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Electrical sensing of DNA-hybridization using two-port network based on suspended carbon nanotube membrane

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Abstract

An approach was presented for electrical sensing of deoxyribonucleic acid (DNA)-hybridization in solution using a two-port network based on single-walled suspended carbon nanotube (SWCNT) membrane. A single stranded probe DNA (5′-NH2-(CH2)6-CGC CGA TTG GAC AAA ACT TAA A-3′) was immobilized on the SWCNT membrane. A solution with the complementary single stranded DNA (D′FITC: 5′-FITC-T TTA AGT TTT GTC CAA TCG GCG-3′) in various concentrations was then dropped on the membrane. The two-port network composed of the suspended SWCNT membrane and its underneath gate were characterized by coupling with a vector network analyzer. The resonance frequency of transmission coefficient S21 was observed to be around 10 MHz. The resonance frequency shifts with DNA-hybridization, and the sensing limit was approximately 50 nM. The advantages of this approach include low-noise frequency output, solution based real time detection and capable of on-chip integration, etc.

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Acknowledgments

This work was supported by the NSFC under project no. 61071010.

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Authors and Affiliations

  1. Pen-Tung Sah Institute of Micro-Nano Science & Technology, Xiamen University, Xiamen, 361005, People’s Republic of China

    Tun Wang, Xing-Xing Feng, Hong Chen & Miao Lu

  2. Department of Physics, Xiamen University, Xiamen, 361005, China

    Ze-Zhi Zheng

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  1. Tun Wang
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  2. Ze-Zhi Zheng
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  3. Xing-Xing Feng
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  4. Hong Chen
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  5. Miao Lu
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Correspondence to Miao Lu.

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Wang, T., Zheng, ZZ., Feng, XX. et al. Electrical sensing of DNA-hybridization using two-port network based on suspended carbon nanotube membrane. Biomed Microdevices 17, 103 (2015). https://doi.org/10.1007/s10544-015-0009-z

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  • DOI: https://doi.org/10.1007/s10544-015-0009-z

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