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Iron trafficking system in Helicobacter pylori

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Abstract

Helicobacter pylori infections are closely associated with peptic ulcers, gastric malignancy and iron deficiency anemia. Iron is essential for almost all living organisms and the investigation of iron uptake and trafficking system is thus important to understand the pathological roles of H. pylori. Up to now, the iron trafficking system of H. pylori is not yet fully clear and merits further efforts in this regards. The available information about iron uptake and regulation has been discussed in this concise review, such as FeoB in ferrous transportation, FrpB2 in hemoglobin uptake, HugZ in heme processing, virulence factors (VacA and CagA) in transferrin utilization, Pfr and NapA in iron storage and Fur in iron regulation. The identified iron trafficking system will help us to understand the pathological roles of H. pylori in the various gastric diseases and iron deficiency anemia and stimulates further development of effective anti-bacterial drugs.

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Abbreviations

ABC:

ATP-binding protein cassette

Dps:

DNA-protecting proteins

EMSA:

electrophoretic mobility shift assay

Fur:

ferric uptake regulator

H. pylori :

Helicobacter pylori

IDA:

iron deficiency anemia

sRNA:

Small regulatory RNA

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Acknowledgments

Dr. Rory Watt from HKU is acknowledged for the help in the preparation of this paper. This work was partially supported by National Natural Science Foundation of China (20801061 and 31000373), Guangdong Natural Science Foundation (8451027501001233) and the Fundamental Research Funds for the Central Universities (10lgpy19 and 21611201).

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  1. Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol and The Laboratory of Integrative Biology, College of Life Sciences, Sun Yat-Sen University, Guangzhou, 510275, China

    Ruiguang Ge

  2. Institute of Life and Health Engineering and National Engineering Research Center for Genetic Medicine, Jinan University, Guangzhou, 510632, China

    Xuesong Sun

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Correspondence to Ruiguang Ge.

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Ge, R., Sun, X. Iron trafficking system in Helicobacter pylori . Biometals 25, 247–258 (2012). https://doi.org/10.1007/s10534-011-9512-8

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