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Development of an Accelerator-Based Epithermal Neutron Source for Boron Neutron Capture Therapy

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Abstract

The paper presents a review of the current state of development of accelerator-based epithermal neutron sources for boron neutron capture therapy (BNCT), a promising method for the treatment of malignant tumors. Special attention is paid to an epithermal neutron source based on a new type of accelerator of charged particles: a tandem accelerator with vacuum insulation and a lithium neutron-producing target.

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ACKNOWLEDGMENTS

We are grateful to the BNCT team: B.F. Bayanov, I.N. Sorokin, A.N. Makarov, D.A. Kasatov, I.M. Shchudlo, T.V. Sycheva, G.M. Ostreinov, L. Zaidi, I.A. Kolesnikov, E.O. Sokolova, A.M. Koshkarev, and T.A. Bykov for their help in the research and upgrading the accelerator-based epithermal neutron source, to A. Badrutdinov, Y. Higashi, F. Suzuki, and H. Sugawara for the successful experiment on the observation of blistering, V.V. Kanygin, A.I. Kasatova, A.I. Kichigin, L.V. Mechetina, O.Yu. Volkova, A.A. Zaboronok, E. Sato, K. Nakai, and A. Matsumura for successful experiments with cell cultures, and to N.V. Gubanova for the successful experiment with laboratory animals.

Funding

This work was supported by the Russian Science Foundation (grant no. 14-32-00006-P), the Budker Institute of Nuclear Physics of the Siberian Branch of the Russian Academy of Sciences, and Novosibirsk State University.

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Authors and Affiliations

  1. Budker Institute of Nuclear Physics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    S. Yu. Taskaev

  2. Novosibirsk State University, 630090, Novosibirsk, Russia

    S. Yu. Taskaev

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  1. S. Yu. Taskaev
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Correspondence to S. Yu. Taskaev.

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Translated by E. Chernokozhin

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Taskaev, S.Y. Development of an Accelerator-Based Epithermal Neutron Source for Boron Neutron Capture Therapy. Phys. Part. Nuclei 50, 569–575 (2019). https://doi.org/10.1134/S1063779619050228

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  • DOI: https://doi.org/10.1134/S1063779619050228

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