Abstract
The linear no-threshold (LNT) hypothesis is still the ruling concept which dictates the radiation protection health policy and regulations. However, more and more studies show that not only that low dose radiation pose no danger to our health, but also exhibits clear beneficial health effects. Here, we evaluated the correlative links of the natural sources of radiation—terrestrial radiation (TR), cosmic radiation (CR), and Radon-222, with life expectancy, the most integrative index of population health. The results of this study show that the different sources of natural radiation display positive correlative links to life expectancy, which is in line with the hypothesis of radiation hormesis.
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Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author upon request.
Abbreviations
- BR:
-
Background radiation
- CR:
-
Cosmic radiation
- LE:
-
Life expectancy
- LNT:
-
Linear no-threshold
- Radium-226:
-
226Ra
- Radon-222:
-
222Rn
- Std. Beta:
-
Standardized beta coefficient
- TR:
-
Terrestrial radiation
References
Calabrese EJ, Priest ND, Kozumbo WJ (2021) Thresholds for carcinogens. Chem Biol Interact 341:109464. https://doi.org/10.1016/j.cbi.2021.109464
Cardarelli JJ 2nd, Ulsh BA (2018) It is time to move beyond the linear no-threshold theory for low-dose radiation protection. Dose Response 16(3):1559325818779651. https://doi.org/10.1177/1559325818779651
Cohen BL (1995) Test of the linear-no threshold theory of radiation carcinogenesis for inhaled radon decay products. Health Phys 68:157–174. https://doi.org/10.1097/00004032-199502000-00002
Csaba G (2019) Hormesis and immunity: a review. Acta Microbiol Immunol Hung 66:155–168. https://doi.org/10.1556/030.65.2018.036
Ćujić M, Janković Mandić L, Petrović J, Dragović R, Đorđević M, Đokić M, Dragović S (2021) Radon-222: environmental behavior and impact to (human and non-human) biota. Int J Biometeorol 65:69–83. https://doi.org/10.1007/s00484-020-01860-w
David E, Wolfson M, Fraifeld VE (2021) Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm. Biogerontology 22:189–195. https://doi.org/10.1007/s10522-020-09909-4
Deetjen P (1998) Biological and therapeutical properties of radon. In: Katase A, Shimo M (eds) Radon and thoron in the human environment. World Scientific Pub Co Inc, Fukuoka, pp 515–522
Degu Belete G, Alemu Anteneh Y (2021) General overview of radon studies in health hazard perspectives. J Oncol 2021:6659795. https://doi.org/10.1155/2021/6659795
Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV (2021) Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (albany NY) 13:24485–24499. https://doi.org/10.18632/aging.203736
Field RW, Krewski D, Lubin JH, Zielinski JM, Alavanja M, Catalan VS, Klotz JB, Létourneau EG, Lynch CF, Lyon JL, Sandler DP, Schoenberg JB, Steck DJ, Stolwijk JA, Weinberg C, Wilcox HB (2006) An overview of the North American residential radon and lung cancer case-control studies. J Toxicol Environ Health A 69:599–631. https://doi.org/10.1080/15287390500260960
Grzywa-Celińska A, Krusiński A, Mazur J, Szewczyk K, Kozak K (2020) Radon—the element of risk. The impact of radon exposure on human health. Toxics 8:120. https://doi.org/10.3390/toxics8040120
Jaworowski Z (1999) Radiation risk and ethics. Phys Today 52:24–29. https://doi.org/10.1063/1.882810
Jaworowski Z (2010) Radiation hormesis—a remedy for fear. Hum Exp Toxicol 29:263–270. https://doi.org/10.1177/0960327110363974
Kang JK, Seo S, Jin YW (2019) Health effects of radon exposure. Yonsei Med J 60:597–603. https://doi.org/10.3349/ymj.2019.60.7.597
Katz R, Waligórski MPR (1994) On the linear extrapolation to low doses. Radiat Prot Dosimetry 52:197–199. https://doi.org/10.1093/oxfordjournals.rpd.a082185
Lau YS, Chew MT, Alqahtani A, Jones B, Hill MA, Nisbet A, Bradley DA (2021) Low dose ionising radiation-induced hormesis: therapeutic implications to human health. Appl Sci 11:8909. https://doi.org/10.3390/app11198909
