Skip to main content

Advertisement

SpringerLink
Log in

Biogerontology in Austria

  • Review Article
  • Published:
Biogerontology Aims and scope Submit manuscript

Abstract

In Austria significant progress in the field of biogerontology has been achieved in the past years. Biogerontological research is performed in academic and extramural institutions. The Institute for Biomedical Aging Research of the Austrian Academy of Science at Innsbruck is the largest institution dealing with biogerontology in Austria. Moreover, gerontologic research is performed at the Universities of Salzburg and Graz, the Medical Universities of Vienna, Innsbruck and Graz, the University of Veterinary Medicine (Vienna) and the University of Natural Resources and Applied Life Sciences (Vienna). This article describes the work of selected research groups involved in biogerontology in a geographic arrangement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Büttner S, Eisenberg T, Carmona-Gutierrez D, Ruli D, Knauer H, Ruckenstuhl C, Sigrist C, Wissing S, Kollroser M, Fröhlich KU, Sigrist S, Madeo F (2007) Endonuclease G regulates budding yeast life and death. Mol Cell 25(2):233–246

    Article  PubMed  Google Scholar 

  • Chiocchetti A, Zhou J, Zhu H, Karl T, Haubenreisser O, Rinnerthaler M, Heeren G, Oender K, Bauer J, Hintner H, Breitenbach M, Breitenbach-Koller L (2007) Ribosomal proteins Rp110 and Rps6 are potent regulators of yeast replicative life span. Exp Gerontol 42:275–286

    Article  PubMed  CAS  Google Scholar 

  • Eisenberg T, Knauer H, Schauer A et al (2009) Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 11(11):1305–1314

    Article  PubMed  CAS  Google Scholar 

  • Eisenberg T, Carmona-Gutierrez D, Büttner S, Tavernarakis N, Madeo F (2010) Necrosis in yeast. Apoptosis [Epub ahead of print]

  • Fehrer C, Brunauer R, Laschober G, Unterluggauer H, Reitinger S, Kloss F, Gülly C, Gaßner R, Lepperdinger G (2007) Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their life span. Aging Cell 6:745–757

    Article  PubMed  CAS  Google Scholar 

  • Flatt T, Tu MP, Tatar M (2005) Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history. Bioessays 27(10):999–1010

    Article  PubMed  CAS  Google Scholar 

  • Flatt T, Min KJ, D’Alterio C, Villa-Cuesta E, Cumbers J, Lehmann R, Jones DL, Tatar M (2008a) Drosophila germ-line modulation of insulin signaling and lifespan. Proc Natl Acad Sci USA 105(17):6368–6373

    Article  PubMed  CAS  Google Scholar 

  • Flatt T, Heyland A, Rus F, Porpiglia E, Sherlock C, Yamamoto R, Garbuzov A, Palli SR, Tatar M, Silverman N (2008b) Hormonal regulation of the humoral innate immune response in Drosophila melanogaster. J Exp Biol 211:2712–2724

    Article  PubMed  CAS  Google Scholar 

  • Grillari J, Hohenwarter O, Grabherr RM, Katinger H (2000) Subtractive hybridization of mRNA from early passage and senescent endothelial cells. Exp Gerontol 35:187–197

    Article  PubMed  CAS  Google Scholar 

  • Hütter E, Skovbro M, Lener B, Prats C, Rabøl R, Dela F, Jansen-Dürr P (2007) Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle. Aging Cell 6:245–256

    Article  PubMed  Google Scholar 

  • Kirchner L, Chen WQ, Afjehi-Sadat L, Viidik A, Skalicky M, Höger H, Lubec G (2008) Hippocampal metabolic proteins are modulated in voluntary and teadmill exercise rats. Exp Neurol 212:145–151

    Article  PubMed  CAS  Google Scholar 

  • Knoflach M, Bernhard D, Wick G (2005) Anti-HSP60 immunity is already associated with atherosclerosis early in life. Ann N Y Acad Sci 1051:323–331

    Article  PubMed  CAS  Google Scholar 

  • Knoflach M, Kiechl S, Mayrl B, Kind M, Gaston JS, van der Zee R, Faggionato A, Mayr A, Willeit J, Wick G (2007) T-cell reactivity against HSP60 relates to early but not advanced atherosclerosis. Atherosclerosis 195:333–338

    Article  PubMed  CAS  Google Scholar 

  • Laun P, Pichova A, Madeo F, Fuchs J, Ellinger A, Kohlwein S, Dawes I, Fröhlich KU, Breitenbach M (2001) Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol 39:1166–1173

    Article  PubMed  CAS  Google Scholar 

  • Laun P, Rinnerthaler M, Bogengruber E, Heeren G, Breitenbach M (2006) Yeast as a model for chronological and reproductive aging—a comparison. Exp Gerontol 41:1208–1212

    Article  PubMed  CAS  Google Scholar 

  • Madeo F, Eisenberg T, Büttner S, Ruckenstuhl C, Kroemer G (2010) Spermidine: a novel autophagy inducer and longevity elixir. Autophagy 6(1):160–162

    Article  PubMed  Google Scholar 

  • Matusovsky OS, Shelud’ko NS, Permyakova TV, Zukowska M, Sobieszek A (2010) Catch muscle of bivalve molluscs contains myosin-and twitchin-associated protein kinase phosphorylating myorod. Biochim Biophys Acta (Epub ahead of print)

