Biotechnology Letters

, Volume 37, Issue 5, pp 955–972 | Cite as

Microbial production of lactic acid

Review

Abstract

Lactic acid is an important commodity chemical having a wide range of applications. Microbial production effectively competes with chemical synthesis methods because biochemical synthesis permits the generation of either one of the two enantiomers with high optical purity at high yield and titer, a result which is particularly beneficial for the production of poly(lactic acid) polymers having specific properties. The commercial viability of microbial lactic acid production relies on utilization of inexpensive carbon substrates derived from agricultural or waste resources. Therefore, optimal lactic acid formation requires an understanding and engineering of both the competing pathways involved in carbohydrate metabolism, as well as pathways leading to potential by-products which both affect product yield. Recent research leverages those biochemical pathways, while researchers also continue to seek strains with improved tolerance and ability to perform under desirable industrial conditions, for example, of pH and temperature.

Keywords

Lactate Lignocellulosic hydrolysate pH tolerance Phosphoketolase Thermotolerance 

References

  1. Adachi E, Torigoe M, Sugiyama M, Nikawa JI, Shimizu K (1998) Modification of metabolic pathways of Saccharomyces cerevisiae by the expression of lactate dehydrogenase and deletion of pyruvate decarboxylase genes for the lactic acid fermentation at low pH value. J Ferment Bioeng 86:284–289Google Scholar
  2. Adsul MG, Varma AJ, Gokhale DV (2006) Lactic acid production from waste sugarcane bagasse derived cellulose. Green Chem 9:58–62Google Scholar
  3. Adsul MG, Khire J, Bastawde K, Gokhale D (2007) Production of lactic acid from cellobiose and cellotriose by Lactobacillus delbrueckii mutant Uc-3. Appl Environ Microbiol 73:5055–5057PubMedCentralPubMedGoogle Scholar
  4. Al-Mahin A, Sugimoto S, Higashi C, Matsumoto S, Sonomoto K (2010) Improvement of multiple-stress tolerance and lactic acid production in Lactococcus lactis NZ9000 under conditions of thermal stress by heterologous expression of Escherichia coli dnaK. Appl Environ Microbiol 76:4277–4285Google Scholar
  5. Bai DM, Li SZ, Liu ZL, Cui ZF (2008) Enhanced L-(+)-lactic acid production by an adapted strain of Rhizopus oryzae using corncob hydrolysate. Appl Biochem Biotechnol 144:79–85PubMedGoogle Scholar
  6. Bischoff KM, Liu S, Hughes SR, Rich JO (2010) Fermentation of corn fiber hydrolysate to lactic acid by the moderate thermophilic Bacillus coagulans. Biotechnol Lett 32:823–828PubMedGoogle Scholar
  7. Blomqvist J (2001) RIS Metropolis Monte Carlo studies of poly(lactic), poly(L, D-lactic) and polyglycolic acids. Polymer 42:3515–3521Google Scholar
  8. Branduardi P, Sauer M, De Gioia L, Zamella G, Valli M, Mattanovich D, Porro D (2006) Lactate production yield from engineered yeasts is dependent from the host background, the lactate dehydrogenase source and the lactate export. Microb Cell Fact 5:4PubMedCentralPubMedGoogle Scholar
  9. Carlson TL, Peters EM, Jr. (2002) Low pH lactic acid fermentation. US Patent 6,475,759, 5 Nov 2002Google Scholar
  10. Castro R, Neves AR, Fonseca LL, Pool WA, Kok J, Kuipers OP, Santos H (2009) Characterization of the individual glucose uptake systems of Lactococcus lactis: mannose-PTS, cellobiose-PTS and the novel GlcU permease. Mol Microbiol 71:795–806PubMedGoogle Scholar
  11. Chaillou S, Bor YC, Batt CA, Postma PW, Pouwels PH (1998) Molecular cloning and functional expression in Lactobacillus plantarum 80 of xylT, encoding the D-xylose-H + symporter of Lactobacillus brevis. Appl Environ Microbiol 64:4720–4728PubMedCentralPubMedGoogle Scholar
