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Childhood lymphoma incidence patterns by ICCC-3 subtype in Mexico City metropolitan area population insured by Instituto Mexicano del Seguro Social, 1996–2010

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Abstract

Purpose

We reviewed the childhood lymphomas epidemiological data for the Mexico City metropolitan area (MCMA).

Methods

Data analysis from children (0–14 years old) diagnosed with lymphoma during the period 1996–2010 was performed at the Mexican Childhood Cancer Registry. Histological subtype was determined according to the International Classification of Childhood Cancer 3 (ICCC-3). Age-adjusted incidence rates were calculated per 1,000,000 children/year by age, gender, and ICCC-3 subtype; trends, by average annual percent change (AAPC).

Results

A total of 328 lymphoma cases included in the study had an incidence rate of 11.8, showing a decreasing trend [AAPC: −3.5; CI95% (−5.9, −1.0)], primarily due to non-Hodgkin lymphomas (NHL) and Hodgkin lymphoma (HL) mixed cellularity subtype. NHL had the major incidence (5.8), with the precursor cell subtype being the most frequent (38.3 %). Nodular sclerosis was the most frequent HL subtype. The incidence of Burkitt lymphoma was low (1.3). During the study period, there was an important reduction in the not-otherwise-specified subtype of NHL, which translated into a relative increase in the IIb3 subtype [AAPC: 7.3 (1.2, 13.8)]. Low incidences of NHL and of HL and NHL were found for <1-year-olds and for 10- to 14-year-olds, respectively. Incidence rates for children in the MCMA, particularly the <1 and 10–14 age groups, were lower than those for developed countries. The overall male/female ratio was 2.3.

Conclusions

There was a trend toward a reduced incidence, for some lymphoma subtypes, in particular for NOS lymphomas, which may be the result of improvement in diagnostic techniques.

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References

  1. Estlin E, Gilbertson RJ, Wynn R (2010) Pediatric hematology and oncology: scientific principles and clinical practice. Wiley-Blackwell, Chichester

    Book  Google Scholar 

  2. Howlader N, Noone A, Krapcho M, et al (2014) SEER cancer statistics review, 1975–2011. National Cancer Institute, Bethesda, MD. http://seer.cancer.gov/csr/1975_2011/

  3. Fajardo-Gutiérrez A, Juárez-Ocaña S, González-Miranda G et al (2007) Incidence of cancer in children residing in ten jurisdictions of the Mexican Republic: importance of the Cancer registry (a population-based study). BMC Cancer 7:68. doi:10.1186/1471-2407-7-68

    Article  PubMed Central  PubMed  Google Scholar 

  4. Steliarova-Foucher E, Stiller C, Lacour B, Kaatsch P (2005) International classification of childhood cancer, third edition. Cancer 103:1457–1467. doi:10.1002/cncr.20910

    Article  PubMed  Google Scholar 

  5. Fritz AG (2000) International classification of diseases for oncology: ICD-O, 3rd edn. World Health Organization, Geneva

    Google Scholar 

  6. Moreno F, Loria D, Abriata G et al (2013) Childhood cancer: incidence and early deaths in Argentina, 2000–2008. Eur J Cancer Oxf Engl 1990 49:465–473. doi:10.1016/j.ejca.2012.08.001

    Google Scholar 

  7. de Ferreira JM de O, Klumb CE, de Souza Reis R et al (2012) Lymphoma subtype incidence rates in children and adolescents: first report from Brazil. Cancer Epidemiol 36:e221–226. doi:10.1016/j.canep.2012.03.006

    Article  PubMed  Google Scholar 

  8. González García H, Quirós AB, Crespo CV et al (2010) Incidence of childhood cancer in the autonomous region of Castilla y León in Spain (2003–2007). An Pediatría Barc Spain 2003(73):169–179. doi:10.1016/j.anpedi.2010.07.003

    Article  Google Scholar 

  9. Srina A, Jetsrisuparb A, Komvilaisak P et al (2010) Trends in incidence of childhood lymphoma in Khon Kaen, Thailand, 1985–2008. Asian Pac J Cancer Prev APJCP 11:1683–1686

    Google Scholar 

  10. Lacour B, Guyot-Goubin A, Guissou S et al (2010) Incidence of childhood cancer in France: National Children Cancer Registries, 2000–2004. Eur J Cancer Prev Off J Eur Cancer Prev Organ ECP 19:173–181

    Article  Google Scholar 

  11. Sant M, Allemani C, Tereanu C et al (2010) Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood 116:3724–3734. doi:10.1182/blood-2010-05-282632

