Skip to main content

Advertisement

Log in

Opportunities for Using an Accelerator-Based Epithermal Neutron Source for Boron Neutron Capture Therapy

  • Theory and Design
  • Published:
Biomedical Engineering Aims and scope

Specific design features and main characteristics of a compact accelerator-based epithermal neutron source for boron neutron capture therapy are described. High quality of the neutron flux generated by the accelerator-based source has been experimentally confirmed. The opportunities for medical use of the accelerator-based epithermal neutron source in oncological centers for boron neutron capture therapy are assessed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Locher, G., “Biological effects and therapeutic possibilities of neutrons,” Am. J. Roentgenol. Radium Ther., 36, 1-13 (1936).

    Google Scholar 

  2. Sauerwein, W., Neutron Capture Therapy. Principles and Applications, Springer (2012).

  3. Iarullina, A. I., Kanygin, V. V., Kichigin, A. I., et al., “Boron neutron capture therapy of brain tumors: difficulties and modern solutions,” Tikhook. Med. Zh., No. 4, 4-10 (2015).

    Google Scholar 

  4. Barth, R., Vicente, M., Harling, O., et al., “Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer,” Radiat. Oncol., 7, 146 (2012).

    Article  Google Scholar 

  5. Byvaltsev, V. A., Stepanov, I. A., Belykh, E. G., et al., “Molecular biology of highly malignant gliomas,” Sib. Med. Zh. (Irkutsk), 133, No. 2, 5-9 (2015).

    Google Scholar 

  6. Kanygin, V. V., Kichigin, A. I., Gubanova, N. V., et al., “Capabilities of boron neutron capture therapy of malignant tumors of the brain,” Vestn. Rentgenol. Radiol., No. 6, 36-42 (2015).

  7. Taskaev, S. Yu., “An accelerator-based source of epithermal neutrons,” Fiz. Elem. Chast. Atom. Yadra, 46, No. 6, 1770-1830 (2015).

    Google Scholar 

  8. Ivanov, A. A., Kasatov, D. A., Koshkarev, A. M., et al., “Generation of 5-mA proton beam in a tandem accelerator with vacuum insulation,” Pis. ZhTF, 42, No. 12, 1-8 (2016).

    Google Scholar 

  9. Volkova, O. Yu., Mechetina, L. V., Taranin, A. V., et al., “The effect of neutron radiation on viability of tumor cells cultivated in the presence of the 10B boron isotope,” Vestn. Rentgenol. Radiol., 97, No. 5, 283-288 (2016).

    Article  Google Scholar 

  10. Zaboronok, A., Byvaltsev, V., Kanygin, V., et al., “Boron-neutron capture therapy in Russia: Preclinical evaluation of efficacy and perspectives of its application in neurooncology,” New Armen. Med. J., 11, No. 1, 6-15 (2017).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to A. I. Iarullina.

Additional information

Translated from Meditsinskaya Tekhnika, Vol. 52, No. 2, Mar.-Apr., 2018, pp. 1-3.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Taskaev, S.Y., Kanygin, V.V., Byvaltsev, V.A. et al. Opportunities for Using an Accelerator-Based Epithermal Neutron Source for Boron Neutron Capture Therapy. Biomed Eng 52, 73–76 (2018). https://doi.org/10.1007/s10527-018-9785-0

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10527-018-9785-0

Navigation