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Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta-analysis

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Abstract

Purpose

P-cadherin (CDH3), located at 16q22.1 belonging to classical cadherin family, is a calcium-dependent glycoprotein associated with cell to cell adhesion, migration, and invasion in cancer. This meta-analysis was conducted to examine the prognostic utility of P-cadherin expression in breast cancer (BC).

Methods

A comprehensive literature search was carried out using the available databases to obtain relevant research articles to test the relationship between P-cadherin and BC. Correlation of P-cadherin expression and disease-free survival (DFS) or overall survival (OS) was tested using hazard ratio (HR), relative risk (RR) at 95% confidence interval (CI) by univariate and/or multivariate analysis. A total of 11 studies from 7 countries were found to be relevant and were further subjected to statistical analysis to find an association between the P-cadherin expression with BC. Additionally, we have also performed a co-relation analysis of P-cadherin expression with GOBO and Cancertool in breast cancer using publicly available breast cancer datasets.

Results

Our study shows that P-cadherin expression is significantly linked with poor prognosis in the various subtypes of BC. The HR for OS and DFS was 1.87 (95% CI = 1.48–2.36) and 1.64 (95% CI = 1.18–2.27) respectively.

Conclusions

In this meta-analysis, we identified a positive correlation between the overexpression of P-cadherin and BC. Our study demonstrates that P-cadherin overexpression can be used as a prognostic indicator in BC.

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Acknowledgement

We thank Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India (Grant No: EMR/2016/002314) and Department of Biotechnology (DBT), Government of India (6242-P8/RGCB/PMD/DBT/SPDK/2015, BT/PR2423/AGR/36/700/2011) for financial support. The authors acknowledge the support from TIFAC CORE in Pharmacogenomics, Government of India; DST-FIST, Government of India for infrastructure support and Manipal Academy of Higher Education (MAHE) for TMA Pai structured Ph.D. fellowships. The funding source had no involvement in the conduct of the research and/or preparation of this article.

Funding

Funding

This study was funded by Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India (Grant No: EMR/2016/002314) and Department of Biotechnology (DBT), Government of India (6242-P8/RGCB/PMD/DBT/SPDK/2015, BT/PR2423/AGR/36/700/2011). The funding source had no involvement in the conduct of the research and/or preparation of this article.

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  1. Sriya Sridhar and Christabelle Rajesh have contributed equally to this work.

Authors and Affiliations

  1. Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, 576104, India

    Sriya Sridhar, Christabelle Rajesh, Padacherri Vethil Jishnu, Pradyumna Jayaram & Shama Prasada Kabekkodu

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  1. Sriya Sridhar
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Correspondence to Shama Prasada Kabekkodu.

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Authors Sriya Sridhar, Christabelle Rajesh, Padacherri Vethil Jishnu, Pradyumna Jayaram and Shama Prasada Kabekkodu declare that they have no conflict of interest.

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Sridhar, S., Rajesh, C., Jishnu, P.V. et al. Increased expression of P-cadherin is an indicator of poor prognosis in breast cancer: a systematic review and meta-analysis. Breast Cancer Res Treat 179, 301–313 (2020). https://doi.org/10.1007/s10549-019-05477-5

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