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Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India

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Abstract

Background

There is a dearth of published literature on the frequency and distribution of pediatric and adolescent non-Hodgkin lymphoma (NHL) in India according to the 2001 WHO classification. The aim of this study was to record the distribution of the different subtypes, analyze the major subtypes, and compare it with the published data from other countries. A review of pediatric NHL statistics from population-based cancer registries was included in this study.

Methods

The study was conducted using information retrieved from the files of our institution. A total of 467 patients with lymphoma (excluding mycosis fungoides) were recorded in the under 20 years group over a period of 6 years, of which 252 patients suffered from NHL. The demographic characteristics, frequency and distribution of different subtypes were noted and compared with published reports from other parts of the world.

Results

T-lymphoblastic lymphoma/leukemia constituted the majority (32.1%) of all NHLs in children and adolescents in our study. The other major subgroups were Burkitt’s lymphoma, anaplastic large cell lymphoma, and diffuse large B cell lymphoma. Burkitt’s lymphoma in this study had clinical presentations similar to those seen in western countries.

Conclusions

The distribution of different subtypes of lymphoma in pediatric and adolescent NHL in India differs considerably from that in western countries and other eastern countries.

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References

  1. Stiller CA. International patterns of cancer incidence in adolescents. Cancer Treat Rev 2007;33:631–645.

    Article  PubMed  Google Scholar 

  2. Gross TG, Termuhlen AM. Pediatric non-Hodgkin’s lymphoma. Curr Oncol Rep 2007;9:459–465.

    Article  PubMed  CAS  Google Scholar 

  3. Kaplinsky C, Zaizov R. Childhood B-cell non-Hodgkin’s lymphoma in Israel. Leuk Lymphoma 1994;14:49–53.

    Article  PubMed  CAS  Google Scholar 

  4. Samuelsson BO, Ridell B, Rockert L, Gustafsson G, Marky I. Non-Hodgkin lymphoma in children: a 20 year population based epidemiologic study in Western Sweden. J Pediatr Hematol Oncol 1999;21:87–88.

    Article  Google Scholar 

  5. Swaminathan R, Rama R, Shanta V. Childhood cancers in Chennai, India, 1990–2001: incidence and survival. Int J Cancer 2008;122:2607–2611.

    Article  PubMed  CAS  Google Scholar 

  6. Kusumakumary P, Sankaranarayanan R, Padmakumary G, Varghese C, Kumar SR, Nair MK. Childhood cancer in Kerala, India. Lancet 1991;338:455–456.

    Article  PubMed  CAS  Google Scholar 

  7. Arya LS. Childhood cancer: where do we stand? Indian Pediatr 1997;34:583–587.

    PubMed  CAS  Google Scholar 

  8. Kusumakumary P, Jacob R, Jothirmayi R, Nair MK. Profile of pediatric malignancies: a ten year study. Indian Pediatr 2000;37:1234–1238.

    PubMed  CAS  Google Scholar 

  9. Wright D, McKeever P, Carter R. Childhood non-Hodgkin lymphomas in the United Kingdom: findings from the UK Children’s Cancer Study Group. J Clin Pathol 1997;50:128–134.

    Article  PubMed  CAS  Google Scholar 

  10. Srinivas V, Soman CS, Naresh KN. Study of the distribution of 289 non-Hodgkin lymphoma using the WHO classification among children and adolescents of India. Med Pediatr Oncol 2002;39:40–43.

    Article  PubMed  CAS  Google Scholar 

  11. Sachdev KN, Kalra VB, Ramdeo IN, Sachdev J. Malignant lymphoma in childhood. Indian J Pediatr 1973;40:188–192.

    Article  PubMed  CAS  Google Scholar 

  12. Desai MP, Merchant SM. Lymphosarcoma in childhood. Indian Pediatrics 1970;7:506–514.

    PubMed  CAS  Google Scholar 

  13. Nandakumar A, Anantha N, Appaji L, Swamy K, Mukherjee G, Venugopal T, et al. Descriptive epidemiology of childhood cancers in Bangalore, India. Cancer Causes Control 1996;7:405–410.

    Article  PubMed  CAS  Google Scholar 

  14. Parkin DM, Stiller CA, Draper GJ, Bieber CA. The international incidence of childhood cancer. Int J Cancer 1988;42:511–520.

    Article  PubMed  CAS  Google Scholar 

  15. Banerjee CK, Srinivas M, Goswami KC, Pathak IC, Walia BN. Non-Hodgkin’s lymphoma in children—histopathologic classification in relation to age and sex. Indian J Pediatr 1983;50:511–514.

