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The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass

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Abstract

To evaluate the relationships between parameters of the pulsatile flow form in the optic nerve head shown by laser speckle flowgraphy (LSFG) and the left ventricular (LV) end-diastolic pressure and mass obtained by echocardiography. We cross sectional analyzed the cases of 175 subjects who had undergone polysomnography. Standard M-mode two-dimensional color Doppler imaging was performed to evaluate the E/e′ ratio (which represents the LV end-diastolic pressure) and LV mass. The pulsatile flow form analysis parameters of the blowout score and acceleration time index were evaluated. The parameters were analyzed separately for the tissue, vessels and throughout the optic nerve head (All). We performed a single regression analysis and a multiple regression analysis to determine whether pulsatile flow form are independent factors for the E/e′ ratio and LV mass. The factors contributing independently to the E/e′ ratio were blowout time-Tissue (standard regression = − 0.27, t-value = − 2.90, p < 0.0001) and body mass index (BMI) (0.16, 2.05, p = 0.04). The factors that were shown to independently contribute to the LV mass were urinary albumin concentration (0.30, − 2.90, p < 0.0001), BMI (0.28, 4.09, p < 0.0001), differences of gender (men = 1, women = 0: 0.23, 3.28, p = 0.001), acceleration time index-Vessel (− 0.23, − 2.99, p = 0.003) and mean arterial blood pressure (0.17, 2.61, p = 0.01). Our results confirmed that parameters of the pulsatile flow form of ocular microcirculation obtained by LSFG are significantly correlated with the LV end-diastolic pressure ratio and LV mass.

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Funding

This study had no sponsorship or other support.

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Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Toho University, 6-11-1, Omori-Nishi, Ota-ku, Tokyo, 143-8541, Japan

    Tomoaki Shiba, Tadashi Matsumoto & Yuichi Hori

  2. Cardiovascular Center, Toho University Sakura Medical Center, 564-1 Shimoshizu, Sakura, Chiba, 285-8741, Japan

    Mao Takahashi

  3. Shiba Eye Clinic, Shikawatashi, Yotsukaido, 284-0003, Chiba, Japan

    Chieko Shiba

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  1. Tomoaki Shiba
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Correspondence to Tomoaki Shiba.

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Ethical approval

The Institutional Review Board of Toho University Sakura Medical Center approved the study (No 2011-009 and 2010-012).

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We started research after obtaining informed consent from all participants in accord with the Declaration of Helsinki.

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Shiba, T., Takahashi, M., Shiba, C. et al. The relationships between the pulsatile flow form of ocular microcirculation by laser speckle flowgraphy and the left ventricular end-diastolic pressure and mass. Int J Cardiovasc Imaging 34, 1715–1723 (2018). https://doi.org/10.1007/s10554-018-1388-z

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  • DOI: https://doi.org/10.1007/s10554-018-1388-z

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