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Role of MTA1 in head and neck cancers

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Abstract

Head and neck cancers usually originate in the squamous cells that line the inner mucosal surfaces of the oral and the neck region. These cancers follow multifocal steps for progression that include risk of developing metastasis. Although therapeutics has advanced in the past decades, head and neck cancers continue to cause much morbidity and mortality. Even with the promising effect of targeted therapies, there is a need for a better evaluation of patients with head and neck cancers. Metastasis-associated tumour antigen 1 (MTA1), a chromatin modifier, is found as an integral part of nucleosome remodelling and histone deacetylation (NuRD) complex. MTA1 is a biomarker for several solid tumours, and the overexpression of which have been documented in various cancers such as breast, ovarian, colon, prostrate etc. Interestingly also, a set of head and neck cancers shows MTA1 overexpression. However, recent evidences from clinical data raise a critical question on the role of MTA1 in head and neck cancers. This calls for a detailed review to the role of MTA1 in oral cancer. This review gives a brief account on the existing biological and molecular data in the context of head and neck cancer invasion and metastasis in relation to MTA1.

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References

  1. Ferlay, J., Shin, H., Bray, F., Forman, D., Mathers, C., & Parkin, D. M. (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. International Journal of Cancer, 127, 2893–2917.

    Article  CAS  Google Scholar 

  2. Nair, S., & Pillai, M. R. (2005). Human papillomavirus and disease mechanisms: relevance to oral and cervical cancers. Oral Diseases, 11, 350–359.

    Article  CAS  PubMed  Google Scholar 

  3. Brumbaugh, J., Ferris, R. L., & Hu, S. (2011). HPV and EBV in head and neck cancer. In: Bernier J (Ed.) Head and neck cancer: Multimodality management. Springer Publisher, New York, 121–134.

  4. Ang, K. K., Harris, J., Wheeler, R., Weber, R., Rosenthal, D. I., Nguyen-Tân, P. F., Westra, W. H., Chung, C. H., Jordan, R. C., Lu, C., Kim, H., Axelrod, R., Silverman, C. C., Redmond, K. P., & Gillison, M. L. (2010). Human papillomavirus and survival of patients with oropharyngeal cancer. New England Journal of Medcine, 363, 24–35.

    Article  CAS  Google Scholar 

  5. Bernier, J., & Cooper, J. S. (2005). Chemoradiation after surgery for high-risk head and neck cancer patients: how strong is the evidence? The Oncologist, 10, 215–224.

    Article  PubMed  Google Scholar 

  6. Boscolo-Rizzo, P., Maronato, F., Marchiori, C., Gava, A., & Da Mosto, M. C. (2008). Long-term quality of life after total laryngectomy and postoperative radiotherapy versus concurrent chemoradiotherapy for laryngeal preservation. Laryngoscope, 118, 300–306.

    Article  PubMed  Google Scholar 

  7. Kotwall, C., Sako, K., Razack, M. S., Rao, U., Bakamjian, V., & Shedd, D. P. (1987). Metastatic patterns in squamous cell cancer of the head and neck. The American Journal of Surgery, 154, 439–442.

    Article  CAS  Google Scholar 

  8. Law, J. Y., Chen, S. A., Gerber, D. E., Hughes, R. S., Madrigales, A., Myers, L. L., Nedzi, L. A., Sumer, B. D., Truelson, J., Yordy, J. S., Zhu, H., & Khan, S. A. (2014). Patterns of distant metastases in HPV-positive head and neck squamous cell carcinoma. Journal of Clinical Oncology, 32.

  9. O’Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., et al. (1997). Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell, 88, 277–285.

    Article  PubMed  Google Scholar 

  10. Homer, J. J., Greenman, J., & Stafford, N. D. (2002). Circulating angiogenic cytokines as tumor markers and prognostic factors in head and neck squamous cell carcinoma. Clinical Otolaryngology & Allied Sciences, 27, 7.

    Google Scholar 

  11. Berchem, G., Glondu, M., Gleizes, M., Brouillet, J. P., Vignon, F., Garcia, M., & Liaudet-Coopman, E. (2002). Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis. Oncogene, 21, 5951–5955.

    Article  CAS  PubMed  Google Scholar 

  12. Wolf, M., Clark-Lewis, I., Buri, C., Langen, H., Lis, M., & Mazzucchelli, L. (2003). Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer. American Journal of Pathology, 162, 1183–1190.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Vigneswaran, N., Zhao, W., Dassanayake, A., Muller, S., Miller, D. M., & Zacharias, W. (2000). Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancer. Human Pathology, 31, 931–937.

