Abstract
As banked human tissues are not widely available, the development of new non-destructive and contactless techniques to evaluate the quality of allografts before distribution for transplantation is very important. Also, tissues will be processed accordingly to standard procedures and to minimize disease transmission most tissue banks will include a decontamination or sterilization step such as ionizing radiation. In this work, we present a new method to evaluate the internal structure of frozen or glycerol-processed human cartilages, submitted to various dosis of irradiation, using the total optical attenuation coefficient retrieved from optical coherence tomography (OCT) images. Our results show a close relationship between tensile properties and the total optical attenuation coefficient of cartilages. Therefore, OCT associated with the total optical attenuation coefficient open a new window to evaluate quantitatively biological changes in processed tissues.
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Acknowledgments
We would acknowledge the International Atomic Energy Agency (IAEA), the Comissão Nacional de Energia Nuclear (CNEN), and the Fundação de Amparo à Pesquisa do Estado de São Paulo (Fapesp) (Grant No. 2008/10437-9) for supporting this work.
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Martinho Junior, A.C., Freitas, A.Z., Raele, M.P. et al. Dependence of optical attenuation coefficient and mechanical tension of irradiated human cartilage measured by optical coherence tomography. Cell Tissue Bank 16, 47–53 (2015). https://doi.org/10.1007/s10561-013-9413-x
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DOI: https://doi.org/10.1007/s10561-013-9413-x