  12. Chaillou S, Pouwels PH, Postma PW (1999) Transport of D-xylose in Lactobacillus pentosus, Lactobacillus casei, and Lactobacillus plantarum: evidence of a mechanism of facilitated diffusion via the phosphoenolpyruvate:mannose phosphotransferase system. J Bacteriol 181:4768–4773PubMedCentralPubMedGoogle Scholar
  13. Chang DE, Jung HC, Rhee JS, Pan JG (1999) Homofermentative production of D- or L-lactate in metabolically engineered Escherichia coli RR1. Appl Environ Microbiol 65:1384–1389PubMedCentralPubMedGoogle Scholar
  14. Chen XZ, Tian KM, Niu DD, Shen W, Algasan G, Singh S, Wang ZX (2014) Efficient bioconversion of crude glycerol from biodiesel to optically pure D-lactate by metabolically engineered Escherichia coli. Green Chem 16:342–350Google Scholar
  15. Cui F, Li Y, Wan C (2011) Lactic acid production from corn stover using mixed cultures of Lactobacillus rhamnosus and Lactobacillus brevis. Biores Technol 102:1831–1836Google Scholar
  16. Datta R, Henry M (2006) Lactic acid: recent advances in products, process, and technologies: a review. J Chem Technol Biotechnol 81:1119–1129Google Scholar
  17. De Angelis M, Bini L, Pallini V, Cocconcelli PS, Gobbetti M (2001) The acid-stress response in Lactobacillus sanfranciscensis CB1. Microbiology 147:1863–1873PubMedGoogle Scholar
  18. de Jong SJ, van Eerdenbrugh B, van Nostrum CF, Kettenes-van de Bosch JJ, Hennink WE (2001) Physically crosslinked dextran hydrogels stereocomplex formation of lactic acid oligomers: degradation and protein release behavior. J Contr Rel 71:261–275Google Scholar
  19. de Kok S, Nijkamp JF, Oud B, Roque FC, de Ridder D, Daran JM, Pronk JT, van Maris AJA (2012) Laboratory evolution of new lactate transporter gene in a jen1Δ mutant of Saccharomyces cerevisiae and their identification as ADY2 alleles by whole-genome resequencing and transcriptome analysis. FEMS Yeast Res 12:359–374Google Scholar
  20. Dequin S, Barre P (1994) Mixed lactic acid-alcoholic fermentation by Saccharomyces cerevisiae expressing the Lactobacillus casei L(+)-LDH. Nature Biotechnol 12:173–177Google Scholar
  21. Dien BS, Nichols NN, Bothast RJ (2001) Recombinant Escherichia coli engineered for production of L-lactic acid from hexose and pentose sugars. J Ind Microbiol Biotechnol 27:259–264PubMedGoogle Scholar
  22. Dien BS, Nichols NN, Bothast RJ (2002) Fermentation of sugar mixtures using Escherichia coli catabolite repression mutants engineered for production of L-lactic acid. J Ind Microbiol Biotechnol 29:221–227PubMedGoogle Scholar
  23. Drumright RE, Gruber PR, Henton DE (2000) Polylactic acid technology. Adv Mater 12:1841–1846Google Scholar
  24. Eddington JM, Johnson KB, Liaw HJ, Rowe M, Yang Y (2007) Lactobacillus strains and use thereof in fermentation for L-lactic acid production. US Patent 7,300,787, 27 Nov 2007Google Scholar
  25. Eiteman MA, Lee SA, Altman E (2008) A co-fermentation strategy to consume sugar mixtures effectively. J Biol Eng 2:3PubMedCentralPubMedGoogle Scholar
  26. Eiteman MA, Lee SA, Altman R, Altman E (2009) A substrate-selective co-fermentation strategy with Escherichia coli produces lactate by simultaneously consuming xylose and glucose. Biotechnol Bioeng 102:822–827PubMedGoogle Scholar
  27. Feng X, Ding Y, Xian M, Xu X, Zhang R, Zhao G (2014) Production of optically pure D-lactate from glycerol by engineered Klebsiella pneumoniae strains. Biores Technol 172:269–275Google Scholar
  28. Gao C, Ma C, Xu P (2011) Biotechnological routes based on lactic acid production from biomass. Biotechnol Adv 29:930–939PubMedGoogle Scholar
  29. Ge XY, Qian H, Zhang WG (2009) Improvement of L-lactic acid production from Jerusalem artichoke tubers by mixed culture of Aspergillus niger and Lactobacillus sp. Biores Technol 100:1872–1974Google Scholar