    Article  CAS  PubMed  Google Scholar 

  12. Petridou ET, Dimitrova N, Eser S et al (2013) Childhood leukemia and lymphoma: time trends and factors affecting survival in five Southern and Eastern European Cancer Registries. Cancer Causes Control CCC 24:1111–1118. doi:10.1007/s10552-013-0188-y

    Article  PubMed  Google Scholar 

  13. Morton LM, Wang SS, Devesa SS et al (2006) Lymphoma incidence patterns by WHO subtype in the United States, 1992–2001. Blood 107:265–276. doi:10.1182/blood-2005-06-2508

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Baris D, Zahm SH (2000) Epidemiology of lymphomas. Curr Opin Oncol 12:383–394

    Article  CAS  PubMed  Google Scholar 

  15. Ekström-Smedby K (2006) Epidemiology and etiology of non-Hodgkin lymphoma—a review. Acta Oncol Stockh Swed 45:258–271. doi:10.1080/02841860500531682

    Article  Google Scholar 

  16. McNally RJQ, Cairns DP, Eden OB et al (2001) Examination of temporal trends in the incidence of childhood leukaemias and lymphomas provides aetiological clues. Leukemia 15:1612–1618

    Article  CAS  PubMed  Google Scholar 

  17. INEGI (Instituto Nacional de Estadística y Geografía) (2013) Censo de Población y Vivienda 2010. Conjunto de datos: Población total [Population and Housing Census 2010]. http://www.inegi.org.mx/sistemas/olap/Proyectos/bd/censos/cpv2010/PT.asp?s=est&c=27770&proy=cpv10_pt. Accessed 12 Feb 2014

  18. Instituto Mexicano del Seguro Social (IMSS) (2012) Coordinación de Atención Médica. Estructura de Población Adscrita a Médico Familiar, 1996–2010

  19. Kim HJ, Fay MP, Feuer EJ, Midthune DN (2000) Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 19:335–351

    Article  CAS  PubMed  Google Scholar 

  20. Marcos-Gragera R, Cervantes-Amat M, Vicente ML et al (2010) Population-based incidence of childhood leukaemias and lymphomas in Spain (1993–2002). Eur J Cancer Prev Off J Eur Cancer Prev Organ ECP 19:247–255. doi:10.1097/CEJ.0b013e328339e2f3

    Article  Google Scholar 

  21. Bazzeh F, Rihani R, Howard S, Sultan I (2010) Comparing adult and pediatric Hodgkin lymphoma in the surveillance, epidemiology and end results program, 1988–2005: an analysis of 21,734 cases. Leuk Lymphoma 51:2198–2207. doi:10.3109/10428194.2010.525724

    Article  PubMed  Google Scholar 

  22. Kaatsch P (2010) Epidemiology of childhood cancer. Cancer Treat Rev 36:277–285. doi:10.1016/j.ctrv.2010.02.003

    Article  PubMed  Google Scholar 

  23. Wilkinson JD, Gonzalez A, Wohler-Torres B et al (2005) Cancer incidence among Hispanic children in the United States. Rev Panam Salud Pública Pan Am J Public Health 18:5–13

    Article  Google Scholar 

  24. Yao JJA, Couitchere L, Atimere Y et al (2013) Childhood cancer in Côte d’Ivoire, 1995–2004: challenges and hopes. South Afr Med J Suid-Afr Tydskr Vir Geneeskd 103:113–115

    CAS  Google Scholar 

  25. Manipadam MT, Nair S, Viswabandya A et al (2011) Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India. World J Pediatr WJP 7:318–325. doi:10.1007/s12519-011-0303-7

    Article  Google Scholar 

  26. Wiangnon S, Veerakul G, Nuchprayoon I et al (2011) Childhood cancer incidence and survival 2003–2005, Thailand: study from the Thai Pediatric Oncology Group. Asian Pac J Cancer Prev APJCP 12:2215–2220

    Google Scholar 

  27. Fajardo-Gutiérrez A (2011) Evaluation of quality in a cancer registry. Rev Médica Inst Mex Seguro Soc 49(Suppl 1):S121–124

    Google Scholar 

  28. Stefan DC, Wessels G, Poole J et al (2011) Infection with human immunodeficiency virus-1 (HIV) among children with cancer in South Africa. Pediatr Blood Cancer 56:77–79. doi:10.1002/pbc.22672

    Article  PubMed  Google Scholar 

  29. Tukei VJ, Kekitiinwa A, Beasley RP (2011) Prevalence and outcome of HIV-associated malignancies among children. AIDS Lond Engl 25:1789–1793. doi:10.1097/QAD.0b013e3283498115

