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Linking the Cardiomyocyte Circadian Clock to Myocardial Metabolism

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Abstract

Introduction

The energetic demands imposed upon the heart vary dramatically over the course of the day. In the face of equally commanding oscillations in the neurohumoral mileu, the heart must respond both rapidly and appropriately to its diurnal environment, for the survival of the organism. A major response of the heart to alterations in workload, nutrients, and various neurohumoral stimuli is at the level of metabolism. Failure of the heart to achieve adequate metabolic adaptation results in contractile dysfunction.

Discussion

Substantial evidence is accumulating which suggests that a transcriptionally based timekeeping mechanism known as the circadian clock plays a role in mediating myocardial metabolic rhythms. Here, we provide an overview of our current knowledge regarding the interplay between the circadian clock within the cardiomyocyte and myocardial metabolism. This includes a particular focus on circadian clock mediated regulation of endogenous energy stores, as well as those mechanisms orchestrating circadian rhythms in metabolic gene expression.

Conclusion

An essential need to elucidate fully the functions of this molecular mechanism in the heart remains.

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Acknowledgements

We would like to thank Michael Moore for technical support regarding the data presented in Fig. 2. This work was supported by the National Heart, Lung, and Blood Institute grant HL074259.

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  1. Department of Pediatrics, USDA/ARS Children’s Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX, 77030, USA

    David J. Durgan & Martin E. Young

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Durgan, D.J., Young, M.E. Linking the Cardiomyocyte Circadian Clock to Myocardial Metabolism. Cardiovasc Drugs Ther 22, 115–124 (2008). https://doi.org/10.1007/s10557-008-6086-y

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