Abstract
Human breast cancer incidence has seasonal patterns that seem to vary among global populations. The aggregate monthly frequency of breast cancer diagnosis was collected and examined for 2,921,714 breast cancer cases diagnosed across 64 global regions over spans from 2 to 53 years. Breast cancer is consistently diagnosed more often in spring and fall, both in the Northern and Southern Hemispheres, regardless of presumable menopausal status (≤50, >50). This seasonality is increasingly more prominent as population distance from the equator increases and this latitude dependence is most pronounced among women living in rural areas. Moreover, the overall annual incidence (2005–2006), per 100,000 population, of breast cancer increased as the latitude of population residence increased. These data make it clear that human breast cancer discovery occurs non-randomly throughout each year with peaks near both equinoxes and valleys near both solstices. This stable global breast cancer seasonality has implications for better prevention, more accurate screening, earlier diagnosis, and more effective treatment. This complex latitude-dependent breast cancer seasonality is clearly related to predictable local day/night length changes which occur seasonally. Its mechanism may depend upon seasonal sunlight mediation of vitamin D and seasonal mediation of nocturnal melatonin peak level and duration.
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Acknowledgments
Person(s) who helped us obtain the data from each cancer registry: Belgium (Jos Droste), Canada (Alain Demers), Chile (Maria Enriqueta Betran Vives), Shanghai-China (Chung-Xiao Wu), Colorado-US (Randi Rycroft), Czech Republic (Vlasta Mazankova), England-Oxford (Neil Kennedy), Estonia (Margit Mägi and Mati Rahu), Finland (Timo Hakulinen), Iceland (Laufey Tryggvadóttir), Idaho-US (Stacey L. Carson), Indiana-US (Steve Nygaard), Iran (Seyed Mohsen Mousavi), Ireland (Harry Comber), Israel (Micha Barchana), Lithuania (Juozas Kurtinatis), Massachusetts-US (Susan Gershman), Michigan-US (Georgia Spivak), Montana-US (Debbi Lemons), New Orleans-US (Patty Andrews), New York-US (Maria J. Schymura), New Zealand (Susan Hanna), Northern Australia (Lindy Garling), Northern Ireland (Anna T. Gavin), Norway (Froydis Langmark), Oregon-US (Donald Shipley), Philipines (Ronald De los Reyes), Poland (Zwierko Maria), Rhode Island-US (John Fulton), Scotland (David Brewster), South Carolina-US (DHEC), Taiwan (CJ Chen and San-Lin You), Tasmania (Alison Venn), Texas-US (Melanie Williams), Lampang-Thailand (Nilubol Patel), Songkhla-Thailand (Hutcha Sriplung), Vermont-US (Ali Johnson), Western Australia (Timothy J. Threlfall), and Wisconsin-US (Laura Stephenson).
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Oh, EY., Ansell, C., Nawaz, H. et al. Global breast cancer seasonality. Breast Cancer Res Treat 123, 233–243 (2010). https://doi.org/10.1007/s10549-009-0676-7
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DOI: https://doi.org/10.1007/s10549-009-0676-7