    Article  CAS  PubMed  Google Scholar 

  14. Patel, B. P., Shah, S. V., Shukla, S. N., Shah, P. M., & Patel, P. S. (2007). Clinical significance of MMP-2 and MMP-9 in patients with oral cancer. Head and Neck, 29, 564–572.

    Article  PubMed  Google Scholar 

  15. Sauter, E. R., Nesbit, M., Watson, J. C., Klein-Szanto, A., Litwin, S., & Herlyn, M. (1999). Vascular endothelial growth factor is a marker of tumor invasion and metastasis in squamous cell carcinomas of the head and neck. Clinical Cancer Research, 5, 775–782.

    CAS  PubMed  Google Scholar 

  16. Bock, J. M., Sinclair, L. L., Bedford, N. S., Jackson, R. E., Lee, J. H., & Trask, D. K. (2008). Modulation of cellular invasion by VEGF-C expression in squamous cell carcinoma of the head and neck. Archives of Otolaryngology - Head and Neck Surgery, 143, 355–362.

    Article  Google Scholar 

  17. Hong, D.-Y., Lee, B.-J., Lee, J.-C., Choi, J.-S., & Wang, S.-G. (2009). Expression of VEGF, HGF, IL-6, IL-8, MMP-9, telomerase in peripheral blood of patients with head and neck squamous cell carcinoma. Clinical & Experimental Otorhinolaryngology, 2(4), 186–192.

    Article  Google Scholar 

  18. Zohn, I. E., Li, Y., Skolnik, E. Y., Anderson, K. V., Han, J., & Niswander, L. (2006). p38 and p38 interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell, 125, 957–969.

    Article  CAS  PubMed  Google Scholar 

  19. Cohen, J., et al. (2009). Attenuated transforming growth factor β signaling promotes nuclear factor-κB activation in head and neck cancer. Cancer Research, 69, 3415–3424.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Leemans, C. R., Braakhauis, B. J., & Brakenhoff, R. H. (2011). The molecular biology of head and neck cancer. Nature Reviews Cancer, 11, 9–22.

    Article  CAS  PubMed  Google Scholar 

  21. Olivier, M., Hollstein, M., & Hainaut, P. (2010). TP53 mutations in human cancers: origins, consequences, and clinical use. Cold Spring Harbor Perspectives in Biology, 2, a001008.

    Article  PubMed Central  PubMed  Google Scholar 

  22. Werness, B. A., Levine, A. J., & Howley, P. M. (1990). Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science, 248, 76–79.

    Article  CAS  PubMed  Google Scholar 

  23. Braakhuis, B. J., Leemans, C. R., & Brakenhoff, R. H. (2004). A genetic progression model of oral cancer: current evidence and clinical implications. Journal of Oral Pathology & Medicine, 33, 317–322.

    Article  CAS  Google Scholar 

  24. Pillai, M. R., & Nair, M. K. (2000). Development of a condemned mucosa syndrome and pathogenesis of human papillomavirus-associated upper aerodigestive tract and uterine cervical tumors. Experimental and Molecular Pathology, 69, 233–241.

    Article  CAS  PubMed  Google Scholar 

  25. Schache, A. G., Liloglou, T., Risk, J. M., Filia, A., Jones, T. M., Sheard, J., Woolgar, J. A., Helliwell, T. R., Triantafyllou, A., Robinson, M., Sloan, P., Harvey-Woodworth, C., Sisson, D., & Shaw, R. J. (2011). Evaluation of human papilloma virus diagnostic testing in oropharyngeal squamous cell carcinoma: sensitivity, specificity, and prognostic discrimination. Clinical Cancer Research, 17, 6262–6271.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Iancu, B. A., IV, Goia-Ruşanu, C. D., Stănescu, A., Huică, I., Nistor, E., Anton, G., & Pleşa, A. (2010). TGF-beta signalling pathway factors in HPV-induced cervical lesions. Roumanian Archives of Microbiology and Immunology, 69, 113–118.

    CAS  PubMed  Google Scholar 

  27. Lu, S. L., et al. (2006). Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes & Development, 20, 1331–1342.

    Article  CAS  Google Scholar 

  28. Trobridge, P., Knoblaugh, S., Washington, M. K., Munoz, N. M., Tsuchiya, K. D., & Rojas, A. (2009). TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway. Gastroenterology, 136, 1680–1688.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Prokopakis, P., Sourvinos, G., Koumantaki, Y., Koumantakis, E., & Spandidos, D. A. (2002). K-ras mutations and HPV infection in cervicitis and intraepithelial neoplasias of the cervix. Oncology Reports, 9, 129–133.

