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Association of Intelectin 1 Gene rs2274907 A > T Polymorphism with Obesity, Type 2 Diabetes, Serum Intelectin-1 Levels and Lipid Profiles in Turkish Adults

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Abstract

The anti-inflammatory adipokine intelectin-1, which is encoded by the ITLN1 gene, is hypothesized to be linked to the pathogenesis of type 2 diabetes (T2DM) and obesity. The purpose of this study was to examine the effect of the ITLN1 gene polymorphism rs2274907 on obesity and T2DM in Turkish adults. The impact of genotype on lipid profiles and serum intelectin levels in the obese and diabetes groups was also investigated. Randomly selected 2266 adults (mean age, 55.0 ± 11.7 years; 51.2% women) participating in the population-based Turkish adult risk factor study were cross-sectionally analyzed. The genotyping of rs2274907 A > T polymorphism was performed by using the hybridization probe based LightSNiP assay in real-time PCR. T2DM were defined using the criteria of the American Diabetes Association. Obesity was described as Body mass index ≥ 30 kg/m2. Statistical analyses were used to investigate the association of genotypes with clinical and biochemical measurements. According to findings, there was no vital connection between the rs2274907 polymorphism and obesity, T2DM, or serum intelectin-1 level. The TA+AA carriers had significantly higher triglyceride levels (p = 0.007) compared with the TT carriers in both obese and T2DM women when adjusted for relevant covariates. ITLN1 rs2274907 polymorphism is not correlated with the risk of obesity and T2DM and not affect serum ITLN1 levels in Turkish adults. However, this polymorphism appears to be important in regulating triglyceride levels in obese and diabetic women.

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Data Availability

No dataset used.

Abbreviations

BMI:

Body mass index

HDL-C:

High-density lipoprotein cholesterol

ITLN1:

Intelectin-1

LDL-C:

Low-density lipoprotein cholesterol

T2DM:

Type 2 diabetes

TARF:

Turkish adult risk factor

TG:

Triglycerides

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Acknowledgements

This study was supported by the Research Support Unit of Istanbul University, Project 22361. Unconditional financial support was provided for the TARF study from the Turkish Society of Cardiology, Istanbul, Turkey.

Funding

This work was supported by the Research Support Unit of Istanbul University, Project 22361. Unconditional financial support was provided for the TARF study from the Turkish Society of Cardiology, Istanbul, Turkey. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

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Authors and Affiliations

  1. Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey

    Filiz Guclu-Geyik, Pınar Koseoglu, Gamze Guven, Neslihan Coban, Evrim Komurcu-Bayrak & Nihan Erginel-Unaltuna

  2. Department of Public Health, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey

    Gunay Can

  3. Biochemistry Laboratory, Institute of Cardiology, Istanbul University-Cerrahpaşa, Istanbul, Turkey

    Aysem Kaya

Authors
  1. Filiz Guclu-Geyik
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  2. Pınar Koseoglu
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  3. Gamze Guven
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  4. Gunay Can
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  5. Aysem Kaya
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  8. Nihan Erginel-Unaltuna
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Contributions

All authors contributed to the study conception and design. All authors read and approved the final manuscript. F.G-G. wrote the main manuscript text, did Investigation, Resources Supervision. P.K. wrote the material methods, Investigation, Writing, Visualization. G.G. Conceptualization, Methodology, Investigation, Writing, Supervision. G.C. Writing, Formal analysis. A.K. Writing, Resources. N.C. Conceptualization, Methodology, Writing. E.K-B. Conceptualization, Methodology, Writing. N.E-U. Conceptualization, Methodology, Writing.

Corresponding author

Correspondence to Filiz Guclu-Geyik.

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Competing interest

The authors declare no competing interests.

Ethical Approval

This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Istanbul Medical Faculty at Istanbul University (Date: June 10, 2016/No:2016/738).

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Guclu-Geyik, F., Koseoglu, P., Guven, G. et al. Association of Intelectin 1 Gene rs2274907 A > T Polymorphism with Obesity, Type 2 Diabetes, Serum Intelectin-1 Levels and Lipid Profiles in Turkish Adults. Biochem Genet 61, 2276–2292 (2023). https://doi.org/10.1007/s10528-023-10371-3

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