying.

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Ying, A., Liang, H., Zheng, R. et al. A simple, efficient, and green protocol for Knoevenagel condensation in a cost-effective ionic liquid 2-hydroxyethlammonium formate without a catalyst. Res Chem Intermed 37, 579–585 (2011). https://doi.org/10.1007/s11164-011-0300-4

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