Abstract
The anti-inflammatory activity of the surfactin C derived from Bacillus subtilis isolate was investigated in lipopolysaccharide (LPS, 1 μg ml−1)-treated mouse RAW 264.7 cells. LPS increased mRNA transcription of cyclooxygenase (COX)-2, interleukin (IL)-1β and inducible nitric oxide synthase (iNOS). However, surfactin C at 50 μg ml−1 inhibited the LPS-induced increase in the transcription of IL-1β and iNOS and nitric oxide (NO) production in a dose-dependent manner.
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Hwang, MH., Lim, JH., Yun, HI. et al. Surfactin C inhibits the Lipopolysaccharide-induced Transcription of Interleukin-1β and Inducible Nitric Oxide Synthase and Nitric Oxide Production in Murine RAW 264.7 Cells. Biotechnol Lett 27, 1605–1608 (2005). https://doi.org/10.1007/s10529-005-2515-1
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DOI: https://doi.org/10.1007/s10529-005-2515-1