Abstract
Gastric cancer is the third leading cause of cancer death, and gastric precancerous lesions (GPLs) are an important stage in the transformation of normal gastric mucosa to gastric cancer. Matched for age and sex, a total of 316 subjects were eventually included from our prospective observation population (including 1007 patients with GPLs and 762 normal controls), and a questionnaire survey was conducted. In total, 10 plasma elements (iron, copper, zinc, selenium, rubidium, strontium, titanium, aluminum, vanadium and arsenic) were measured by applying inductively coupled plasma‒mass spectrometry (ICP‒MS). A multivariate conditional logistic regression model and Bayesian kernel logistic regression model (BKMR) were used to analyze the association between plasma element concentrations and GPLs. In the multimetal model, plasma titanium concentrations were significantly and positively associated with the prevalence of GPLs, with a fourth-quartile OR of 11.56 ([95% CI]: [2.78–48.13]). Plasma selenium and copper were negatively correlated with GPLs, with the highest quartiles of selenium and copper having an OR of 0.03 ([95% CI]: [0.01–0.15]; P < 0.001) and 0.24 ([95% CI]: [0.07–0.82]), respectively. In the BKMR model, there was a significant negative combined correlation of five metals on GPLs: iron, copper, zinc, selenium, and titanium. The results of this study showed that plasma concentrations of selenium and copper were negatively correlated with GPLs, while plasma concentrations of titanium were positively correlated with GPLs, and the combined action of the five elements was negatively correlated with GPLs.
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Data availability
The data generated during and analyzed during the current study are not publicly available due to the nature of this research, participants of this study did not agree for the data to be shared publicly, so supporting data is not available, but are available from the corresponding author on reasonable request.
Abbreviations
- GPLs:
-
Gastric precancerous lesions
- BMI:
-
Body mass index
- HP:
-
Helicobacter pylori
- Fe:
-
Iron
- Cu:
-
Copper
- Zn:
-
Zinc
- Se:
-
Selenium
- Rb:
-
Rubidium
- Sr:
-
Strontium
- Ti:
-
Titanium
- Al:
-
Aluminum
- V:
-
Vanadium
- As:
-
Arsenic
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Acknowledgements
We appreciate all patients and doctors participated in the present study. We also appreciate the funding aforementioned supported for this study. The funding agencies had no role in the design and conduct of the study; collection, management, analysis, or interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication. And we also appreciate the advice from Dr. Gengsheng He, School of Public Health, Fudan University.
Funding
This study was supported from the National Natural Science Foundation of China (No. 81973049), Anhui Province Peak Discipline Construction Plan (Grant No. 0301001861), and Basic and Clinical Cooperative Research Promotion Program of Anhui Medical University (No. 2020xkjT031).
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Study concept and design: YZ, DZ, AH and QZ; data acquisition: TW, FX, YL, XZ, WC, DZ, YZ, YL, LW, MW, XL, MZ, TX, SQ, MT, WY; data analysis: TW, FX; data interpretation: TW, FX; article drafting: TW, FX; manuscript review and editing: QZ.
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Wang, T., Xu, F., Lin, X. et al. Co-exposure to iron, copper, zinc, selenium and titanium is associated with the prevention of gastric precancerous lesions. Biometals 36, 1141–1156 (2023). https://doi.org/10.1007/s10534-023-00509-6
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DOI: https://doi.org/10.1007/s10534-023-00509-6