Increased Functional MEG Connectivity as a Hallmark of MRI-Negative Focal and Generalized Epilepsy

Li Hegner, Yiwen; Marquetand, Justus; Elshahabi, Adham; Klamer, Silke; Lerche, Holger; Braun, Christoph; Focke, Niels K.

doi:10.1007/s10548-018-0649-4

Original Paper
Published: 15 May 2018

Increased Functional MEG Connectivity as a Hallmark of MRI-Negative Focal and Generalized Epilepsy

Yiwen Li Hegner ORCID: orcid.org/0000-0001-9960-6958¹,
Justus Marquetand¹,
Adham Elshahabi^1,2,
Silke Klamer¹,
Holger Lerche^1,2,
Christoph Braun^2,3,4 &
Niels K. Focke^1,2,5

Brain Topography volume 31, pages 863–874 (2018)Cite this article

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Abstract

Epilepsy is one of the most prevalent neurological diseases with a high morbidity. Accumulating evidence has shown that epilepsy is an archetypical neural network disorder. Here we developed a non-invasive cortical functional connectivity analysis based on magnetoencephalography (MEG) to assess commonalities and differences in the network phenotype in different epilepsy syndromes (non-lesional/cryptogenic focal and idiopathic/genetic generalized epilepsy). Thirty-seven epilepsy patients with normal structural brain anatomy underwent a 30-min resting state MEG measurement with eyes closed. We only analyzed interictal epochs without epileptiform discharges. The imaginary part of coherency was calculated as an indicator of cortical functional connectivity in five classical frequency bands. This connectivity measure was computed between all sources on individually reconstructed cortical surfaces that were surface-aligned to a common template. In comparison to healthy controls, both focal and generalized epilepsy patients showed widespread increased functional connectivity in several frequency bands, demonstrating the potential of elevated functional connectivity as a common pathophysiological hallmark in different epilepsy types. Furthermore, the comparison between focal and generalized epilepsies revealed increased network connectivity in bilateral mesio-frontal and motor regions specifically for the generalized epilepsy patients. Our study indicated that the surface-based normalization of MEG sources of individual brains enables the comparison of imaging findings across subjects and groups on a united platform, which leads to a straightforward and effective disclosure of pathological network characteristics in epilepsy. This approach may allow for the definition of more specific markers of different epilepsy syndromes, and increased MEG-based resting-state functional connectivity seems to be a common feature in MRI-negative epilepsy syndromes.

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Acknowledgements

Author A.E. was funded by the Werner Reichardt Center for Integrative Neuroscience, Pool Project Number (2014-02), University of Tuebingen. Author N.K.F. was supported by DFG Grant FO-750 5/1. Part of this work was performed on the computational resource bwUniCluster funded by the Ministry of Science, Research and the Arts Baden-Württemberg and the Universities of the State of Baden-Württemberg, Germany, within the framework program bwHPC.

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Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Hope-Seyler-Straße 3, 72076, Tübingen, Germany
Yiwen Li Hegner, Justus Marquetand, Adham Elshahabi, Silke Klamer, Holger Lerche & Niels K. Focke
Werner Reichardt Centre for Integrative Neuroscience, Tübingen, Germany
Adham Elshahabi, Holger Lerche, Christoph Braun & Niels K. Focke
MEG Center, University of Tübingen, Tübingen, Germany
Christoph Braun
CIMeC, Center for Mind/Brain Sciences, University of Trento, Trento, Italy
Christoph Braun
Clinical Neurophysiology, University of Göttingen, Göttingen, Germany
Niels K. Focke

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Yiwen Li Hegner
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Justus Marquetand
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Adham Elshahabi
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Silke Klamer
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Holger Lerche
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Christoph Braun
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Niels K. Focke
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Correspondence to Yiwen Li Hegner.

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N.K.F. has received speaker honoraria from Eisai, UCB and Bial and served in advisory boards for Eisai and Bial, none of which were directly related to the present work. The other authors have no conflict of interest to disclose.

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Li Hegner, Y., Marquetand, J., Elshahabi, A. et al. Increased Functional MEG Connectivity as a Hallmark of MRI-Negative Focal and Generalized Epilepsy. Brain Topogr 31, 863–874 (2018). https://doi.org/10.1007/s10548-018-0649-4

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Received: 09 January 2018
Accepted: 08 May 2018
Published: 15 May 2018
Issue Date: September 2018
DOI: https://doi.org/10.1007/s10548-018-0649-4

Keywords

Imaginary part of coherency
Graph theory
Resting state
Interictal
Whole brain