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The importance of 15-lipoxygenase inhibitors in cancer treatment

Cancer and Metastasis Reviews volume 37, pages 397–408 (2018)Cite this article

Abstract

Cancer-targeted therapy is an expanding and successful approach in treatment of many types of cancers. One of the main categories of targeted therapy is use of small molecule inhibitors. 15-Lipoxygenase (15-LOX) is an enzyme which reacts with polyunsaturated fatty acids and produces metabolites that are implicated in many important human diseases, such as cancer. Considering the role of 15-LOX (mainly 15-LOX-1) in the progression of some cancers, the discovery of 15-LOX inhibitors could potentially lead to development of novel cancer therapeutics and it can be claimed that 15-LOX inhibitors might be suitable as chemotherapy agents in the near future. This article reviews relevant publications on 15-LOX inhibitors with focus on their anticancer activities in vitro and in vivo. Many 15-LOX inhibitors have been reported for which separate studies have shown their anticancer activities. This review paves the way to further explore the mechanism of their antiproliferative effects via 15-LOX inhibition.

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Affiliations

  1. Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran

    Ala Orafaie & Maryam Moghaddam Matin

  2. Novel Diagnostics and Therapeutics Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran

    Maryam Moghaddam Matin

  3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Hamid Sadeghian

  4. Department of Laboratory Sciences, School of Paramedical Sciences, Mashhad University of Medical Sciences, Mashhad, 91857-63788, Iran

    Hamid Sadeghian

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  1. Ala Orafaie
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  2. Maryam Moghaddam Matin
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  3. Hamid Sadeghian
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Correspondence to Hamid Sadeghian.

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Orafaie, A., Matin, M.M. & Sadeghian, H. The importance of 15-lipoxygenase inhibitors in cancer treatment. Cancer Metastasis Rev 37, 397–408 (2018). https://doi.org/10.1007/s10555-018-9738-9

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Keywords

  • 15-LOX
  • Coumarin
  • Flavonoid
  • Catechol
  • Azine
  • Cannabidiol