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Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies

  • Epidemiology
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Abstract

To evaluate the relationship of genetic polymorphism in XRCC3 Thr241Met and the risk of breast cancer, a hospital-based case-control study was conducted in Korea. Histologically confirmed breast cancer cases (n = 574) and controls (n = 502) with no present or previous history of cancer were recruited from several teaching hospitals in Seoul during 1995–2001. Information on demographic characteristics and other information were collected by interviewed questionnaire. Genetic polymorphisms of XRCC3 Thr241Met (C > T) was determined by single base extention assay. The frequency of Thr/Thr, Thr/Met, and Met/Met genotype were 89.4, 10.4, 0.2% in cases and 92.3, 7.7, 0.0% in controls, respectively. Genotype distribution in controls fit well to the Hardy–Weinberg equilibrium (P = 0.74). XRCC3 codon 241 Thr/Met or Met/Met genotype moderately increased the risk of breast cancer (OR = 1.4, 95% CI: 0.87–2.33), but not significant in this study. In the results of meta-analysis using twelve reports, however, Thr/Met or Met/Met genotype increased the risk of breast cancer (OR = 1.08, 95%CI: 1.00–1.17). In conclusion, although the genetic polymorphism of XRCC3 Thr241Met was unlikely to have a substantial overall association in Korean women, the meta-analysis of studies, including ours, provided that Thr/Met and Met/Met was weakly increased the risk of breast cancer compare to Thr/Thr genotype.

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Acknowledgments

This study was supported by a grant from the National R&D Program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620410–1).

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Authors and Affiliations

  1. Department of Preventive Medicine, Cancer Research Institute, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul, 110-799, South Korea

    Sang-Ah Lee, Sue Kyung Park, Keun-Young Yoo & Daehee Kang

  2. Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, 20892, USA

    Kyoung-Mu Lee

  3. Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY, 14263, USA

    Ji-Yeob Choi

  4. Pan Genomics Co., Ltd., Seoul, South Korea

    Bongcheol Kim & Jinwu Nam

  5. Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea

    Dong-Young Noh

  6. Department of Surgery, Asan Medical Center, Ulsan University College of Medicine, Seoul, South Korea

    Sei-Hyun Ahn

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  1. Sang-Ah Lee
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  2. Kyoung-Mu Lee
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Correspondence to Daehee Kang.

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Lee, SA., Lee, KM., Park, S.K. et al. Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies. Breast Cancer Res Treat 103, 71–76 (2007). https://doi.org/10.1007/s10549-006-9348-z

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  • DOI: https://doi.org/10.1007/s10549-006-9348-z

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