Lehrer S, Rosenzweig KE (2015) Lung cancer hormesis in high impact states where nuclear testing occurred. Clin Lung Cancer 16:152–155. https://doi.org/10.1016/j.cllc.2014.09.010
Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S (2018) An epigenetic biomarker of aging for lifespan and healthspan. Aging (albany NY) 10:573–591. https://doi.org/10.18632/aging.101414
Luckey TD (1999) Nurture with ionizing radiation: a provocative hypothesis. Nutr Cancer 34(1):1–11. https://doi.org/10.1207/S15327914NC340101
Luckey TD (2006) Radiation hormesis: the good, the bad, and the ugly. Dose Response 4(3):169–190. https://doi.org/10.2203/dose-response.06-102.Luckey
Nuclear Regulatory Commission (2021) Linear no-threshold model and standards for protection against radiation. Fed Reg 86:45923–45936. https://www.govinfo.gov/content/pkg/FR-2021-08-17/pdf/2021-17475.pdf
Pylak M, Fornalski KW, Reszczyńska J, Kukulski P, Waligórski MPR, Dobrzyński L (2021) Analysis of indoor radon data using bayesian, random binning, and maximum entropy methods. Dose Response 19:15593258211009336. https://doi.org/10.1177/15593258211009337
Schauer DA, Linton OW (2009) NCRP Report No. 160, ionizing radiation exposure of the population of the United States, medical exposure—are we doing less with more, and is there a role for health physicists? Health Phys 97:1–5. https://doi.org/10.1097/01.HP.0000356672.44380.b7
Scott BR (2011) Residential radon appears to prevent lung cancer. Dose Response 9:444–464. https://doi.org/10.2203/dose-response.11-027.Scott
Scott BR, Tharmalingam S (2019) The LNT model for cancer induction is not supported by radiobiological data. Chem Biol Interact 301:34–53. https://doi.org/10.1016/j.cbi.2019.01.013
Seale K, Horvath S, Teschendorff A, Eynon N, Voisin S (2022) Making sense of the ageing methylome. Nat Rev Genet. https://doi.org/10.1038/s41576-022-00477-6
Shahbazi-Gahrouei D, Gholami M, Setayandeh SA (2013) A review on natural background radiation. Adv Biomed Res 2:65. https://doi.org/10.4103/2277-9175.115821
Shibamoto Y, Nakamura H (2018) Overview of biological, epidemiological, and clinical evidence of radiation hormesis. Int J Mol Sci 19:2387. https://doi.org/10.3390/ijms19082387
Thompson RE (2010) Epidemiological evidence for possible radiation hormesis from radon exposure: a case-control study conducted in Worcester, MA. Dose Response 9:59–75. https://doi.org/10.2203/dose-response.10-026.Thompson
Thompson RE (2014) Radon. In: Wexler P (ed) Encyclopedia of toxicology, 3rd edn. Elsevier Science Publishing Co Inc, Academic Press, San Diego, pp 46–50
Thompson RE, Nelson DF, Popkin JH, Popkin Z (2008) Case-control study of lung cancer risk from residential radon exposure in Worcester county, Massachusetts. Health Phys 94:228–241. https://doi.org/10.1097/01.HP.0000288561.53790.5f
Vaiserman A, Koliada A, Zabuga O, Socol Y (2018) Health impacts of low-dose ionizing radiation: current scientific debates and regulatory issues. Dose Response 16:1–27. https://doi.org/10.1177/1559325818796331
Vaiserman A, Cuttler JM, Socol Y (2021) Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders. Biogerontology 22:145–164. https://doi.org/10.1007/s10522-020-09908-5
Welsh J, Sacks B, Siegel JA (2017) Time to eliminate LNT: the NRC needs to adopt LT and eliminate ALARA. Nucl Med Biomed Imaging. https://doi.org/10.15761/NMBI.1000118
Zarnke AM, Tharmalingam S, Boreham DR, Brooks AL (2019) BEIR VI radon: the rest of the story. Chem Biol Interact 301:81–87. https://doi.org/10.1016/j.cbi.2018.11.012
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David, E., Bitan, R., Atlas, S. et al. Correlative links between natural radiation and life expectancy in the US population. Biogerontology 23, 425–430 (2022). https://doi.org/10.1007/s10522-022-09971-0
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DOI: https://doi.org/10.1007/s10522-022-09971-0