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Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: a cohort study of 10,612 women in Taiwan

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Abstract

This study aimed at assessing the association between the type-specific human papillomavirus (HPV) infection and the risk of adenocarcinoma of the rectum and recto-sigmoid junction. A total of 10,612 women aged 30–65 years old were enrolled from seven townships in Taiwan. Cervical cells collected at study entry were tested for 39 types of HPV infection by polymerase chain reactions and HPV blot kit. Newly developed adenocarcinomas of rectum and recto-sigmoid junction were ascertained through computerized linkage with national cancer registry profiles. An increased risk of adenocarcinomas of the rectum and recto-sigmoid junction was observed with HPV infection, showing a hazard ratio [HR] (95% confidence interval [CI]) of 1.99 (0.98–4.04) after adjustment for age and body mass index. The adjusted HR (95% CI) for the infection of HPV types other than 6 and 11 was 2.18 (1.04–4.60). Women with cervical infection of HPV types other than 6 and 11 at study entry may have an increased risk of adenocarcinomas of the rectum and recto-sigmoid junction, which deserves further validation by large-scale studies.

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Acknowledgments

This work was supported by Health Promotion Bureau, Department of Health (Grant no: 93-028) and National Science Council (Grant no: NSC-93-2320-B-002-011 & NSC-94-2314-B-001-011).

Conflict of interest statement

All authors of this research paper have not any financial and personal relationships with other people or organizations that could inappropriately influence our work such as employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding.

Funding

This work was supported by Health Promotion Bureau, Department of Health (Grant no: 93-028) and National Science Council (Grant no: NSC-93-2320-B-002-011 & NSC-94-2314-B-001-011).

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Authors and Affiliations

  1. Graduate Institute of Life Sciences, National Defense Medical Center, 16, Min-Chuan East Road, Section 6, 114, Taipei, Taiwan

    Li-Chung Chuang

  2. Genomics Research Center, Academia Sinica, 128, Academia Road, Section 2, 115, Taipei, Taiwan

    Li-Chung Chuang, Hui-Chi Chen, San-Lin You, Mei-Hung Pan & Chien-Jen Chen

  3. Graduate Institute of Epidemiology, National Taiwan University, 17, Xu-Zhou Road, 100, Taipei, Taiwan

    Hui-Chi Chen, Yi-Chun Chou & Chien-Jen Chen

  4. Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University, 250, Wu-Hsing Street, 110, Taipei, Taiwan

    Ching-Yu Lin

  5. Department of Obstetrics & Gynaecology, National Taiwan University Hospital, 7, Chung-Shan South Road, 100, Taipei, Taiwan

    Chang-Yao Hsieh

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  1. Li-Chung Chuang
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  2. Hui-Chi Chen
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  8. Chien-Jen Chen
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Correspondence to Chien-Jen Chen.

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Chuang, LC., Chen, HC., You, SL. et al. Association between human papillomavirus and adenocarcinoma of rectum and recto-sigmoid junction: a cohort study of 10,612 women in Taiwan. Cancer Causes Control 21, 2123–2128 (2010). https://doi.org/10.1007/s10552-010-9631-5

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  • DOI: https://doi.org/10.1007/s10552-010-9631-5

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