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Fabrication of separable microneedles with phase change coating for NIR-triggered transdermal delivery of metformin on diabetic rats

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Abstract

To enhance the compliance of drug delivery for patients, the novel near-infrared (NIR) light-triggered and separable microneedles (MNs) have been developed in this work. Firstly, prussian blue nanoparticles (PB NPs) as the photo-thermal conversion factor and metformin as the hypoglycemic drug were embedded into the separable arrowheads, which consisted by poly (vinyl alcohol) and sucrose (PVA/Suc). The arrowheads of MNs were located on soluble solids supporting substrates that produced by poly(vinyl pyrrolidone) (PVP). Lauric acid (LA) as the phase transition coating covered on the surface of the MNs due to its lower phase transition temperature (~44 °C). Then, the separable arrowheads could be left into the skin because of the absorbing the interstitial fluid (IF) by the solid supporting substrates. With the irradiation of NIR light, LA could be melted due to the role of PB NPs in photo-thermal conversion, thus releasing the metformin from arrowheads. Compared with the traditional subcutaneous injections, the hypoglycemic effect was evaluated by the drug-release behaviors induced by NIR in vivo. The results showed that metformin could be allowed to on-demand release under the NIR irradiation. And the as-obtained MNs exhibited a good hypoglycemic effect, hypotoxicity and low inflammation reaction compared with those of traditional subcutaneous injections. The results indicate that the fabricated MNs have the potential treatment for diabetes due to their safety, convenience and painlessness.

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Funding

This work was financially supported by the National Natural Science Foundation of China (51873194, 51373155), Natural Science Foundation of Zhejiang Province (LY18E030006) and “521 Talents Training Plan” in Zhejiang Sci-Tech University (ZSTU). We also gratefully acknowledge Hua-An Biotechnology Co., Ltd. (Hangzhou, China) for histological experiments.

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Authors and Affiliations

  1. Department of Polymer Materials, College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, Zhejiang, China

    Tianqi Liu, Guohua Jiang, Gao Song, Jiangying Zhu & Yuhui Yang

  2. National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou, 310018, China

    Tianqi Liu, Guohua Jiang, Gao Song, Jiangying Zhu & Yuhui Yang

  3. Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou, 310018, Zhejiang, China

    Tianqi Liu, Guohua Jiang, Gao Song, Jiangying Zhu & Yuhui Yang

  4. Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, Zhejiang, China

    Guohua Jiang & Yuhui Yang

  5. Institute of Smart Fiber Materials, Zhejiang Sci-Tech University, Hangzhou, 310018, Zhejiang, China

    Guohua Jiang & Yuhui Yang

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  1. Tianqi Liu
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Correspondence to Guohua Jiang.

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Liu, T., Jiang, G., Song, G. et al. Fabrication of separable microneedles with phase change coating for NIR-triggered transdermal delivery of metformin on diabetic rats. Biomed Microdevices 22, 12 (2020). https://doi.org/10.1007/s10544-019-0468-8

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