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A Potential Role for PTEN in the Diabetic Heart

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References

  1. Kondo T, Kahn CR. Altered insulin signaling in retinal tissue in diabetic states. J Biol Chem 2004;279(36):37997–8006.

    Article  PubMed  CAS  Google Scholar 

  2. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway. Cardiovasc Res 2004;61(3):448–60.

    Article  PubMed  CAS  Google Scholar 

  3. Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z. The mechanism of action of the tumour suppressor gene PTEN. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2003;147(1):19–25.

    PubMed  CAS  Google Scholar 

  4. Oudit GY, Sun H, Kerfant BG, Crackower MA, Penninger JM, Backx PH. The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease. J Mol Cell Cardiol 2004;37(2):449–71.

    Article  PubMed  CAS  Google Scholar 

  5. Cai Z, Semenza GL. PTEN activity is modulated during ischemia and reperfusion: involvement in the induction and decay of preconditioning. Circ Res 2005;97(12):1351–9.

    Article  PubMed  CAS  Google Scholar 

  6. Tsang A, Hausenloy DJ, Mocanu MM, Carr RD, Yellon DM. Preconditioning the diabetic heart: the importance of Akt phosphorylation. Diabetes 2005;54(8):2360–4.

    PubMed  CAS  Google Scholar 

  7. Mensah K, Mocanu MM, Yellon DM. Failure to protect the myocardium against ischemia/reperfusion injury after chronic atorvastatin treatment is recaptured by acute atorvastatin treatment: a potential role for phosphatase and tensin homolog deleted on chromosome ten? J Am Coll Cardiol 2005;45(8):1287–91.

    Article  PubMed  CAS  Google Scholar 

  8. Teresi RE, Shaiu CW, Chen CS, Chatterjee VK, Waite KA, Eng C. Increased PTEN expression due to transcriptional activation of PPARgamma by Lovastatin and Rosiglitazone. Int J Cancer 2006;118(10):2390–8.

    Article  PubMed  CAS  Google Scholar 

  9. Butler M, McKay RA, Popoff IJ, et al. Specific inhibition of PTEN expression reverses hyperglycemia in diabetic mice. Diabetes 2002;51(4):1028–34.

    PubMed  CAS  Google Scholar 

  10. Kushner JA, Simpson L, Wartschow LM, et al. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. J Biol Chem 2005;280(47):39388–93.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Derek M. Yellon.

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Mocanu, M.M., Field, D.C. & Yellon, D.M. A Potential Role for PTEN in the Diabetic Heart. Cardiovasc Drugs Ther 20, 319–321 (2006). https://doi.org/10.1007/s10557-006-8876-4

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