  30. Ge XY, Yuan J, Qin H, Zhang WG (2011) Improvement of L-lactic acid production by osmotic-tolerant mutant of Lactobacillus casei at high temperature. Appl Microbiol Biotechnol 89:73–78PubMedGoogle Scholar
  31. Gruber PR, Hall ES, Kolstad JJ, Iwen ML, Benson RD, Borchadt RL (1992) Continuous process for manufacture of lactide polymers with controlled optical purity. US Patent 5,142,023, 25 Aug 1992Google Scholar
  32. Gruber PR, Kolstad JJ, Ryan CM, Hall ES, Eichen Conn RS (1996) Meta-stable amorphsus lactide polymer film and process for manufacturing thereof. US Patent 5,484,881, 16 Jan 1996Google Scholar
  33. Guo W, Jia W, Chen S (2010a) Performances of Lactobacillus brevis for producing lactic acid from hydrolysate of lignocellulosics. Appl Biochem Biotechnol 161:124–136PubMedGoogle Scholar
  34. Guo Y, Yan Q, Jiang Z, Teng C, Wang X (2010b) Efficient production of lactic acid from sucrose and corncob hydrolysate by a newly isolated Rhizopus oryzae GY18. J Ind Microbiol Biotechnol 37:1137–1143PubMedGoogle Scholar
  35. Hause B, Rajgarhia V, Suominen P (2009) Methods and materials for the production of L-lactic acid in yeast. US Patent 7,534,597, 19 May 2009Google Scholar
  36. Heriban V, Šterdík E, Zalibera L, Matuš P (1993) Process and metabolic characteristics of Bacillus coagulans as a lactic acid producer. Lett Appl Microbiol 16:243–246Google Scholar
  37. Hofvendahl K, Hahn-Hägerdal B (2000) Factors affecting the fermentative lactic acid production from renewable resources. Enz Microb Technol 26:87–107Google Scholar
  38. Ikushima S, Fujii T, Kobayashi O, Yoshida S, Yoshida A (2009) Genetic engineering of Candida utilis yeast for efficient production of L-lactic acid. Biosci Biotechnol Biochem 73:1818–1824PubMedGoogle Scholar
  39. Ilmén M, Koivuranta K, Ruohonen L, Suominen P, Penttilä M (2007) Efficient production of l-lactic acid from xylose by Pichia stipitis. Appl Environ Microbiol 73:117–123PubMedCentralPubMedGoogle Scholar
  40. Ishida N, Suzuki T, Tokuhiro K, Nagamori E, Onishi T, Saitoh S, Kitamoto K, Takahashi H (2006a) D-lactic acid production by metabolically engineered Saccharomyces cerevisiae. J Biosci Bioeng 101:172–177PubMedGoogle Scholar
  41. Ishida N, Saitoh S, Onishi T, Tokuhiro K, Nagamore E, Kitamoto K, Takahashi H (2006b) The effect of pyruvate decarboxylase gene knockout in Saccharomyces cerevisiae on L-lactic acid production. Biosci Biotechnol Biochem 70:1148–1153PubMedGoogle Scholar
  42. John RP, Nampoothiri KM (2008) Strain improvement of Lactobacillus delbrueckii using nitrous acid mutation for L-lactic acid production. World J Microbiol Biotechnol 24:3105–3109Google Scholar
  43. John RP, Anisha GS, Nampoothiri KM, Pandey A (2009) Direct lactic acid fermentation: focus on simultaneous saccharification and lactic acid production. Biotechnol Adv 27:145–152PubMedGoogle Scholar
  44. Joshi DS, Singhvi MS, Khire JM, Gokhale DV (2010) Strain improvement of Lactobacillus lactis for D-lactic acid production. Biotechnol Lett 32:517–520PubMedGoogle Scholar
  45. Kato H, Shiwa Y, Oshima K, Machii M, Araya-Kojima T, Zendo Y, Shimizu-Kadota M, Hattori M, Sonomoto K, Yoshikawa H (2012) Complete genome sequence of Lactococcus lactis IO-1, a lactic acid bacterium that utilizes xylose and produces high levels of L-lactic acid. J Bacteriol 194:2102–2103PubMedCentralPubMedGoogle Scholar
  46. Kharas GB, Sanchez-Riera F, Severson DK (1994) Polymers of lactic acid. In: Mobley DP (ed) Plastics from microbes: microbial synthesis of polymers and polymer precursors. Hanser Publishers, Munich, pp 93–137Google Scholar
