Skip to main content
SpringerLink
Log in

Cardiovascular magnetic resonance tagging imaging correlates with myocardial dysfunction and T2 mapping in idiopathic dilated cardiomyopathy

  • Original Paper
  • Published:
The International Journal of Cardiovascular Imaging Aims and scope Submit manuscript

Abstract

To evaluate the details of myocardial dysfunction in dilated cardiomyopathy (DCM) patients using tagging images and the correlation of tagging imaging with tissue characteristics. Circumferential strain (Ecc) derived from tagging images was measured in 15 normal (NML) subjects (15 males; mean age 28.5 years) and 12 DCM patients (7 males; mean age 48.9 years). The following parameters were compared: (1) the magnitude of peak Ecc (Ecc*); (2) the coefficient of variation of the time of Ecc* (CVtime*), which indexes dyssynchrony; and (3) descriptive findings of time-Ecc curves. We also evaluated the correlations of Ecc* in DCM patients with ejection fraction (EF), myocardial T2 values, and late gadolinium enhancement (LGE). Mean Ecc*s in DCM patients and NML subjects were −12.7 and −23.5 %, respectively (P < 0.0001). Mean CVtime*s were 15.2 and 4.5 %, respectively (P = 0.0002). The findings of pre-systolic extension and systolic stretch in the septum were observed in 6 (50 %) and 10 (83.3 %) DCM patients and in none of the NML participants. Ecc* was correlated with EF (P < 0.0001, R 2 = 0.90) and T2 values (P = 0.018, R 2 = 0.44) but not with LGE (P = 0.072, R 2 = 0.28). Tagging images revealed the reduction of myocardial function as well as dyssynchrony in DCM patients. Myocardial dysfunction occurred coincidently with myocardial inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Moore CC, McVeigh ER, Zerhouni EA (2000) Quantitative tagged magnetic resonance imaging of the normal human left ventricle. Top Magn Reson Imaging 11(6):359–371

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EP (1988) Human heart: tagging with MR imaging—a method for noninvasive assessment of myocardial motion. Radiology 169(1):59–63

    Article  CAS  PubMed  Google Scholar 

  3. Croisille P, Moore CC, Judd RM, Lima JA, Arai M, McVeigh ER, Becker LC, Zerhouni EA (1999) Differentiation of viable and nonviable myocardium by the use of three-dimensional tagged MRI in 2-day-old reperfused canine infarcts. Circulation 99(2):284–291

    Article  CAS  PubMed  Google Scholar 

  4. Gotte MJ, van Rossum AC, Twisk JWR, Kuijer JPA, Marcus JT, Visser CA (2001) Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium. J Am Coll Cardiol 37(3):808–817

    Article  CAS  PubMed  Google Scholar 

  5. Kuijpers D, Ho KY, van Dijkman PR, Vliegenthart R, Oudkerk M (2003) Dobutamine cardiovascular magnetic resonance for the detection of myocardial ischemia with the use of myocardial tagging. Circulation 107(12):1592–1597

    Article  PubMed  Google Scholar 

  6. Luk A, Ahn E, Soor GS, Butany J (2009) Dilated cardiomyopathy: a review. J Clin Pathol 62(3):219–225

    Article  CAS  PubMed  Google Scholar 

  7. Jefferies JL, Towbin JA (2010) Dilated cardiomyopathy. Lancet 375(9716):752–762

    Article  PubMed  Google Scholar 

  8. Jeserich M, Foll D, Olschewski M, Kimmel S, Friedrich MG, Bode C, Geibel A (2012) Evidence of myocardial edema in patients with nonischemic dilated cardiomyopathy. Clin Cardiol 35(6):371–376

    Article  PubMed  Google Scholar 

  9. Assomull RG, Prasad SK, Lyne J, Smith G, Burman ED, Khan M, Sheppard MN, Poole-Wilson PA, Pennell DJ (2006) Cardiovascular magnetic resonance, fibrosis, and prognosis in dilated cardiomyopathy. J Am Coll Cardiol 48(10):1977–1985

    Article  PubMed  Google Scholar 

  10. McCrohon JA, Moon JC, Prasad SK, McKenna WJ, Lorenz CH, Coats AJ, Pennell DJ (2003) Differentiation of heart failure related to dilated cardiomyopathy and coronary artery disease using gadolinium-enhanced cardiovascular magnetic resonance. Circulation 108(1):54–59

    Article  CAS  PubMed  Google Scholar 

  11. MacGowan GA, Shapiro EP, Azhari H, Siu CO, Hees PS, Hutchins GM, Weiss JL, Rademakers FE (1997) Noninvasive measurement of shortening in the fiber and cross-fiber directions in the normal human left ventricle and in idiopathic dilated cardiomyopathy. Circulation 96(2):535–541

