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Mitochondrial PINK1—A Novel Cardioprotective Kinase?

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References

  1. Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream.2007;129:1261–74.

  2. Hausenloy DJ, Yellon DM. Survival kinases in ischaemic preconditioning and postconditioning. Cardiovasc Res. 2006;70:240–53.

    Article  PubMed  CAS  Google Scholar 

  3. Li L, Ross AH. Why is PTEN an important tumor suppressor? J Cell Biochem. 2007;102:1368–74.

    Article  PubMed  CAS  Google Scholar 

  4. Mocanu MM, Yellon DM. PTEN, the Achilles’ heel of myocardial ischaemia/reperfusion injury? Br J Pharmacol. 2007;150:833–8.

    Article  PubMed  CAS  Google Scholar 

  5. Mocanu MM, Field DC, Yellon DM. A potential role for PTEN in the diabetic heart. Cardiovasc Drugs Ther. 2006;20:319–21.

    Article  PubMed  Google Scholar 

  6. Siddall HK, Warrell CE, Yellon DM. Mocanu MM Ischaemia–reperfusion injury and cardioprotection: Investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency. Basic Res Cardiol. 2008 July 5 (in press)

  7. Unoki M, Nakamura Y. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene. 2001;20:4457–65.

    Article  PubMed  CAS  Google Scholar 

  8. Lin W, Kang UJ. Characterization of PINK1 processing, stability, and subcellular localization. J Neurochem. 2008;106:464–74.

    Article  PubMed  CAS  Google Scholar 

  9. Pridgeon JW, Olzmann JA, Chin LS, Li L. PINK1 Protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1. PLoS Biol. 2007;5:e172.

    Article  PubMed  CAS  Google Scholar 

  10. Deng H, Jankovic J, Guo Y, Xie W, Le W. Small interfering RNA targeting the PINK1 induces apoptosis in dopaminergic cells SH-SY5Y. Biochem Biophys Res Commun. 2005;337:1133–8.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. The Hatter Cardiovascular Institute, University College London Hospital and Medical School, 67 Chenies Mews, London, WC1E 6HX, UK

    Hilary K. Siddall, Clare E. Warrell, Sean M. Davidson, Mihaela M. Mocanu & Derek M. Yellon

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  1. Hilary K. Siddall
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  2. Clare E. Warrell
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  3. Sean M. Davidson
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  4. Mihaela M. Mocanu
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  5. Derek M. Yellon
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Correspondence to Derek M. Yellon.

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Siddall, H.K., Warrell, C.E., Davidson, S.M. et al. Mitochondrial PINK1—A Novel Cardioprotective Kinase?. Cardiovasc Drugs Ther 22, 507–508 (2008). https://doi.org/10.1007/s10557-008-6136-5

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  • DOI: https://doi.org/10.1007/s10557-008-6136-5

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