Abstract
Cytokines are promising agents for cancer therapy due to their activity at low concentrations. We used a naked IL-12 DNA expression vector to achieve long-term systemic cytokine expression to inhibit breast tumor growth in MMTVneu transgenic and transplanted models. Constant low levels of IL-12 produced by this protocol provided effective tumor growth inhibition of both tumor models without adverse effects.
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Acknowledgments
We are indebted to Dario Strina (ITB, CNR) for assistance with the studies on SCID mice. These studies were funded by the AIRC, Ricerca Finalizzata IRCSS, the FIRB and the MUIR PRIN. This is manuscript no. 88 of the Genoma 2000/ITB Project funded by CARIPLO.
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Douglas M. Noonan, Maria Grazia Sacco equally contributed to these studies.
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Faggioli, F., Soldati, S., Scanziani, E. et al. Effects of IL-12 gene therapy on spontaneous transgenic and transplanted breast tumors. Breast Cancer Res Treat 110, 223–226 (2008). https://doi.org/10.1007/s10549-007-9713-6
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DOI: https://doi.org/10.1007/s10549-007-9713-6