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Utility of 70-kV single-energy CT in depicting the extent of breast cancer for preoperative planning

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Abstract

Purpose

To evaluate the detectability of breast cancer and visibility of the tumor extent using 70-kV single-energy contrast-enhanced (CE) breast computed tomography (70-kV CECT) compared with CE breast magnetic resonance imaging (CEMR).

Methods

Between 2013 and 2015, 110 patients with 112 breast cancer lesions who underwent breast surgery after undergoing both 70-kV CECT and CEMR were enrolled. The major axis lengths of the breast lesion were measured and compared with the pathologically determined major axes. Agreement in the measured major axes was evaluated using the intra-class correlation coefficient (ICC).

Results

Both 70-kV CECT and CEMR depicted all breast cancer lesions. The mean major axis was 3.0 (95% confidence interval [CI], 2.5–3.4) cm on CECT and 2.9 (2.6–3.3) cm on CEMR. The mean differences between the pathologically and radiologically measured major axes on 70-kV CECT and CEMR were 0.9 (0.7–1.1) and 1.0 (0.8–1.2) cm, respectively. The accuracy of the radiological major axes compared with the pathological major axes was 82.1% and 80.4% on CECT and CEMR, respectively (p = 0.81). The major axes on the two modalities demonstrated moderate agreement (ICC = 0.69, 95% CI 0.58–0.77). Pathologically and radiologically measured major axes on 70-kV CECT and CEMR demonstrated excellent agreement (ICC = 0.91, 95% CI 0.93–0.96).

Conclusions

Low-tube voltage (70-kV) CECT is the preferred modality to identify breast cancer lesions and tumor extent for preoperative planning because it has a similar diagnostic ability to CEMR and can be performed in the supine position.

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Authors and Affiliations

  1. Department of Radiology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan

    Marehiko Hisoshima, Misugi Urano, Masaki Ogawa, Shingo Omata & Yuta Shibamoto

  2. Department of Radiology, Nagoya City University Hospital, Kawasumi 1, Mizuhocho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan

    Kazuya Ohashi

  3. Department of Radiology, Nishichita General Hospital, Nakanoike 3-1-1, Tokai, Aichi, 477-8522, Japan

    Shiro Yoshida

  4. Department of Breast Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, 467-8601, Japan

    Tatsuya Toyama

Authors
  1. Marehiko Hisoshima
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  2. Misugi Urano
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  3. Kazuya Ohashi
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  4. Masaki Ogawa
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  5. Shingo Omata
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  6. Shiro Yoshida
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  7. Tatsuya Toyama
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  8. Yuta Shibamoto
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Correspondence to Misugi Urano.

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The authors declare that they have no conflicts of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of our institutional review board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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The requirement for informed consent was waived for this retrospective study, but written informed consent for each examination and possible use of the data for research purposes was received from all patients.

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Hisoshima, M., Urano, M., Ohashi, K. et al. Utility of 70-kV single-energy CT in depicting the extent of breast cancer for preoperative planning. Breast Cancer Res Treat 184, 817–823 (2020). https://doi.org/10.1007/s10549-020-05909-7

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  • DOI: https://doi.org/10.1007/s10549-020-05909-7

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