  47. Levering J, Musters MWJM, Bekker M, Bellomo D, Fiedler T, de Vos WM, Hugenholtz J, Kreikemeyer B, Kummer U, Teusing B (2012) Role of phosphate in the central metabolism of two lactic acid bacteria—a comparative systems biology approach. FEBS J 279:1274–1290PubMedGoogle Scholar
  48. Liu Y, Gao W, Zhao X, Wang J, Garza E, Manow R, Zhou S (2014) Pilot scale demonstration of D-lactic acid fermentation facilitated by Ca(OH)2 using a metabolically engineered Escherichia coli. Biores Technol 169:559–565Google Scholar
  49. Lunt J (1998) Large-scale production, properties and commercial applications of polylactic acid polymers. Polym Degrad Stabil 59:145–152Google Scholar
  50. Maas RHW, Springer J, Eggink G, Weusthuis RA (2008) Xylose metabolism in the fungus Rhizopus oryzae: effect of growth and respiration on L(+)-lactic acid production. J Ind Microbiol Biotechnol 35:569–578PubMedCentralPubMedGoogle Scholar
  51. Marques S, Santos JAL, Girio FM, Roseiro JC (2008) Lactic acid production from recycled paper sludge by simultaneous saccharification and fermentation. Biochem Eng J 41:210–216Google Scholar
  52. Mazumdar S, Clomburg JM, Gonzalez R (2010) Escherichia coli strains engineered for homofermentative production of d-lactic acid from glycerol. Appl Environ Microbiol 76:4327–4336PubMedCentralPubMedGoogle Scholar
  53. Mazumdar S, Blankschien M, Clomburg JM, Gonzalez R (2013) Efficient synthesis of L-lactic acid from glycerol by metabolically engineered Escherichia coli. Microb Cell Fact 12:7PubMedCentralPubMedGoogle Scholar
  54. Michelson T, Kask K, Jõgi E, Talpsep E, Suitso I, Nurk A (2006) L(+)-Lactic acid producer Bacillus coagulans SIM-7 DSM 14043 and its comparison with Lactobacillus delbrueckii ssp. lactis DSM 20073. Enzyme Microb Technol 39:861–867Google Scholar
  55. Miller M, Suominen P, Aristidou A, Hause BM, van Hoek P, Dundon, CA (2012) Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreducatease cells. US Patent 8,137,953, 20 Mar 2012Google Scholar
  56. Mimitsuda T, Sawai K, Kobayashi K, Tsukada T, Takeuchi N, Yamada K, Ogino H, Yonehara T (2014) Production of D-lactic acid in a continuous membrane integrated fermentation reactor by genetically modified Saccharomyces cerevisiae: Enhancement in D-lactic acid carbon yield. J Biosci Bioeng (in press)Google Scholar
  57. Ohara H, Yahata M (1996) L-Lactic acid production by Bacillus sp. in anaerobic and aerobic culture. J Ferment Bioeng 81:272–274Google Scholar
  58. Okano K, Yoshida S, Tanaka T, Ogino C, Fukuda H, Kondo A (2009a) Homo-D-lactic acid fermentation from arabinose by redirection of the phosphoketolase pathway to the pentose phosphate pathway in L-lactate dehydrogenase gene-deficient Lactobacillus plantarum. Appl Environ Microbiol 75:5175–5178PubMedCentralPubMedGoogle Scholar
  59. Okano K, Yoshida S, Yamada R, Tanaka T, Ogino C, Fukuda H, Kondo A (2009b) Improved production of homo-D-lactic acid via xylose fermentation by introduction of xylose assimilation genes and redirection of the phosphoketolase pathway to the pentose phosphate pathway in L-lactate dehydrogenase gene-deficient Lactobacillus plantarum. Appl Environ Microbiol 75:7858–7861PubMedCentralPubMedGoogle Scholar
  60. Okano K, Tanaka T, Ogino C, Fukuda H, Kondo A (2010) Biotechnological production of enantiomeric pure lactic acid from renewable resources: recent achievements, perspectives, and limits. Appl Microbiol Biotechnol 85:413–423PubMedGoogle Scholar
  61. Okino S, Suda M, Fujijura K, Inui M, Yukawa H (2008) Production of D-lactic acid by Corynebacterium glutamicum under oxygen deprivation. Appl Microbiol Biotechnol 78:449–454PubMedGoogle Scholar
  62. Osawa F, Fujii T, Nishida T, Tada N, Ohnishi T, Komeda T, Yoshida S (2009) Efficient production of L-lactic acid by Crabtree-negative yeast Candida boidinii. Yeast 26:285–296Google Scholar