    Article  PubMed  CAS  Google Scholar 

  16. Pedrosa MF, Pedrosa F, Lins MM, Pontes Neto NT, Falbo GH. Non-Hodgkin’s lymphoma in childhood: clinical and epidemiological characteristics and survival analysis at a single center in Northeast Brazil. J Pediatr (Rio J) 2007;83:547–554.

    Article  Google Scholar 

  17. Burkhardt B, Zimmermann M, Oschlies I, Niggli F, Mann G, Parwaresch R, et al. The impact of age and gender on biology, clinical features and treatment outcome of non-Hodgkin lymphoma in childhood and adolescence. Br J Haematol 2005;131:39–49.

    Article  PubMed  Google Scholar 

  18. Hwang IG, Yoo KH, Lee SH, Park YH, Lim TK, Lee SC, et al. Clinicopathologic features and treatment outcomes in malignant lymphoma of pediatric and young adult patients in Korea: comparison of korean all-ages group and Western younger age group. Clin Lymphoma Myeloma 2007;7:580–586.

    Article  PubMed  Google Scholar 

  19. Sukpanichnant S. Analysis of 1983 cases of malignant lymphoma in Thailand according to the World Health Organisation Classification. Human Pathology 2004;35:224–230.

    Article  PubMed  Google Scholar 

  20. Percy CL, Smith MA, Linet M, Gloeckler Ries LA, Friedman DL. Lymphoma and reticuloendothelial neoplasms. In: Ries LAG, Smith MA, Gurney JG, Linet M, Tamra T, Young JL, et al (eds). Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995. Bethesda: ICCCII, 1999: 35–50.

    Google Scholar 

  21. Naresh KN, Agarwal B, Nathwani BN, Diebold J, McLennan KA, Muller-Hermelink KH. Use of the WHO classification of non-Hodgkin’s lymphoma in Mumbai, India: a review of 200 consecutive cases by a panel of five expert hematopathologists. Leuk Lymphoma 2004;45:1569–1577.

    Article  PubMed  Google Scholar 

  22. Naresh KN, Srinivas V, Soman CS. Distribution of various subtypes of non-Hodgkin’s lymphoma in India: a study of 2773 lymphomas using R.E.A.L. and WHO Classifications. Ann Oncol 2000;11(Suppl 1):S63–S67.

    Article  Google Scholar 

  23. The non-Hodgkin’s Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group Classification of Non-Hodgkin’s lymphoma. Blood 1997;89:3909–3918.

    Google Scholar 

  24. Chuang SS, Lin CN, Li CY. Malignant lymphoma in Southern Taiwan according to the Revised European-American classification of lymphoid neoplasm. Cancer 2000;89:1586–1592.

    Article  PubMed  CAS  Google Scholar 

  25. Naresh KN, Advani S, Adde M, Aziz Z, Banavali S, Bhatia K, et al. Report of an International Network of Cancer Treatment and Research Workshop on non-Hodgkin’s lymphoma in developing countries. Blood Cells Mol Dis 2004;33:330–337.

    Article  PubMed  CAS  Google Scholar 

  26. Sasikala PS, Nirmala K, Sundersingh S, Mahji U, Rajkumar T. Frequency and distribution of Epstein-Barr virus infection and its association with p53 expression in a series of primary nodal non-Hodgkin lymphoma patients from South India. Int J Lab Haematol 2010;32(1 Pt 2):56–64.

    Article  CAS  Google Scholar 

  27. Sehgal S, Mujtaba S, Gupta D, Aggarwal R, Marwaha RK. High incidence of EBV infection in childhood acute lymphoblastic leukemia: a preliminary study. Indian J Pathol Microbiol 2010;53:63–67.

    Article  PubMed  CAS  Google Scholar 

  28. Sadananda Adiga MN, Chandy S, Ramachandra N, Appaji L, Aruna Kumari BS, Ramaswamy G, et al. Methylenetetrahydrofolate reductase gene polymorphisms and risk of acute lymphoblastic leukemia in children. Indian J Cancer 2010;47:40–45.

    Article  PubMed  CAS  Google Scholar 

  29. Sudhakar N, Nirmala K, Rajalekshmy KR, Rajkumar T. Does Tal-1 deletion contribute to high incidence of T-cell ALL in South Indian patients? Asian Pac J Cancer Prev 2008;9:127–130.

    PubMed  CAS  Google Scholar 

  30. Diebold J, Jaffe ES, Raphael M, Warnke RA. Burkitt lymphoma. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, eds. WHO Classification of Tumours. Pathology and Genetics of Hematolymphoid Tumours. Lyon, France: IARC, 2001: 181–184.

