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Bulky N-acyl-pyridylbenzamidine Ligands for Palladium Catalyzed Suzuki–Miyaura Reaction

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Abstract

In this letter, a series of bulky N-acyl-pyridylbenzamidine ligands were synthesized and characterized. Under the optimized reaction conditions, these bulky ligands were applied to catalyze Suzuki–Miyaura reactions of various aryl bromides and chlorides. The desired biaryl products were obtained in good to high yields.

Graphical Abstract

A series of bulky N-acyl-pyridylbenzamidine ligands were synthesized and employed in palladium catalyzed Suzuki–Miyaura reactions. This catalytic system showed effective catalytic efficiency towards an array of various aryl bromides and chlorides under aerobic conditions.

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Acknowledgements

We are sincerely grateful for the financial support from the National Natural Science Foundation of China (No. 21004014).

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Zhongshan, Guangdong, 528458, People’s Republic of China

    Cheng Tan, Feng-Shou Liu, Dong-Sheng Shen, Tao Cheng & Zong-Zhou Zhou

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  1. Cheng Tan
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  2. Feng-Shou Liu
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  3. Dong-Sheng Shen
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  4. Tao Cheng
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  5. Zong-Zhou Zhou
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Correspondence to Feng-Shou Liu or Dong-Sheng Shen.

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Tan, C., Liu, FS., Shen, DS. et al. Bulky N-acyl-pyridylbenzamidine Ligands for Palladium Catalyzed Suzuki–Miyaura Reaction. Catal Lett 141, 1332–1337 (2011). https://doi.org/10.1007/s10562-011-0625-z

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