  63. Otto R (2012) Method for the production of lactic acid or a salt thereof by simultaneous saccharification and fermentation of starch. US Patent 8,119,376, 21 Feb 2012Google Scholar
  64. Ou MS, Ingram LO, Shanmugam KT (2011) L(+)-lactic acid production from non-food carbohydrates by thermotolerant Bacillus coagulans. J Ind Microbiol Biotechnol 38:599–605PubMedGoogle Scholar
  65. Ouyang J, Cai C, Chen H, Jiang T, Zheng Z (2012) Efficient non-sterilized fermentation of biomass-derived xylose to lactic acid by a thermotolerant Bacillus coagulans NL01. Appl Biochem Biotechnol 168:2387–2397PubMedGoogle Scholar
  66. Pacheco A, Talaia G, Sá-Pessoa J, Bessa D, Gonçalves MJ, Moreira R, Paiva S, Casal M, Queirós O (2012) Lactic acid production in Saccharomyces cerevisiae is modulated by expression of the monocarboxylate transporters Jen1 and Ady2. FEMS Yeast Res 12:375–381PubMedGoogle Scholar
  67. Paiva S, Devaux F, Barbosa S, Jacq C, Casal M (2004) Ady2p is essential for the acetate permease activity in the yeast Saccharomyces cerevisiae. Yeast 21:201–210PubMedGoogle Scholar
  68. Patel M, Ou M, Ingram LO, Shanmugam KT (2004) Fermentation of sugar cane bagasse hemicellulose hydrolysate to L(+)-lactic acid by a thermotolerant acidophilic Bacillus sp. Biotechnol Lett 26:865–868PubMedGoogle Scholar
  69. Patel MA, Ou MS, Harbrucker R, Aldrich HC, Buszko ML, Ingram LO, Shanmugam KT (2006) Isolation and characterization of acid-tolerant, thermophilic bacteria for effective fermentation of biomass-derived sugars to lactic acid. Appl Environ Microbiol 72:3228–3235PubMedCentralPubMedGoogle Scholar
  70. Payot T, Chemaly Z, Fick M (1999) Lactic acid production by Bacillus coagulans—kinetic studies and optimization of culture medium for batch and continuous fermentations. Enz Microb Technol 24:191–199Google Scholar
  71. Porro D, Brambilla L, Ranzi BM, Martegani E, Alberghina L (1995) Development of metabolically engineered Saccharomyces cerevisiae cells for the production of lactic acid. Biotechnol Prog 11:294–298PubMedGoogle Scholar
  72. Porro D, Bianchi M, Ranzi BM, Frontali L, Vai M, Winkler AA, Alberghina L (2006) Processes for producing lactic acid using yeast transformed with a gene encoding lactate dehydrogenase. US Patent 7,049,108, 23 May 2006Google Scholar
  73. Posada JA, Cardona CA, Gonzalez R (2012) Analysis of the production process of optically pure D-lactic acid from raw glycerol using engineered Escherichia coli strains. Appl Biochem Biotechnol 166:680–699PubMedGoogle Scholar
  74. Prior BA, Kilian SG, du Preez JC (1989) Fermentation of D-xylose by the yeasts Candida shehatae and Pichia stipitis: prospects and Problems. Proc Biochem 24:21–32Google Scholar
  75. Pyle DJ, Garcia RA, Wen Z (2008) Producing docosahexaenoic acid (DHA)-rich algae from biodiesel-derived crude glycerol: effects of impurities on DHA production and algal biomass composition. J Agric Food Chem 56:3933–3939PubMedGoogle Scholar
  76. Qin J, Zhao B, Wang X, Wang L, Yu B, Ma Y, Ma C, Tang H, Sun J, Xu P (2009) Non-sterilizes fermentative production of polymer-grade L-lactic acid by a newly isolated thermophilic strain Bacillus sp. 2–6. PLoS ONE 4:e4359PubMedCentralPubMedGoogle Scholar
  77. Qin J, Wang X, Zheng Z, Ma C, Tang H, Xu P (2010) Production of L-lactic acid by a thermophilic Bacillus mutant using sodium hydroxide as neutralizing agent. Biores Technol 101:7570–7576Google Scholar
  78. Rallu F, Gruss A, Ehlich SD, Maguin E (2000) Acid- and multistress-resistant mutants of Lactococcus lactis: identification of intracellular stress signals. Mol Microbiol 35:517–528PubMedGoogle Scholar