    CAS  PubMed  Google Scholar 

  30. Acuña Sanhueza, G. A., Faller, L., George, B., Koffler, J., Misetic, V., Flechtenmacher, C., Dyckhoff, G., Plinkert, P. P., Angel, P., Simon, C., & Hess, J. (2012). Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells. BMC Cancer, 12.

  31. Roepman, P., et al. (2005). An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas. Nature Genetics, 37, 182–186.

    Article  CAS  PubMed  Google Scholar 

  32. Zhang, R., & Song, C. (2014). Loss of CSMD1 or 2 may contribute to the poor prognosis of colorectal cancer patients. Tumour Biology, 35(5), 4419–4423.

    Article  CAS  PubMed  Google Scholar 

  33. Bernier, J. (2008). Drug insight: cetuximab in the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck. Nature Clinical Practice Oncology, 5, 705–713.

    Article  CAS  PubMed  Google Scholar 

  34. Wieduwilt, M. J., & Moasser, M. M. (2008). The epidermal growth factor receptor family: biology driving targeted therapeutics. Cellular and Molecular Life Sciences, 65, 1566–1584.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  35. Richard, V., & Pillai, M. R. (2010). The stem cell code in oral epithelial tumorigenesis: ‘the cancer stem cell shift hypothesis’. Biochimica et Biophysica Acta (BBA), 1806, 146–162.

    CAS  Google Scholar 

  36. Kumar, R., Wang, R. A., & Bagheri-Yarmand, R. (2003). Emerging roles of MTA family members in human cancers. Seminars in Oncology, 30, 30–37.

    Article  CAS  PubMed  Google Scholar 

  37. Li, D. Q., Pakala, S. B., Nair, S. S., Eswaran, J., & Kumar, R. (2012). Metastasis-associated protein 1/nucleosome remodeling and histone deacetylase complex in cancer. Cancer Research, 72, 387–394.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  38. Li, S. H., Tian, H., Yue, W. M., Li, L., Gao, C., Li, W. J., Hu, W. S., & Hao, B. (2012). Metastasis-associated protein 1 nuclear expression is closely associated with tumor progression and angiogenesis in patients with esophageal squamous cell cancer. World Journal of Surgery, 36, 623–631.

    Article  CAS  PubMed  Google Scholar 

  39. Schultz, J. D., Sommer, J. U., Hoedt, S., Erben, P., Hofheinz, R. D., Faber, A., Thorn, C., Hörmann, K., & Sauter, A. (2011). Chemotherapeutic alteration of β-catenin and c-kit expression by imatinib in p16-positive squamous cell carcinoma compared to HPV-negative HNSCC cells in vitro. Oncology Reports, 27, 270–280.

    PubMed  Google Scholar 

  40. Stewart, S., Dawson, C. W., Takada, K., Curnow, J., Moody, C. A., Sixbey, J. W., & Young, L. S. (2004). Epstein–Barr virus-encoded LMP2A regulates viral and cellular gene expression by modulation of the NF-κB transcription factor pathway. Proceedings of the National Academy of Sciences, 101, 15730–15735.

    Article  CAS  Google Scholar 

  41. Hsieh, A. C., Liu, Y., Edlind, M. P., Ingolia, N. T., Janes, M. R., Sher, A., Shi, E. Y., Stumpf, C. R., Christensen, C., Bonham, M. J., Wang, S., Ren, P., Martin, M., Jessen, K., Feldman, M. E., Weissman, J. S., Shokat, K. M., Rommel, C., & Ruggero, D. (2012). The translational landscape of mTOR signalling steers cancer initiation and metastasis. Nature, 485, 55–61.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  42. Lin, Z., Wan, X., Jiang, R., Deng, L., et al. (2014). EBV-encoded LMP2A promotes EMT in nasopharyngeal carcinoma via MTA1 and mTOR signaling induction. Journal of Virology, 88(20):11872–85.

  43. Cho, C. Y., Wang, J. H., Chang, H. C., et al. (2007). Epigenetic inactivation of the metastasis suppressor RECK enhances invasion of human colon cancer cells. Journal of Cellular Physiology, 213, 65–69.

    Article  CAS  PubMed  Google Scholar 

  44. Prasad, N. B., Fischer, A. C., Chuang, A. Y., Wright, J. M., Yang, T., Tsai, H. L., Westra, W. H., Liegeois, N. J., Hess, A. D., & Tufaro, A. P. (2014). Differential expression of degradome components in cutaneous squamous cell carcinomas. Modern Pathology, 27, 945–957.

