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Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)

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Abstract

Objective:

To determine the relationship of body mass index (BMI) and BMI changes during adulthood to lung cancer mortality in a large-sized Japanese cohort.

Methods:

We followed 29,350 men for a maximum of 11 years in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated from 1988 to 1990. Complementary log–log modeling was employed with age, smoking status, and family history of lung cancer as covariates. Anthropometric measurements used were BMI at baseline, BMI around age 20, and adulthood BMI loss defined between the two measurements. Independent effects of these three measurements on lung cancer mortality were evaluated by applying the method of generalized estimation equations to the model for adjustment of intra-individual correlation.

Results:

Never smokers showed that high BMI both at baseline and around age 20 significantly predict lung cancer mortality (P < 0.05). Adulthood BMI loss significantly (P < 0.05) elevated the risk for lung cancer mortality among current smokers, implying their enhanced vulnerability to lung cancer risk among smokers.

Conclusions:

The risk for lung cancer mortality is elevated by a mechanism related to smoking-induced weight loss during adulthood.

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Abbreviations

BMI:

Body mass index

ICD:

International classification of diseases

GEE:

Generalized estimating equations

RR:

Relative risk

CI:

Confidence interval

CVD:

Cardiovascular disease

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Acknowledgments

The authors wish to express their appreciation to Dr. Kunio Aoki, Professor Emeritus, Nagoya University School of Medicine and former chairman of the JACC Study Group, and to Dr. Haruo Sugano, former Director of the Cancer Institute of Japanese Foundation for Cancer Research, both of whom greatly contributed to the initiation of this study. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (C)(2) (No. 12218216) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The JACC Study was also supported by Grants-in-Aid for Scientific Research from the same Ministry (Nos. 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102 and 11181101).

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Authors and Affiliations

  1. Department of Medical Technology, Nagoya University School of Health Sciences, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan

    Takaaki Kondo

  2. Department of Nursing, Nagoya University School of Health Sciences, 1-20 Daikominami 1-chome, Higashi-ku, Nagoya, 461-8673, Japan

    Yoko Hori

  3. Department of Public Health/Health Information Dynamics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Hiroshi Yatsuya, Koji Tamakoshi & Hideaki Toyoshima

  4. Division of Epidemiology, Department of Public Health and Forensic Medicine, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Yoshikazu Nishino

  5. Division of Public Health, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Science, 1-757 Asahimachidori, Niigata, 951-8510, Japan

    Nao Seki

  6. Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Yoshinori Ito, Kenji Wakai & Akiko Tamakoshi

  7. Department of Public Health, Fujita Health University School of Health Sciences, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Koji Suzuki

  8. Department of Social Medicine and Cultural Sciences, Research Institute for Neurological Diseases and Geriatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan

    Kotaro Ozasa & Yoshiyuki Watanabe

  9. Health Service, Kyoto University, Yoshida-Honmachi, Sakyo-ku, Kyoto, 606-0021, Japan

    Masahiko Ando

Authors
  1. Takaaki Kondo
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  2. Yoko Hori
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  3. Hiroshi Yatsuya
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  4. Koji Tamakoshi
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  5. Hideaki Toyoshima
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  6. Yoshikazu Nishino
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  7. Nao Seki
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  8. Yoshinori Ito
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  9. Koji Suzuki
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  10. Kotaro Ozasa
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  11. Yoshiyuki Watanabe
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  12. Masahiko Ando
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  13. Kenji Wakai
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  14. Akiko Tamakoshi
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Corresponding author

Correspondence to Takaaki Kondo.

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Kondo, T., Hori, Y., Yatsuya, H. et al. Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study). Cancer Causes Control 18, 229–234 (2007). https://doi.org/10.1007/s10552-006-0069-8

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  • DOI: https://doi.org/10.1007/s10552-006-0069-8

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