  79. Rico J, Yebra MJ, Pérez-Martínez G, Deutscher J, Monedero V (2008) Analysis of ldh genes in Lactobacillus casei BL23: role on lactic acid production. J Ind Microbiol Biotechnol 35:579–586PubMedGoogle Scholar
  80. Rosenberg M, Rebroš M, Krištofíková L, Malátová K (2005) High temperature lactic acid production by Bacillus coagulans immobilized in LentiKats. Biotechnol Lett 27:1943–1947PubMedGoogle Scholar
  81. Rossi DM, de Souze EA, Ayub MAZ (2013) Biodiesel residual glycerol metabolism by Klebsiella pneumoniae: pool of metabolites under anaerobiosis and oxygen limitation as a function of feeding rates. Appl Biochem Biotechnol 169:1952–1964PubMedGoogle Scholar
  82. Sangproo M, Polyiam P, Jantama SS, Kanchanatawee S, Jantama K (2012) Metabolic engineering of Klebsiella oxytoca M5a1 to produce optically pure D-lactate in mineral salts medium. Biores Technol 119:191–198Google Scholar
  83. Sawaii H, Sawai K, Sonoki T, Hatahira S (2011) Yeast and method of production L-lactic acid. US Patent 8,071,357, 6 Dec 2011Google Scholar
  84. Shimizu-Kadota M, Kato H, Shiwa Y, Oshima K, Machii M, Araya-Kojima T, Zendo T, Hattori M, Sonomoto K, Yoshikawa H (2013) Genomic features of Lactococcus lactis IO-1, a lactic acid bacterium that utilizes xylose and produces high levels of L-lactic acid. Biosci Biotechnol Biochem 77:1804–1808PubMedGoogle Scholar
  85. Shinkawa S, Okano K, Yoshida S, Tanaka T, Ogino C, Fukuda H, Kondo A (2011) Improved homo L-lactic acid fermentation from xylose by abolishment of the phosphoketolase pathway and enhancement of the pentose phosphate pathway in genetically modified xylose-assimilating Lactococcus lactis. Appl Microbiol Biotechnol 91:1537–1544PubMedGoogle Scholar
  86. Singhvi M, Joshi D, Varma A, Gokhale D (2010) D-(-)-Lactic acid production from cellobiose and cellulose by Lactobacillus lactis mutant RM2-24. Green Chem 12:1106–1109Google Scholar
  87. Song Z, Sun Y, Wei B, Xiu Z (2013) Two-step salting-out extraction of 1,3-propanediol and lactic acid from the fermentation broth of Klebsiella pneumoniae on biodiesel-derived crude glycerol. Eng Life Sci 13:487–495Google Scholar
  88. Sumiya M, Davis EO, Packman LC, McDonald TP, Henderson PJ (1995) Molecular genetics of a receptor protein for D-xylose, encoded by the gene xylF, in Escherichia coli. Recept Chann 3:117–128Google Scholar
  89. Suominen P, Aristidou A, Pentilla M, Ilmen M, Ruohonen L, Koivuranta K, Roberg-Perez K (2012) Genetically modified yeast of the species Issatchenkia orientalis and closely relates species, and fermentation processes using same. US Patent 8,097,448, 17 Jan 2012Google Scholar
  90. Suzuki T, Sakamoto T, Sugiyama M, Ishida N, Kambe H, Obata S, Kaneko Y, Takahashi H, Harashima S (2013) Disruption of multiple genes whose deletion causes lactic acid resistance improves lactic acid resistance and productivity in Saccharomyces cerevisiae. J Biosci Bioeng 115:467–474PubMedGoogle Scholar
  91. Tamakawa H, Ikushima S, Yoshida S (2012) Efficient production of L-lactic acid from xylose by a recombinant Candida utilis strain. J Biosci Bioeng 113:73–75PubMedGoogle Scholar
  92. Tanaka K, Komiyama A, Sonomoto D, Ishizaki A, Hall SJ, Stanbury PF (2002) Two different pathways for D-xylose metabolism and the effect of xylose concentration on the yield coefficient of L-lactate in mixed-acid fermentation by the lactic acid bacterium Lactococcus lactis IO-1. Appl Microbiol Biotechnol 60:160–167PubMedGoogle Scholar
  93. Tanaka T, Hoshina M, Tanabe S, Sakai K, Ohtsubo S, Taniguchi M (2006) Production of D-lactic acid from defatted rice bran by simultaneous saccharification and fermentation. Biores Technol 97:211–217Google Scholar
