In-vitro and in-silico studies have shown that stent design and struts thickness introduce significant changes in local hemodynamics. The protruding struts disrupt the laminar flow with the impacts of strut thickness and strut shape. Angiographic and optical coherence tomography (OCT) data were implemented to reconstruct three-dimensional (3D) geometry of the right coronary artery (RCA) of a healthy mini-swine implanted with 3.0 × 14 mm ArterioSorb (Arterius, UK) with 95 micron (µm) strut thickness in proximal segment (final post-dilatation mean lumen diameter: 2.78 mm) and 3.0 × 14 mm ArterioSorb with 120 µm strut thickness in mid-segment (final post-dilatation mean lumen diameter: 2.80 mm) of the vessel.
During computational fluid dynamic (CFD) study, endothelial shear stress (ESS) was quantified in the scaffolded segment around the circumference of the lumen per 5°-subunit and along the axial direction per 200 µm interval [1]. Median ESS was lower in the distal scaffold (ArterioSorb-120 µm) [1.17 (0.78–1.55) Pa] than in the proximal scaffold (ArterioSorb-95 µm) [1.25 (0.92–1.88) Pa] in Newtonian steady flow simulation (p < 0.0001). 37.4% of the scaffolded surface in ArterioSorb-120 µm and 32.6% in ArterioSorb-95 µm was exposed to a low (<1 Pa) athero-promoting ESS (Fig. 1). The p-value is based on 5°-subunit (n = 15,984) analysis using mixed effects regression model.
The difference in ESS may stem from strut thickness, luminal diameter, vessel curvature and flow boundary conditions. In the present case, after excluding other factors, lower ESS in ArterioSorb-120 µm is presumably ascribed to the thicker struts (Fig. 1). However, even in ArterioSorb-120 µm, the shear stress was not as low as reported in Absorb BVS (Median ESS:0.57 Pa) [2] which should be attributed to the thinner struts of ArterioSorb.