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High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas

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Abstract

We analyzed the expression of several microRNAs (miRs) implicated in breast cancer (BC) pathogenesis (miR-21, miR-10b, miR17-5p, mir-31, miR-155, miR-200c, miR-18a, miR-205, and miR-27a) in 80 breast carcinomas obtained from patients with bilateral BC (biBC) and 40 cases of unilateral BC (uBC). Unexpectedly, three miRs (miR-21, miR-10b and miR-31) demonstrated significantly higher level of expression in biBC vs. uBC (P = 0.0001, 0.00004 and 0.0002, respectively). Increased contents of miR-21, miR-10b and miR-31 were observed in all categories of biBC tumors, i.e., in synchronous biBC as well as in first and second tumors from metachronous biBC cases. Synchronous biBC showed more similarity of miR expression profiles within pairs that the metachronous doublets (P = 0.004). This study suggests that bilateral breast tumors have somewhat distinct pattern of molecular events as compared to the unilateral disease.

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Acknowledgments

This study has been supported by the Russian Federation for Basic Research (grants 10-04-92110, 10-04-00260, 11-04-00227 and 11-04-01643), the Japanese Society for the Promotion of Science (JSPS) (project 10037711), the Federal Agency for Science and Innovations (contract 02.740.11.0780), the Commission of the European Communities (grant PITN-GA-2009-238132), and the Government of Moscow (grant 15/11).

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Authors and Affiliations

  1. Laboratory of Molecular Oncology, N. N. Petrov Institute of Oncology, Pesochny-2, 197758, St.-Petersburg, Russia

    Aglaya G. Iyevleva, Ekatherina Sh. Kuligina, Nathalia V. Mitiushkina, Alexandr V. Togo & Evgeny N. Imyanitov

  2. Department of Medical Genetics, St.-Petersburg Pediatric Medical Academy, St.-Petersburg, Russia

    Aglaya G. Iyevleva & Evgeny N. Imyanitov

  3. Department of Genetic Diagnosis, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan

    Yoshio Miki

  4. Department of Oncology, St.-Petersburg Medical Academy for Postgraduate Studies, St.-Petersburg, Russia

    Evgeny N. Imyanitov

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  1. Aglaya G. Iyevleva
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  2. Ekatherina Sh. Kuligina
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  3. Nathalia V. Mitiushkina
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  4. Alexandr V. Togo
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  5. Yoshio Miki
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  6. Evgeny N. Imyanitov
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Correspondence to Evgeny N. Imyanitov.

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Iyevleva, A.G., Kuligina, E.S., Mitiushkina, N.V. et al. High level of miR-21, miR-10b, and miR-31 expression in bilateral vs. unilateral breast carcinomas. Breast Cancer Res Treat 131, 1049–1059 (2012). https://doi.org/10.1007/s10549-011-1845-z

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  • DOI: https://doi.org/10.1007/s10549-011-1845-z

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