  94. Tashiro Y, Kanedo W, Sun Y, Shibata K, Inokuma K, Zendo T, Sonomoto K (2011) Continuous D-lactic acid production by a novel thermotolerant Lactobacillus delbrueckii subsp. lactis QU 41. Appl Microbiol Biotechnol 89:1741–1750PubMedGoogle Scholar
  95. Tian K, Chen X, Shen W, Prior BA, Shi G, Singh S, Wang Z (2012) High-efficiency conversion of glycerol to D-lactic acid with metabolically engineered Escherichia coli Afri. J Biotechnol 11:4860–4867Google Scholar
  96. Tsuji H (2002) Autocatalytic hydrolysis of amorphous-made polylactides: effects of L-lactide content, tacticity, and enantiomeric polymer blending. Polymer 43:1789–1796Google Scholar
  97. Tsuji H, Fukui I (2003) Enhanced thermal stability of poly(lactide)s in the melt by enantiomeric polymer blending. Polymer 44:2891–2896Google Scholar
  98. Walton SL, Bischoff KM, van Heiningen ARP, van Walsum GP (2010) Production of lactic acid from hemicellulose extracts by Bacillus coagulans MXL-9. J Ind Microbiol Biotechnol 37:823–830PubMedGoogle Scholar
  99. Wang Y, Li Y, Pei X, Yu L, Feng Y (2007) Genome-shuffling improved acid tolerance and L-lactic acid volumetric productivity in Lactobacillus rhamnosus. J Biotechnol 129:510–515PubMedGoogle Scholar
  100. Wang P, Li J, Wang L, Tang ML, Yu ZL, Zheng ZM (2009) L(+)-Lactic acid production by co-fermentation of glucose and xylose with Rhizopus oryzae obtained by low-energy ion beam irradiation. J Ind Microbiol Biotechnol 36:1363–1368PubMedGoogle Scholar
  101. Wang L, Zhao B, Liu B, Yang C, Yu B, Li Q, Ma C, Xu P, Ma Y (2010a) Efficient production of L-lactic acid from cassava powder by Lactobacillus rhamnosus. Biores Technol 101:7895–7901Google Scholar
  102. Wang L, Zhao B, Liu B, Yu B, Ma C, Su F, Hua D, Li Q, Ma Y, Xu P (2010b) Efficient production of L-lactic acid from corncob molasses, a waste by-product in xylitol production, by a newly isolated xylose utilizing Bacillus strain. Biores Technol 101:7908–7915Google Scholar
  103. Wang Q, Ingram LO, Shanmugam KT (2011) Evolution of D-lactate dehydrogenase activity from glycerol dehydrogenase and its utility for D-lactate production from lignocellulose. Proc. Nat. Acad Sci USA 108:18920–18925PubMedCentralPubMedGoogle Scholar
  104. Wang Y, Tian T, Zhao J, Wang J, Yan T, Xu L, Liu Z, Garza E, Iverson A, Manow R, Finan C, Zhou S (2012) Homofermentative production of D-lactic acid from sucrose by a metabolically engineered Escherichia coli. Biotechnol Lett 34:2069–2075PubMedGoogle Scholar
  105. Wang Y, Li K, Huang F, Wang J, Zhao J, Zhao X, Garza E, Manow R, Grayburn S, Zhou S (2013) Engineering and adaptive evolution of Escherichia coli W for L-lactic acid fermentation from molasses and corn steep liquor without additional nutrients. Biores Technol 148:394–400Google Scholar
  106. Wehrenberg RH (1981) Lactic-acid polymers—strong, degradable thermoplastics—research at Battelle proves the value of limited-lifetime plastics made from renewable resources. Mater Eng 94:63–66Google Scholar
  107. Wu C, Zhang J, Chen W, Wang M, Du G, Chen J (2012) A combined physiological and proteomic approach to reveal lactic-acid-induced alterations in Lactobacillus casei Zhang and its mutant with enhanced lactic acid tolerance. Appl Microbiol Biotechnol 93:707–722PubMedGoogle Scholar
  108. Wu X, Altman R, Eiteman MA, Altman E (2013a) Effect of overexpressing nhaA and nhaR on sodium tolerance and lactate production in Escherichia coli. J Biol Eng 7:3PubMedCentralPubMedGoogle Scholar
  109. Wu C, Zhang J, Du G, Chen J (2013b) Heterologous expression Lactobacillus casei RecO improved the multiple-stress tolerance and lactic acid production in Lactococcus lactis NZ9000 during salt stress. Biores Technol 143:238–241Google Scholar