    Article  CAS  PubMed  Google Scholar 

  45. Sasahara, R. M., Brochado, S. M., Takahashi, C., Oh, J., Maria-Engler, S. S., Granjeiro, J. M., Noda, M., & Sogayar, M. C. (2002). Transcriptional control of the RECK metastasis/angiogenesis suppressor gene. Cancer Detection and Prevention, 26, 435–443.

    Article  CAS  PubMed  Google Scholar 

  46. Deng, Y., Zhou, D., & Zeng, L. (2011). Expression and significance of MTA1 and RECK gene in nasopharyngeal carcinoma. Lin Chung Er Bi Yan HouTou Jing WaiKeZaZhi, 25, 534–538.

    CAS  Google Scholar 

  47. Song, Q., Zhang, H., Wang, M., & Song, W. (2013). MTA1 promotes nasopharyngeal carcinoma growth in vitro and in vivo. Journal of Experimental & Clinical Cancer Research, 31, 54.

    Article  Google Scholar 

  48. Rathinam, R., Berrier, A., & Alahari, S. K. (2011). Role of Rho GTPases and their regulators in cancer progression. Frontiers in Bioscience, 17, 2561–2571.

    Article  Google Scholar 

  49. Bailey, J. M., Mohr, A. M., & Hollingsworth, M. A. (2009). Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer. Oncogene, 28, 3513–3525.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  50. Song, Q., Li, Y., Zheng, X., Fang, Y., Chao, Y., Yao, K., & Zhu, X. (2013). MTA1 contributes to actin cytoskeleton reorganization and metastasis of nasopharyngeal carcinoma by modulating Rho GTPases and Hedgehog signaling. The International Journal of Biochemistry & Cell Biology, 45, 1439–1446.

    Article  CAS  Google Scholar 

  51. Roepman, P., de Jager, A., Marian, J. A., Koerkamp, G., et al. (2006). Maintenance of head and neck tumor gene expression profiles upon lymph node metastasis. Cancer Research, 66, 11110.

    Article  CAS  PubMed  Google Scholar 

  52. Kawasaki, G., Yanamoto, S., Yoshitomi, I., Yamada, S., & Mizuno, A. (2008). Overexpression of metastasis-associated MTA1 in oral squamous cell carcinomas: correlation with metastasis and invasion. International Journal of Oral and Maxillofacial Surgery, 37, 1039–1046.

    Article  CAS  PubMed  Google Scholar 

  53. Wang, H., Huang, G., Wei, F., Mo, L., & Kuang, G. (2006). Correlation between expression of the MTA1 gene and carcinomas of larynx. Lin Chuang Er Bi Yan HouKeZaZhi. (Chinese), 20, 113–115.

    Google Scholar 

  54. Tang, Q. F., Ji, W. Y., Pan, Z. M., Zheng, Y., & Guan, C. (2003). Expression of the metastasis-associated gene 1 in laryngeal squamous cell carcinoma: correlation with cervical lymph node metastasis. ZhonghuaEr Bi Yan HouKeZaZhi. (Chinese), 38, 213–216.

    Google Scholar 

  55. Forastiere, A., Koch, W., Trotti, A., & Sidransky, D. (2001). Head and neck cancer. New England Journal of Medicine, 345,1890–1900.

  56. Park, J. O., Jung, C. K., Sun, D. I., Joo, Y. H., & Kim, M. S. (2011). Relationships between metastasis-associated protein (MTA) 1 and lymphatic metastasis in tonsil cancer. European Archives of Otorhinolaryngology, 268, 1329–1334.

    Article  PubMed  Google Scholar 

  57. Liu, T., Yang, M., Yang, S., Ge, T., Gu, L., & Lou, G. (2013). Metastasis-associated protein 1 is a novel marker predicting survival and lymph nodes metastasis in cervical cancer. Human Pathology, 44, 2275–2281.

    Article  CAS  PubMed  Google Scholar 

  58. Li, W.-F., Liu, N., Cui, R.-X., He, Q.-M., Chen, M., Jiang, N., Sun, Y., Zeng, J., Liu, L.-Z., & Ma, J. (2012). Nuclear overexpression of metastasis-associated protein 1 correlates significantly with poor survival in nasopharyngeal carcinoma. Journal of Translational Medicine, 10, 78.

