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Fabrication and testing of high-performance detection sensor for capillary electrophoresis microchips

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Abstract

This study presents a new approach for high-performance detection sensors for MEMS-based capillary electrophoresis chips to substitute laser induced fluorescence (LIF) detection systems. The developed sensors easily integrate with well-known microfabrication techniques for glass-based microfluidic devices. Three-dimensional gold electrodes are structured in enveloping side channels by sputtering and patterned using a standard “lift-off” process. The variations in the capacitance between the electrodes in the side channels are measured as different samples and ions pass through the detection region of the capillary electrophoresis separation channel. Samples of beer, white wine and milk are each mixed in different buffer solutions, then successfully separated and detected using the developed device. The proposed high-performance detection sensors have microscale dimensions and provide a critical step towards the realization of the lab-on-a-chip concept.

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Acknowledgments

The current authors gratefully acknowledge the financial support provided to this project by the National Science Council of Taiwan under Grant Number NSC-95-2314-B-020-001-MY2 and NSC-95-2221-E-212-058.

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Authors and Affiliations

  1. Department of Materials Engineering, National Pingtung University of Science and Technology, 912, Pingtung, Taiwan

    Lung-Ming Fu

  2. Department of Mechanical and Automation Engineering, Da-Yeh University, 515, Changhua, Taiwan

    Chia-Yen Lee

  3. Department of Veterinary Medicine, National Pingtung University of Science and Technology, 912, Pingtung, Taiwan

    Ming-Huei Liao

  4. Department of Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, 804, Kaohsiung, Taiwan

    Che-Hsin Lin

Authors
  1. Lung-Ming Fu
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  2. Chia-Yen Lee
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  3. Ming-Huei Liao
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  4. Che-Hsin Lin
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Corresponding author

Correspondence to Chia-Yen Lee.

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Fu, LM., Lee, CY., Liao, MH. et al. Fabrication and testing of high-performance detection sensor for capillary electrophoresis microchips. Biomed Microdevices 10, 73–80 (2008). https://doi.org/10.1007/s10544-007-9111-1

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  • DOI: https://doi.org/10.1007/s10544-007-9111-1

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