  110. Wu X, Altman R, Eiteman MA, Altman E (2014) Adaptation of Escherichia coli to elevated sodium concentrations increases cation tolerance and enables greater lactic acid production. Appl Environ Microbiol 80:2880–2888PubMedCentralPubMedGoogle Scholar
  111. Yáñez R, Moldes AB, Alonso JL, Parajó JC (2003) Production of D-lactic acid from cellulose by simultaneous saccharification and fermentation using Lactobacillus coryneformis subsp. torquens. Biotechnol Lett 25:1161–1164PubMedGoogle Scholar
  112. Yáñez R, Alonso JL, Parajó JC (2005) D-lactic acid production from waste cardboard. J Chem Technol Biotechnol 80:76–84Google Scholar
  113. Ye L, Zhao H, Li Z, Wu JC (2013a) Improved acid tolerance of Lactobacillus pentosus by error-prone whole genome amplification. Biores Technol 135:459–463Google Scholar
  114. Ye L, Zhou X, Bin Hudari MS, Li Z, Wu JC (2013b) Highly efficient production of L-lactic acid from xylose by newly isolated Bacillus coagulans C106. Biores Technol 132:38–44Google Scholar
  115. Yoshida S, Okano K, Tanaka T, Ogino C, Kondo A (2011) Homo-D-lactic acid production from mixed sugars using xylose-assimilating operon-integrated Lactobacillus plantarum. Appl Microbiol Biotechnol 92:67–76PubMedGoogle Scholar
  116. Yu L, Pei X, Lei T, Wang Y, Feng Y (2008) Genome shuffling enhanced L-lactic acid production by improving glucose tolerance of Lactobacillus rhamnosus. J Biotechnol 134:154–159PubMedGoogle Scholar
  117. Zhang ZY, Jin B, Kelly JM (2007) Production of lactic acid from renewable materials by Rhizopus fungi. Biochem Eng J 35:251–263Google Scholar
  118. Zhao B, Wang L, Ma C, Yang C, Xu P, Ma Y (2010) Repeated open fermentative production of optically pure L-lactic acid using a thermophilic Bacillus sp. strain. Biores Technol 101:6496–6498Google Scholar
  119. Zhao J, Xu L, Wang Y, Zhao X, Wang J, Garza E, Manow R, Zhou S (2013) Homofermentative production of optically pure L-lactic acid from xylose by genetically engineered Escherichia coli B. Microb Cell Fact 12:57PubMedCentralPubMedGoogle Scholar
  120. Zheng H, Gong J, Chen T, Chen X, Zhao X (2010) Strain improvement of Sporolactobacillus inulinus ATCC 15538 for acid tolerance and production of D-lactic acid by genome shuffling. Appl Microbiol Biotechnol 85:1541–1549PubMedGoogle Scholar
  121. Zheng Z, Sheng B, Ma C, Zhang H, Gao C, Su F, Xu P (2012) Relative catalytic efficiency of ldhL- and ldhD-encoded products is crucial for optical purity of lactic acid produced by Lactobacillus strains. Appl Environ Microbiol 78:3480–3483PubMedCentralPubMedGoogle Scholar
  122. Zhou Y, Dominguez JM, Cao N, Du J, Tsao GT (1999) Optimization of L-lactic acid production from glucose by Rhizopus oryzae ATCC 52311. Appl Biochem Biotechnol 77–79:401–407PubMedGoogle Scholar
  123. Zhou SD, Causey TB, Hasona A, Shanmugam KT, Ingram LO (2003) Production of optically pure D-lactic acid in mineral salts medium by metabolically engineered Escherichia coli W3110. Appl Environ Microbiol 69:399–407PubMedCentralPubMedGoogle Scholar
  124. Zhou SD, Shanmugam KT, Ingram LO (2004) Functional replacement of the Escherichia coli D-(-)lactate dehydrogenase gene (ldhA) with the L-(+)-lactate dehydrogenase gene (ldhL) from Pediococcus acidilactici. Appl Environ Microbiol 69:2237–2244Google Scholar
  125. Zhu Y, Eiteman MA, Dewitt K, Altman E (2007) Homolactate fermentation by metabolically engineered Escherichia coli strains. Appl Environ Microbiol 73:456–464PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2015

Authors and Affiliations

  1. 1.BioChemical Engineering Program, College of EngineeringUniversity of GeorgiaAthensUSA
  2. 2.Centre for BiotechnologyAnna UniversityChennaiIndia

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