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Photocatalytic and antimicrobial properties of surgical implant coatings of titanium dioxide deposited though cathodic arc evaporation

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Abstract

Nanostructured crystalline titanium dioxide coatings deposited by cathodic arc evaporated on titanium grade five medical implant substrates were demonstrated to exhibit UV-induced photocatalytic activity that can be utilized to provide bactericidal effects against Staphylococcus epidermidis. The photocatalytic activity of the coatings was confirmed via degradation of Rhodamine B under UV illumination. A 90 % reduction of viable bacteria was achieved in a clinically suitable time of only 2 min with a UV dose of 2.4 J delivered at 365 nm. These results are encouraging for the development of antimicrobial surfaces in orthopedics and dentistry in order to prevent or treat post-surgical infections.

Purpose of work

To assess the possibility of employing photocatalysis for elimination of S. epidermidis, known to cause medical device related infections, under short enough times to be clinically useful on an implant surface produced with a technique that is suitable for mass production.

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Acknowledgments

The Swedish Science Council, The Carl Trygger Foundation, The Göran Gustafsson Foundation, The Swedish Foundation for Strategic Research and Vinnova are acknowledged for financially supporting our research.

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Authors and Affiliations

  1. Division for Nanotechnology and Functional Materials, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, Box 534, 75121, Uppsala, Sweden

    Mirjam Lilja, Johan Forsgren, Ken Welch & Maria Strømme

  2. Division of Applied Materials Science, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, Box 534, 75121, Uppsala, Sweden

    Håkan Engqvist

  3. Sandvik Tooling Sverige AB, Lerkrogsvägen 19, 12680, Stockholm, Sweden

    Mirjam Lilja & Maria Åstrand

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  1. Mirjam Lilja
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Correspondence to Håkan Engqvist or Maria Strømme.

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Lilja, M., Forsgren, J., Welch, K. et al. Photocatalytic and antimicrobial properties of surgical implant coatings of titanium dioxide deposited though cathodic arc evaporation. Biotechnol Lett 34, 2299–2305 (2012). https://doi.org/10.1007/s10529-012-1040-2

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  • DOI: https://doi.org/10.1007/s10529-012-1040-2

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