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Advances of neuroimaging in chemotherapy related cognitive impairment (CRCI) of patients with breast cancer

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Abstract

Background

Chemotherapy related cognitive impairment (CRCI) has seriously affected the quality of life (QOL) of patients with breast cancer (BCs), thus the neurobiological mechanism of CRCI attracted widespread attention. Previous studies have found that chemotherapy causes CRCI through affecting brain structure, function, metabolism, and blood perfusion.

Findings

A variety of neuroimaging techniques such as functional magnetic resonance imaging (fMRI), event-related potential (ERP), near-infrared spectroscopy (NIRS) have been widely applied to explore the neurobiological mechanism of CRCI.

Conclusion

This review summarized the progress of neuroimaging research in BCs with CRCI, which provides a theoretical basis for further exploration of CRCI mechanism, disease diagnosis and symptom intervention in the future.

Graphical abstract

Multiple neuroimaging techniques for CRCI research.

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Data Availability

Not applicable.

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Acknowledgements

We thank the web of Pngkey and Pinclipart for providing the picture materials. We thank the authors for the creation of picture materials.

Funding

Funding was supplied by National Natural Science Foundation of China (No. 81872504; 81372487).

Author information

Author notes

  1. Senbang Yao, Qianqian Zhang and Xinxin Yao have contributed equally to this review.

Authors and Affiliations

  1. Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China

    Senbang Yao, Qianqian Zhang, Lulian Pang, Sheng Yu & Huaidong Cheng

  2. Cancer and Cognition Laboratory, Anhui Medical University, Hefei, Anhui, China

    Senbang Yao, Qianqian Zhang, Lulian Pang & Sheng Yu

  3. Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, China

    Xinxin Yao & Xiuqing Zhang

  4. Department of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong, China

    Huaidong Cheng

  5. Shenzhen Clinical Medical School, Southern Medical University, Shenzhen, Guangdong, China

    Huaidong Cheng

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Contributions

HC contributed to the conception of the review. SY, QZ and XY were responsible for searching the literature and writing the manuscript. LP and XZ contributed scientific insights. XY created graphical illustrations. SY and HC contributed to manuscript revision and reviewed the submitted version. All authors contributed to the review and approved the submitted version.

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Correspondence to Huaidong Cheng.

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Yao, S., Zhang, Q., Yao, X. et al. Advances of neuroimaging in chemotherapy related cognitive impairment (CRCI) of patients with breast cancer. Breast Cancer Res Treat 201, 15–26 (2023). https://doi.org/10.1007/s10549-023-07005-y

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  • DOI: https://doi.org/10.1007/s10549-023-07005-y

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