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The Role of Long Non-coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies

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Abstract

Nuclear enriched abundant transcript 1 (NEAT1), consisting of two kinds of lncRNAs of 3.7 kB NEAT1-1 and 23 kB NEAT1-2, can be highly expressed in organs and tissues such as the ovary, prostate, colon, and pancreas, and is involved in paraspeckle formation and mRNA editing and gene expression. Therefore, NEAT1 is a potential biomarker for the treatment of a variety of diseases, which may be caused by two factors (isoforms of NEAT1 and NEAT1 sponging miRNA as ceRNA). However, there is still much confusion about the mechanism and downstream effector between the abnormal expression of NEAT1 and various diseases. This review summarizes recent research progress on NEAT1 in cancer and other pathologies and provides a more reliable theoretical basis for the treatment of related diseases.

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Acknowledgements

This work was supported by National Natural Science Foundation of China (No. 81871835), Shanghai Frontiers Science Research Base of Exercise and Metabolic Health and Shanghai Key Laboratory for Human Athletic Ability Development and Support (Shanghai University of Sport) (No. 11DZ2261100). We would like to thank all authors for contributing to this study.

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  1. School of Kinesiology, Shanghai University of Sport, Shanghai, 200438, China

    Miao Zhang, Jianmin Guo, Lifei Liu, Mei Huang, Yuexuan Li & Jun Zou

  2. School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia

    Samuel Bennett & JiaKe Xu

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  1. Miao Zhang
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  2. Jianmin Guo
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Zhang, M., Guo, J., Liu, L. et al. The Role of Long Non-coding RNA, Nuclear Enriched Abundant Transcript 1 (NEAT1) in Cancer and Other Pathologies. Biochem Genet 60, 843–867 (2022). https://doi.org/10.1007/s10528-021-10138-8

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