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Bone tissue, lyophilized and stored at room temperature for 15 days or more, is not capable of transmitting HIV, HCV or HBV

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Abstract

Over the past 57 years, 17 recipients of frozen bone have been infected with: HIV (Centers for Disease Control and Prevention in Morb Mortal Wkly Rep MMWR 37(39):597–599, 1988; Li et al. in J Formos Med Assoc 100(5):350–351, 2001; Simonds et al. in NEJM 326(11):726–732, 1992; Schratt et al. in Unfallchirurg 99(9):679–684, 1996); HCV (Eggen and Nordbo in NEJM 326(6):411, 1992; Conrad et al. in J Bone Joint Surg Am 77:214–224, 1995; Trotter in J Bone Joint Surg Am 851(11):2215–2217, 2003; Tugwell et al. in Ann of Internal Med 143(9):648–654, 2005); or HBV (Shutkin in J Bone Joint Surg Am 36:160–162, 1954). However, bone, lyophilized and stored at room temperature, has never transmitted these viral diseases. A literature review was undertaken to determine whether there is any evidence that lyophilized bone is capable of transmitting HIV, HCV and HBV.

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Acknowledgments

Special thanks to Professor Glyn O. Phillips for his encouragement and invitation to present this paper in outline form in Kuala Lumpur at the 2008 5th World Congress On Tissue Banking & 12th International Conference Of The Asia Pacific Association Of Surgical Tissue Banks, and, to Professor Axel Pruss with whom I enjoyed a constructive dialogue immediately after the presentation.

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  1. Nelson Levine de Luca & Horst, LLC, 518 E. Township Line Road, Blue Bell, PA, 19422, USA

    John T. Salvucci

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  1. John T. Salvucci
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Correspondence to John T. Salvucci.

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Mr. Salvucci is a member of the United States law firm, Nelson Levine de Luca & Horst, LLC. Previously, while affiliated with another United States law firm, he defended a tissue processor in multidistrict litigation.

All references to bone tissue allografts is abbreviated by the use of the word “bone”.

The use of the word “lyophilized” will designate biologic products that have been freeze-dried, without the addition of cryopreservative agents, and thereafter stored at room temperature.

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Salvucci, J.T. Bone tissue, lyophilized and stored at room temperature for 15 days or more, is not capable of transmitting HIV, HCV or HBV. Cell Tissue Bank 12, 99–104 (2011). https://doi.org/10.1007/s10561-010-9173-9

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  • DOI: https://doi.org/10.1007/s10561-010-9173-9

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