    Article  Google Scholar 

  30. Mejía-Aranguré JM, Bonilla M, Lorenzana R et al (2005) Incidence of leukemias in children from El Salvador and Mexico City between 1996 and 2000: population-based data. BMC Cancer 5:33. doi:10.1186/1471-2407-5-33

    Article  PubMed Central  PubMed  Google Scholar 

  31. U.S. Cancer Statistics Working Group (2014) United States cancer statistics: 1999–2011 incidence and mortality web-based report, Atlanta

  32. Stiller CA (2004) Epidemiology and genetics of childhood cancer. Oncogene 23:6429–6444. doi:10.1038/sj.onc.1207717

    Article  CAS  PubMed  Google Scholar 

  33. Michel G, von der Weid NX, Zwahlen M et al (2007) The Swiss Childhood Cancer Registry: rationale, organisation and results for the years 2001–2005. Swiss Med Wkly 137:502–509

    PubMed  Google Scholar 

  34. Michel G, von der Weid NX, Zwahlen M et al (2008) Incidence of childhood cancer in Switzerland: the Swiss Childhood Cancer Registry. Pediatr Blood Cancer 50:46–51. doi:10.1002/pbc.21129

    Article  CAS  PubMed  Google Scholar 

  35. Mani H, Jaffe ES (2009) Hodgkin lymphoma: an update on its biology with new insights into classification. Clin Lymphoma Myeloma 9:206–216. doi:10.3816/CLM.2009.n.042

    Article  PubMed Central  PubMed  Google Scholar 

  36. Gualco G, Klumb CE, Barber GN et al (2010) Pediatric lymphomas in Brazil. Clin São Paulo Braz 65:1267–1277

    Article  Google Scholar 

  37. Aka P, Kawira E, Masalu N et al (2012) Incidence and trends in Burkitt lymphoma in northern Tanzania from 2000 to 2009. Pediatr Blood Cancer 59:1234–1238. doi:10.1002/pbc.24194

    Article  PubMed Central  PubMed  Google Scholar 

  38. Kulkarni K, Stobart K, Witol A, Rosychuk RJ (2011) Leukemia and lymphoma incidence in children in Alberta, Canada: a population-based 22-year retrospective study. Pediatr Hematol Oncol 28:649–660. doi:10.3109/08880018.2011.613091

    Article  PubMed  Google Scholar 

  39. Macfarlane GJ, Evstifeeva T, Boyle P, Grufferman S (1995) International patterns in the occurrence of Hodgkin’s disease in children and young adult males. Int J Cancer 61:165–169

    Article  CAS  PubMed  Google Scholar 

  40. Koh YW, Kang HJ, Yoon DH et al (2013) Changing trend of Epstein–Barr virus association in Hodgkin lymphoma in the Republic of Korea. Ann Hematol 92:1653–1660. doi:10.1007/s00277-013-1837-7

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The authors thank the personnel of the Mexican Childhood Cancer Registry and José Darío Martínez-Ezquerro for their aid in the review of the collected information and Veronica Yakoleff for translation and editing of the manuscript and for helpful comments. This research was funded by Fondo de Investigación en Salud del Instituto Mexicano del Seguro Social, reg. FIS/IMSS/PROT/G13/1199.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Unidad de Investigación en Epidemiología Clínica, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, D.F., Mexico

    Mario Enrique Rendón-Macías & Arturo Fajardo-Gutiérrez

  2. Escuela de Medicina, Universidad Panamericana, Mexico City, D.F., Mexico

    Mario Enrique Rendón-Macías, Edwin A. Valencia-Ramón & Estefanía Rivera-Flores

  3. Registro de Cáncer en Niños, Unidad de Investigación en Epidemiología Clínica, Unidad Médica de Alta Especialidad Hospital de Pediatría del Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Avenida Cuauhtémoc 330 Col. Doctores, C.P. 06720, Mexico, D.F., Mexico

    Arturo Fajardo-Gutiérrez

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  1. Mario Enrique Rendón-Macías
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  2. Edwin A. Valencia-Ramón
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Correspondence to Arturo Fajardo-Gutiérrez.

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Rendón-Macías, M.E., Valencia-Ramón, E.A., Fajardo-Gutiérrez, A. et al. Childhood lymphoma incidence patterns by ICCC-3 subtype in Mexico City metropolitan area population insured by Instituto Mexicano del Seguro Social, 1996–2010. Cancer Causes Control 26, 849–857 (2015). https://doi.org/10.1007/s10552-015-0558-8

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