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15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?

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Abstract

15-Lipoxygenase-1 (15-LOX-1) is an inducible and highly regulated enzyme in normal human cells that plays a key role in the production of lipid signaling mediators, such as 13-hydroxyoctadecadienoic acid (13-HODE) from linoleic acid. 15-LOX-1 significantly contributes to the resolution of inflammation and to the terminal differentiation of normal cells. 15-LOX-1 is downregulated in human colorectal polyps and cancers. Emerging data support a tumor suppressor role for 15-LOX-1, especially in colon cancer. These data indicate that 15-LOX-1 promotes various anti-tumorigenic events, including cell differentiation and apoptosis, and inhibits chronic inflammation, angiogenesis, and metastasis. The transcriptional repression of 15-LOX-1 in colon cancer cells is complex and involves multiple mechanisms (e.g., histone methylation, transcriptional repressor binding). Re-expression of 15-LOX-1 in colon cancer cells can function as an important therapeutic mechanism and could be further exploited to develop novel treatment approaches for this common cancer.

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Acknowledgments

This work was supported in part by National Cancer Institute R01 grants 137213 and 142969, by the Duncan Family Institute Seed Funding Research Program, and by the National Institutes of Health through MD Anderson’s Cancer Center Support Grant, CA016672.

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Authors and Affiliations

  1. Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Sun IL Lee & Imad Shureiqi

  2. Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030-4009, USA

    Xiangsheng Zuo & Imad Shureiqi

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  1. Sun IL Lee
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Correspondence to Imad Shureiqi.

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IL Lee, S., Zuo, X. & Shureiqi, I. 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?. Cancer Metastasis Rev 30, 481–491 (2011). https://doi.org/10.1007/s10555-011-9321-0

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