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Irradiation sterilization used for allogenetic tendon: a literature review of current concept

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Abstract

Tendon injury is a very common type of sports trauma, and its incidence has increased over the past decades. Surgical reconstruction with tendon allograft has been increasingly used to restore the motor function and stability of the injured site. However, the risk of disease transmission caused by allogeneic tendon transplantation has been a major problem for tissue bank researchers and clinicians. In order to eliminate the risk of disease transmission, a process of terminal sterilization is necessary. Ionizing irradiation, including gamma irradiation and electron beam irradiation is the most commonly used method for the terminal sterilization, which has been widely proved to be able to effectively inactivate the contained pathogens. Nevertheless, some accompanying damage to the mechanical and histological properties of collagen fibers in tendons will be caused. Therefore, more and more studies have begun to pay attention to the protective effect of radiation protection agents, including the radical scavengers and cross-linking agents, in the irradiation sterilization of allogeneic tendons.

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Acknowledgements

I would like to express my special thanks to my partners for the encouragement and support they gave me during my study.

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  1. Graduate School, Tianjin Medical University, Tianjin, 300070, China

    Xionggang Yang, Jiangtao Feng & Feng Wang

  2. Department of Orthopedic Oncology, Tianjin Hospital, Tianjin, 300211, China

    Yongcheng Hu

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  1. Xionggang Yang
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Yang, X., Feng, J., Wang, F. et al. Irradiation sterilization used for allogenetic tendon: a literature review of current concept. Cell Tissue Bank 20, 129–139 (2019). https://doi.org/10.1007/s10561-019-09756-9

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