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Development of the Method of Magnetic Neutron Capture Therapy of Cancer

  • Human and Animal Physiology
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Abstract

The method of magnetic neutron capture therapy (MNTC) of cancer can be described as a combination of two methods: the targeted delivery of drugs using magnetic carriers and the proper neutron capture therapy which consists in tumor irradiation with thermal neutrons following the delivery of 10B compounds to the tumor site. Two-component ultradispersed particles containing Fe and C were tested as magnetic adsorbents of boron phenylalanine and borax. The quantities of absorbed borax proved sufficient for high concentration of boron atoms at the tumor site. The kinetics of boron release to saline substantiates the application of Fe-B (10%) ultradispersed particles for efficient MNTC. Both particle types have high magnetization and magnetic homogeneity, can form stable magnetic suspensions, and have low toxicity.

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REFERENCES

  • Advances in Neutron Capture Therapy, New York: Elsevier, 1997, vols. 1–2.

  • Kuznetsov, A.A., Kholodov, L.E., Filippov, V.I., et al., RF Patent No. 172256, 1989 (unpublished).

  • Kuznetsov, A.A., Harutyunyan, A.R., Dobrinsky, E.K., Filippov, V.I., Malenkov, A.G., Vanin, A.F., and Kuznetsov, O.A., Ferro-Carbon Particles: Preparation and Clinical Applications, in Scientific and Clinical Applications of Magnetic Carriers, New York: Plenum, 1997, pp. 379–387.

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  • Kuznetsov, A.A., Filippov, V.I., Kuznetsov, O.A., Gerlivanov, V.G., Dobrinsky, E.K., and Malashin, S.I., New Ferro-Carbon Adsorbent for Magnetically Guided Transport of Anti-Cancer, J. Magn. Magn. Mater., 1999, vol. 194, pp. 22–29.

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991, Russia

    A. A. Kuznetsov, S. N. Podoinitsyn, V. I. Filippov & L. Kh. Komissarova

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  1. A. A. Kuznetsov
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  2. S. N. Podoinitsyn
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  3. V. I. Filippov
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  4. L. Kh. Komissarova
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Translated from Izvestiya Akademii Nauk, Seriya Biologicheskaya, No. 4, 2005, pp. 448–452.

Original Russian Text Copyright © 2005 by Kuznetsov, Podoinitsyn, Filippov, Komissarova.

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Kuznetsov, A.A., Podoinitsyn, S.N., Filippov, V.I. et al. Development of the Method of Magnetic Neutron Capture Therapy of Cancer. Biol Bull Russ Acad Sci 32, 371–374 (2005). https://doi.org/10.1007/s10525-005-0114-2

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  • DOI: https://doi.org/10.1007/s10525-005-0114-2

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