    Article  CAS  PubMed  Google Scholar 

  12. Nelson GS, Curry CW, Wyman BT, Kramer A, Declerck J, Talbot M, Douglas MR, Berger RD, McVeigh ER, Kass DA (2000) Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation 101(23):2703–2709

    Article  CAS  PubMed  Google Scholar 

  13. Young AA, Dokos S, Powell KA, Sturm B, McCulloch AD, Starling RC, McCarthy PM, White RD (2001) Regional heterogeneity of function in nonischemic dilated cardiomyopathy. Cardiovasc Res 49(2):308–318

    Article  CAS  PubMed  Google Scholar 

  14. Han Y, Chan J, Haber I, Peters DC, Zimetbaum PJ, Manning WJ, Yeon SB (2010) Circumferential myocardial strain in cardiomyopathy with and without left bundle branch block. J Cardiovasc Magn Reson 12:2

    Article  PubMed Central  PubMed  Google Scholar 

  15. Kanzaki H, Nakatani S, Yamada N, Urayama S, Miyatake K, Kitakaze M (2006) Impaired systolic torsion in dilated cardiomyopathy: reversal of apical rotation at mid-systole characterized with magnetic resonance tagging method. Basic Res Cardiol 101(6):465–470

    Article  PubMed  Google Scholar 

  16. Russel IK, Gotte MJ, de Roest GJ, Marcus JT, Tecelao SR, Allaart CP, de Cock CC, Heethaar RM, van Rossum AC (2009) Loss of opposite left ventricular basal and apical rotation predicts acute response to cardiac resynchronization therapy and is associated with long-term reversed remodeling. J Card Fail 15(8):717–725

    Article  PubMed  Google Scholar 

  17. Elliott P, Andersson B, Arbustini E, Bilinska Z, Cecchi F, Charron P, Dubourg O, Kuhl U, Maisch B, McKenna WJ, Monserrat L, Pankuweit S, Rapezzi C, Seferovic P, Tavazzi L, Keren A (2008) Classification of the cardiomyopathies: a position statement from the European Society Of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur Heart J 29(2):270–276

    Article  PubMed  Google Scholar 

  18. Arts T, Prinzen FW, Delhaas T, Milles JR, Rossi AC, Clarysse P (2010) Mapping displacement and deformation of the heart with local sine-wave modeling. IEEE Trans Med Imaging 29(5):1114–1123

    Article  CAS  PubMed  Google Scholar 

  19. Axel L, Dougherty L (1989) Heart wall motion: improved method of spatial modulation of magnetization for MR imaging. Radiology 172(2):349–350

    Article  CAS  PubMed  Google Scholar 

  20. Axel L, Dougherty L (1989) MR imaging of motion with spatial modulation of magnetization. Radiology 171(3):841–845

    Article  CAS  PubMed  Google Scholar 

  21. Shehata ML, Cheng S, Osman NF, Bluemke DA, Lima JA (2009) Myocardial tissue tagging with cardiovascular magnetic resonance. J Cardiovasc Magn Reson 11:55

    Article  PubMed Central  PubMed  Google Scholar 

  22. Kuijer JP, Marcus JT, Gotte MJ, van Rossum AC, Heethaar RM (2002) Three-dimensional myocardial strains at end-systole and during diastole in the left ventricle of normal humans. J Cardiovasc Magn Reson 4(3):341–351

    Article  PubMed  Google Scholar 

  23. Del-Canto I, Lopez-Lereu MP, Monmeneu JV, Croisille P, Clarysse P, Chorro FJ, Bodi V, Moratal D (2013) Characterization of normal regional myocardial function by MRI cardiac tagging. J Magn Reson Imaging. doi:10.1002/jmri.24539 (Epub ahead of print)

  24. Meinertz T, Hofmann T, Kasper W, Treese N, Bechtold H, Stienen U, Pop T, Leitner ER, Andresen D, Meyer J (1984) Significance of ventricular arrhythmias in idiopathic dilated cardiomyopathy. Am J Cardiol 53(7):902–907

    Article  CAS  PubMed  Google Scholar 

  25. Akar FG, Tomaselli GF (2005) Conduction abnormalities in nonischemic dilated cardiomyopathy: basic mechanisms and arrhythmic consequences. Trends Cardiovasc Med 15(7):259–264