    Article  PubMed Central  PubMed  Google Scholar 

  59. Liu, J., Xu, D., Wang, H., Zhang, Y., & Chang, Y. (2014). The subcellular distribution and function of MTA1 in cancer differentiation. Oncotarget, 5, 5153–5164.

    PubMed Central  PubMed  Google Scholar 

  60. Yu, C. H., Chen, H. H., Wang, J. T., et al. (2007). Nuclear expression of metastasis-associated protein 1 (MTA1) is inversely related to progression of oral squamous cell carcinoma in Taiwan. Journal of Dental Sciences, 2.

  61. Luo, J., Su, F., Chen, D., et al. (2000). Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature, 408, 377–381.

    Article  CAS  PubMed  Google Scholar 

  62. Yang, W., Cai, Q., Lui, V.W., Everley, P.A., Kim, J., Bhola, N., Quesnelle, K.M., Zetter, B.R., Steen, H., Freeman, M.R., & Grandis, J.R. (2010). Quantitative proteomics analysis reveals molecular networks regulated by epidermal growth factor receptor level in head and neck cancer. J Proteome Res, 9, 3073-3082

  63. Ambatipudi, S., Gerstung, M., Pandey, M., Samant, T., et al. (2012). Genome-wide expression and copy number analysis identifies driver genes in gingivobuccal cancers. Genes, Chromosomes & Cancer, 51, 161–173.

    Article  CAS  Google Scholar 

  64. Peng, C.-H., Liao, C. T., Peng, S.-C., Chen, Y.-J., Cheng, A.-J., Juang, J.-L., Tsai, C.-Y., Chen, T.-C., Chuang, Y.-J., Tang, C.-Y., Hsieh, W.-P., & Yen, T.-C. (2011). A novel molecular signature identified by systems genetics approach predicts prognosis in oral squamous cell carcinoma. PLoS One, 6.

  65. Estilo, C. L., O-charoenrat, P., Talbot, S., Socci, N. D., et al. (2009). Oral tongue cancer gene expression profiling: identification of novel potential prognosticators by oligonucleotide microarray analysis. BMC Cancer, 9.

  66. Frierson, H. F., Jr., El-Naggar, A. K., Welsh, J. B., Sapinoso, L. M., Su, A. I., Cheng, J., Saku, T., Moskaluk, C. A., & Hampton, G. M. (2002). Large scale molecular analysis identifies genes with altered expression in salivary adenoid cystic carcinoma. American Journal of Pathology, 161, 1315–1323.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  67. Bagheri-Yarmand, R., Talukder, A. H., Wang, R. A., Vadlamudi, R. K., & Kumar, R. (2004). Metastasis-associated protein 1 deregulation causes inappropriate mammary gland development and tumorigenesis. Development, 131, 3469–3479.

    Article  CAS  PubMed  Google Scholar 

  68. Pakala, S. B., Singh, K., Reddy, S. D., Ohshiro, K., Li, D. Q., Mishra, L., et al. (2011). TGF-b1 signaling targets metastasis-associated protein 1, a new effector in epithelial cells. Oncogene, 30, 2230–2241.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  69. Dannenmann, C., Shabani, N., Friese, K., Jeschke, U., Mylonas, I., & Brüning, A. (2008). The metastasis-associated gene MTA1 is upregulated in advanced ovarian cancer, represses ERbeta, and enhances expression of oncogenic cytokine GRO. Cancer Biology and Therapy, 7, 1460–1467.

    Article  CAS  PubMed  Google Scholar 

  70. Kumar, R., Balasenthil, S., Manavathi, B., Rayala, S. K., & Pakala, S. B. (2010). Metastasis-associated protein 1 and its short form variant stimulates Wnt1 transcription through promoting its derepression from Six3 corepressor. Cancer Research, 70, 6649–6658.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

Hezlin Marzook is supported by a Senior Research Fellowship from the Council of Scientific and Industrial Research. Deivendran S. is supported by a Senior Research Fellowship from the Indian Council of Medical Research (ICMR).

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  1. Cancer Research Program 9, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India

    Hezlin Marzook, S. Deivendran, Rakesh Kumar & M. Radhakrishna Pillai

  2. Department of Biochemistry and Molecular Medicine, George Washington University, Washington, DC, 20037, USA

    Rakesh Kumar

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  1. Hezlin Marzook
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  2. S. Deivendran
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Hezlin Marzook and S. Deivendran have equal contribution.

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Marzook, H., Deivendran, S., Kumar, R. et al. Role of MTA1 in head and neck cancers. Cancer Metastasis Rev 33, 953–964 (2014). https://doi.org/10.1007/s10555-014-9521-5

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