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The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: the 2009–2010 National Health and Nutrition Examination Survey

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Abstract

Purpose

We evaluated the association between clinically assessed periodontal disease and serum prostate-specific antigen (PSA) concentration in men without a prostate cancer diagnosis in a US nationally representative sample of non-institutionalized men.

Methods

Included were 1263 men aged ≥ 40 years who participated in the National Health and Nutrition Examination Survey in 2009–2010. Measurements of periodontal health and tooth count were used to define periodontal disease severity (no, mild, moderate, severe) and edentulism. Linear and logistic regressions were used to estimate the association of periodontal disease severity and edentulism with PSA concentration and elevated PSA, respectively.

Results

Adjusting for age and other factors including race, body mass index, and education, the natural logarithm of PSA concentration did not change with increasing severity (mild − 0.20, 95% confidence interval [CI] − 0.34 to − 0.05; moderate − 0.12, 95% CI − 0.26 to 0.01; severe − 0.16, 95% CI − 0.43 to 0.12; edentulism − 0.16, 95% CI − 0.35 to 0.04; P-trend 0.13) compared with dentate men without periodontal disease. Although the multivariable-adjusted ORs of elevated PSA were not statistically significant, participants with more severe periodontal disease were less likely to have PSA > 2.0 and > 2.5 ng/mL, but more likely to have PSA > 4.0 ng/mL, compared to dentate men without periodontal disease. Similar non-significant associations with PSA were observed when comparing edentulous men to dentate men without periodontal disease.

Conclusions

In this US nationally representative sample, men with periodontal disease did not have higher serum PSA and were not more likely to have clinically elevated PSA after taking into account age and other factors, contrary to the hypothesis. This study suggests that periodontal disease does not notably affect the specificity of PSA for prostate cancer screening.

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Funding

This work was supported in part by the National Cancer Institute (P30 CA006973, Nelson) and the Maryland Cigarette Restitution Fund at Johns Hopkins.

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Authors and Affiliations

  1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Room E6132, 615 N Wolfe St, Baltimore, MD, 21205, USA

    Yuhan Huang, Jiayun Lu & Elizabeth A. Platz

  2. Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, USA

    Dominique S. Michaud

  3. Department of Urology and the James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    H. Ballentine Carter & Elizabeth A. Platz

  4. Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA

    H. Ballentine Carter & Elizabeth A. Platz

Authors
  1. Yuhan Huang
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  2. Dominique S. Michaud
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  3. Jiayun Lu
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  4. H. Ballentine Carter
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  5. Elizabeth A. Platz
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Correspondence to Elizabeth A. Platz.

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Huang, Y., Michaud, D.S., Lu, J. et al. The association between clinically determined periodontal disease and prostate-specific antigen concentration in men without prostate cancer: the 2009–2010 National Health and Nutrition Examination Survey. Cancer Causes Control 30, 1293–1300 (2019). https://doi.org/10.1007/s10552-019-01238-3

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  • DOI: https://doi.org/10.1007/s10552-019-01238-3

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