    Article  CAS  PubMed  Google Scholar 

  26. Jeung MY, Germain P, Croisille P, El ghannudi S, Roy C, Gangi A (2012) Myocardial tagging with MR imaging: overview of normal and pathologic findings. Radiographics 32(5):1381–1398

    Article  PubMed  Google Scholar 

  27. Zwanenburg JJ, Gotte MJ, Marcus JT, Kuijer JP, Knaapen P, Heethaar RM, van Rossum AC (2005) Propagation of onset and peak time of myocardial shortening in time of myocardial shortening in ischemic versus nonischemic cardiomyopathy: assessment by magnetic resonance imaging myocardial tagging. J Am Coll Cardiol 46(12):2215–2222

    Article  PubMed  Google Scholar 

  28. Kim RJ, Chen EL, Lima JA, Judd RM (1996) Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after acute reperfused infarction. Circulation 94(12):3318–3326

    Article  CAS  PubMed  Google Scholar 

  29. Kim RJ, Wu E, Rafael A, Chen EL, Parker MA, Simonetti O, Klocke FJ, Bonow RO, Judd RM (2000) The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction. N Engl J Med 343(20):1445–1453

    Article  CAS  PubMed  Google Scholar 

  30. Lehrke S, Lossnitzer D, Schob M, Steen H, Merten C, Kemmling H, Pribe R, Ehlermann P, Zugck C, Korosoglou G, Giannitsis E, Katus HA (2011) Use of cardiovascular magnetic resonance for risk stratification in chronic heart failure: prognostic value of late gadolinium enhancement in patients with non-ischaemic dilated cardiomyopathy. Heart 97(9):727–732

    Article  PubMed  Google Scholar 

  31. Maehashi N, Yokota Y, Takarada A, Usuki S, Maeda S, Yoshida H, Sugiyama T, Fukuzaki H (1991) The role of myocarditis and myocardial fibrosis in dilated cardiomyopathy. Analysis of 28 necropsy cases. Jpn Heart J 32(1):1–15

    Article  CAS  PubMed  Google Scholar 

  32. Giri S, Chung YC, Merchant A, Mihai G, Rajagopalan S, Raman SV, Simonetti OP (2009) T2 quantification for improved detection of myocardial edema. J Cardiovasc Magn Reson 11:56

    Article  PubMed Central  PubMed  Google Scholar 

  33. Verhaert D, Thavendiranathan P, Giri S, Mihai G, Rajagopalan S, Simonetti OP, Raman SV (2011) Direct T2 quantification of myocardial edema in acute ischemic injury. JACC Cardiovasc Imaging 4(3):269–278

    Article  PubMed  Google Scholar 

  34. von Knobelsdorff-Brenkenhoff F, Prothmann M, Dieringer MA, Wassmuth R, Greiser A, Schwenke C, Niendorf T, Schulz-Menger J (2013) Myocardial T1 and T2 mapping at 3 T: reference values, influencing factors and implications. J Cardiovasc Magn Reson 15(1):53

    Article  Google Scholar 

Download references

Acknowledgments

The author (AKK) received an award from the Japanese Society for Magnetic Resonance in Medicine and Bayer Schering Pharma. This study was partially funded by this award. I would like to express my gratitude to my family for the support of my fellowship and to Professor Gabriel P. Krestin at Erasmus Medical Center for his insightful comments and suggestions.

Conflict of interest

None.

Author information

Authors and Affiliations

  1. Department of Radiology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Atsushi K. Kono

  2. Department of Radiology, Erasmus Medical Center, ‘s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands

    Atsushi K. Kono

  3. Department of Radiology, Université Jean Monnet Saint-Etienne, CREATIS, UMR CNRS 5220-INSERM U1044, Lyon, France

    Pierre Croisille

  4. Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Atsushi K. Kono, Tatsuya Nishii & Kazuro Sugimura

  5. Division of Radiology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan

    Koya Nishiyama & Katsusuke Kyotani

  6. Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Hyogo, Japan

    Mayumi Shigeru, Sachiko Takamine & Sei Fujiwara

Authors
  1. Atsushi K. Kono
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierre Croisille
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tatsuya Nishii
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Koya Nishiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Katsusuke Kyotani
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mayumi Shigeru
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Sachiko Takamine
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sei Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Kazuro Sugimura
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Atsushi K. Kono.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kono, A.K., Croisille, P., Nishii, T. et al. Cardiovascular magnetic resonance tagging imaging correlates with myocardial dysfunction and T2 mapping in idiopathic dilated cardiomyopathy. Int J Cardiovasc Imaging 30 (Suppl 2), 145–152 (2014). https://doi.org/10.1007/s10554-014-0523-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10554-014-0523-8

Keywords

Search

Navigation