    Google Scholar 

  31. Bosco JIE, Appaji L, Aruna K, Raghuram P, Rama Rao C, Vidhya A. Clinical and radiological features of paediatric Burkitt’s lymphoma—a four year study. Indian J Med Paediatr Oncol 2007;28:14–17.

    Google Scholar 

  32. Choudhry VP, Agarwal RK, Marwah RK. Characteristics of Burkitt’s lymphoma in India. Indian J Pediatr 1987;54:859–862.

    Article  PubMed  CAS  Google Scholar 

  33. Frost M, Newell J, Lones MA, Tripp SR, Cairo MS, Perkins SL. Comparative immunohistochemical analysis of pediatric Burkitt lymphoma and diffuse large B cell lymphoma. Am J Clin Pathol 2004;121:384–392.

    Article  PubMed  Google Scholar 

  34. Murphy SB. Pediatric lymphoma: recent advances and commentary on Ki-1-positive anaplastic large-cell lymphomas of childhood. Ann Oncol 1994;5(Suppl 1):S31–S33.

    Google Scholar 

  35. d’Amore ES, Menin A, Bonoldi E, Bevilacqua P, Cazzavillan S, Donofrio V, et al. Anaplastic large cell lymphomas: a study of 75 pediatric patients. Pediatr Dev Pathol 2007;10:181–191.

    Article  PubMed  Google Scholar 

  36. Oschlies I, Klapper W, Zimmermann M, Krams M, Wacker HH, Burkhardt B, et al. Diffuse large B-cell lymphoma in pediatric patients belongs predominantly to the germinal-center type B-cell lymphomas: a clinicopathologic analysis of cases included in the German BFM (Berlin-Frankfurt-Münster) Multicenter Trial. Blood 2006;107:4047–4052.

    Article  PubMed  CAS  Google Scholar 

  37. Windsor R, Stiller C, Webb D. Peripheral T cell lymphoma in childhood: population based experience in the United Kingdom over 20 years. Pediatr Blood Cancer 2008;50:784–787.

    Article  PubMed  Google Scholar 

  38. Swerdlow SH. Pediatric follicular lymphomas, marginal zone lymphomas and marginal zone hyperplasia. Am J Clin Pathol 2004;122(Suppl 1):S98–S109.

    PubMed  Google Scholar 

  39. Taddesse-Heath L, Pittaluga S, Sorbara L, Bussey M, Raffeld M, Jaffe ES. Marginal zone B-cell lymphoma in children and young adults. Am J Surg Pathol 2003;27:522–531.

    Article  PubMed  Google Scholar 

  40. Marky I, Schmiegelow K, Perkkio M, Jonsson OG, Storm-Mathiesen I, Gustafsson G, et al. Childhood non-Hodgkin’s lymphoma in the five Nordic countries. A five year population based study from the Nordic Society of Pediatric Hematology and Oncology. J Pediatr Hematol Oncol 1995;17:163–166.

    Article  PubMed  CAS  Google Scholar 

  41. Petridou ET, Pourtsidis A, Dessypris N, Katsiardanis K, Baka M, Moschovi M, et al. Childhood leukaemias and lymphomas in Greece (1996–2006): a nationwide registration study. Arch Dis Child 2008;93:1027–1032.

    Article  PubMed  CAS  Google Scholar 

  42. Echimane AK, Ahnoux AA, Adoubi I, Hien S, M’Bra K, D’Horpock A, et al. Cancer incidence in Abidjan, Ivory Coast: first results from the cancer registry, 1995–1997. Cancer 2000;89:653–663.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Christian Medical College, Vellore, India

    Marie Therese Manipadam & Sheila Nair

  2. Department of Hematology, Christian Medical College, Vellore, India

    Auro Viswabandya, Alok Srivastava & Mammen Chandy

  3. Department of Child Health, Christian Medical College, Vellore, India

    Leni Mathew

  4. Department of Pathology, Christian Medical College, Vellore, 632004, Tamil Nadu, India

    Marie Therese Manipadam

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  1. Marie Therese Manipadam
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  2. Sheila Nair
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Correspondence to Marie Therese Manipadam.

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Manipadam, M.T., Nair, S., Viswabandya, A. et al. Non-Hodgkin lymphoma in childhood and adolescence: frequency and distribution of immunomorphological types from a tertiary care center in South India. World J Pediatr 7, 318–325 (2011). https://doi.org/10.1007/s12519-011-0303-7

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