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Coronary artery angiography and myocardial viability imaging: a 3.0-T contrast-enhanced magnetic resonance coronary artery angiography with Gd-BOPTA

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Abstract

With improving MR sequence, phase-array coil and image quality, cardiac magnetic resonance imaging is becoming a promising method for a comprehensive non-invasive evaluation of coronary artery and myocardial viability. The study aimed to evaluate contrast-enhanced whole-heart coronary MR angiography (CE WH-CMRA) at 3.0-Tesla for the diagnosis of significant stenosis (≥50 %) and detection of myocardial infarction (MI) in patients with suspected coronary artery disease (CAD). CE WH-CMRA was performed in consecutive 70 patients with suspected CAD by using a 3.0-T MR system. A respiratory-gated, electrocardiography-triggered, inversion-recovery, segmented fast low angle shot sequence (TI = 200 ms) was used. Data acquisition began 60 s after the slow injection of Gd-BOPTA (0.2 mmol/kg body weight, at an injection rate 0.3 ml/s). At last, breath-hold 2D-PSIR-SSFP sequence was performed. Diagnostic accuracy of CE WH-CMRA in detecting significant stenosis (≥50 %) was evaluated using invasive coronary angiography as the referenced standard. The MI region appearing as high signal intensity visualized on CEWH-CMRA and 2D-PSIR-SSFP images were compared and analyzed. CE WH-CMRA correctly identified 42 of 44 patients with significant CAD. The overall sensitivity, specificity, negative predictive value, positive predictive value and accuracy for diagnosing significant CAD was 83.6, 95.8, 96.0, 82.8 and 93.4 % respectively. The MI region detected by WH-CMRA and 2D-PSIR-SSFP were consistent in 10 patients and these segments manifested with transmural or subendocardial enhancement patterns. Only one MI patient was judged inconsistent between WH-CMRA and 2D-PSIR-SSFP, who was confirmed by clinical and electrocardiogram results. The enhancement pattern in this patient was spotted and focal in 2D-PSIR-SSFP, but was dismissed by WH-CMRA. It is feasible to obtain information about coronary artery stenosis and myocardial viability in a single CE WH-CMRA with administration of Gd-BOPTA.

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Abbreviations

CE WH-CMRA:

Contrast-enhanced whole heart cardiac magnetic angiography

CAD:

Coronary artery disease

FLASH:

Fast low angle shot

PSIR:

Phase-sensitive inversion recovery

SSFP:

Steady-state free procession

DE:

Delayed enhancement

MI:

Myocardial infarction

ECG:

Electrocardiogram

HASTE:

Half-Fourier single shot turbo spin echo

GRAPPA:

Generalized autocalibrating partially parallel acquisition

ICA:

Invasive coronary angiography

MIP:

Maximum intensity projection

MPR:

Multiplanar reformation

QCA:

Quantitative coronary angiography

LAD:

Left anterior descending artery

LCx:

Left circumflex artery

RCA:

Right coronary artery

PL:

Posterolateral branch

PDA:

Posterior descending artery

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Acknowledgments

This study was supported by a grant from the National Natural Science Foundation of China (No. 81201070) and Fudan University Foundation for young teachers for the improvement of scientific research ability (Contract Grant Number: 20520133486).

Conflict of interest

None.

Ethical standard

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Medical Imaging Institute, 180#, Feng Lin Road, Shanghai, 200032, China

    Hong Yun, Hang Jin, Shan Yang & Meng-su Zeng

  2. Department of Cardiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Cardiovascular Diseases, 180#, Feng Lin Road, Shanghai, 200032, China

    Dong Huang & Zhang-wei Chen

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  1. Hong Yun
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  2. Hang Jin
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  3. Shan Yang
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Correspondence to Meng-su Zeng.

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Yun, H., Jin, H., Yang, S. et al. Coronary artery angiography and myocardial viability imaging: a 3.0-T contrast-enhanced magnetic resonance coronary artery angiography with Gd-BOPTA. Int J Cardiovasc Imaging 30, 99–108 (2014). https://doi.org/10.1007/s10554-013-0297-4

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  • DOI: https://doi.org/10.1007/s10554-013-0297-4

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