Abstract
Increasing reports demonstrate that long noncoding RNAs participate in the regulation of numerous malignancies, cervical cancer included. Although lncRNA LOXL1 antisense RNA 1 has been commonly accepted to be an oncogene in many cancers. Here, the role of LOXL1-AS1 in CC still need to be explored. In this study, LOXL1-AS1 was found elevated in CC tissues and cells. LOXL1-AS1 depletion restrained CC cell proliferation, migration, invasion, and angiogenesis in vivo. Furthermore, we found that LOXL1-AS1 upregulated Lysophospholipase 1 expression via sequestering miR‐526b-5p. Rescue assays revealed that overexpression of LYPLA1 reversed the LOXL1-AS1 silencing-induced inhibitory effects on the malignant phenotypes of CC cells. To conclude, this study showed that LOXL1-AS1 facilitates cellular process in CC via functioning as a miR‐526b-5p sponge.
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Data Availability
The datasets used during the current study are available from the corresponding author on reasonable request.
Change history
09 November 2022
A Correction to this paper has been published: https://doi.org/10.1007/s10528-022-10301-9
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YZ conceived and designed the experiments. YZ, MZ, LZ, PY, JZ, YW and HW carried out the experiments. YZ and HW analyzed the data. YZ and HW drafted the manuscript. All authors agreed to be accountable for all aspects of the work. All authors have read and approved the final manuscript.
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Zhang, Y., Zheng, M., Zhang, L. et al. LncRNA LOXL1-AS1 Facilitates the Oncogenic Character in Cervical Cancer by the miR-526b-5p /LYPLA1 Axis. Biochem Genet 60, 1298–1312 (2022). https://doi.org/10.1007/s10528-021-10182-4
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DOI: https://doi.org/10.1007/s10528-021-10182-4