  • Narath E, Skalicky M, Viidik A (2001) Voluntary and forced exercise influence the survival and body composition of ageing male rats differently. Exp Gerontol 36:1699–1711

    Article  PubMed  CAS  Google Scholar 

  • Pietschmann P, Skalicky M, Kneissel M, Rauner M, Hofbauer G, Stupphann D, Viidik A (2007) Bone structure and metabolism in a rodent model of male senile osteoporosis. Exp Gerontol 42:1099–1108

    Article  PubMed  CAS  Google Scholar 

  • Rauner M, Sipos W, Pietschmann P (2007) Osteoimmunology. Int Arch Allergy Immunol 143:31–48

    Article  PubMed  Google Scholar 

  • Rauner M, Sipos W, Goettsch C, Wutzl A, Foisner R, Pietschmann P, Hofbauer LC (2009) Inhibition of lamin A/C attenuates osteoblast differentiation and enhances RANKL-dependent osteoclastogenesis. J Bone Miner Res 24:78–86

    Article  PubMed  CAS  Google Scholar 

  • Rockenfeller P, Madeo F (2008) Apoptotic death of ageing yeast. Exp Gerontol 43:876–881

    Article  PubMed  CAS  Google Scholar 

  • Rossmann A, Henderson B, Heidecker B, Seiler R, Fraedrich G, Singh M, Parson W, Keller M, Grubeck-Loebenstein B, Wick G (2008) T-cells from advanced atherosclerotic lesions recognize hHSP60 and have a restricted T-cell receptor repertoire. Exp Gerontol 43:229–237

    Article  PubMed  CAS  Google Scholar 

  • Santer FR, Bacher N, Moser B, Morandell D, Ressler S, Firth SM, Spoden GA, Sergi C, Baxter RC, Jansen-Dürr P, Zwerschke W (2006) Nuclear insulin-like growth factor binding protein-3 induces apoptosis and is targeted to ubiquitin/proteasome-dependent proteolysis. Cancer Res 66:3024–3033

    Article  PubMed  CAS  Google Scholar 

  • Saurwein-Teissl M, Lung TL, Marx F, Gschösser C, Asch E, Blasko I, Parson W, Böck G, Schönitzer D, Trannoy E, Grubeck-Loebenstein B (2002) Lack of antibody production following immunization in old age: Association with CD8(+)CD28(−) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 168:5893–5899

    PubMed  CAS  Google Scholar 

  • Schraml E, Quan P, Stelzer I, Fuchs R, Skalicky M, Viidik A, Schauenstein K (2007) Norepinephrine treatment and aging lead to systemic and intracellular oxidative stress in rats. Exp Gerontol 42:1072–1078

    Article  PubMed  CAS  Google Scholar 

  • Sipos W, Rauner M, Skalicky M, Viidik A, Hofbauer G, Schett G, Redlich K, Lang S, Pietschmann P (2008) Running has a negative effect on bone metabolism and proinflammatory status in male aged rats. Exp Gerontol 43:578–583

    Article  PubMed  CAS  Google Scholar 

  • Skalicky M, Narath E, Viidik A (2001) Housing conditions influence the survival and body composition of ageing rats. Exp Gerontol 36:159–170

    Article  PubMed  CAS  Google Scholar 

  • Spoden GA, Rostek U, Lechner S, Mitterberger M, Mazurek S, Zwerschke W (2009) Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply. Exp Cell Res 315:2765–2774

    Article  PubMed  CAS  Google Scholar 

  • Untergasser G, Rumpold H, Plas E, Madersbacher S, Berger P (2001) A low molecular weight fraction of human seminal plasma activates adenylyl cyclase and induces caspase 3-independent apoptosis in prostatic epithelial cells by decreasing mitochondrial potential and Bcl-2/Bax ratio. FASEB J 15:673–683

    Article  PubMed  CAS  Google Scholar 

  • Voglauer R, Chang MW, Dampier B, Wieser M, Baumann K, Sterovsky T, Schreiber M, Katinger H, Grillari J (2006) SNEV overexpression extends the life span of human endothelial cells. Exp Cell Res 312:746–759

    Article  PubMed  CAS  Google Scholar 

  • Wick G (2000) Summary: experimental gerontology in Austria. Exp Gerontol 35:513–519

    Article  PubMed  CAS  Google Scholar 

  • Wieser M, Stadler G, Jennings P, Streubel B, Pfaller W, Ambros P, Riedl C, Katinger H, Grillari J, Grillari-Voglauer R (2008) hTERT alone immortalizes epithelial cells of renal proximal tubules without changing their functional characteristics. Am J Physiol Renal Physiol 295:F1365–F1375

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

The work of Peter Pietschmann is supported by the Austrian Science Fund (Grant # P20239-B13). Johannes Grillari is supported by NRN Grant S93-06 of the Austrian Science Fund, the GEN-AU Project 820982 “Non-coding RNAs” as well as grants by the Herzheimer’sche Familienstiftung and CE.R.I.E.S. Beatrix Grubeck-Loebenstein is supported by the Austrian Science Fund (Grant # NFN S9301) as well as by the EU project MARK-AGE (Grant # HEALTH-F4-2008-200880) and the EU network of Excellence LifeSpan (Grant # LSHG-CT-2007-036894).

Author information

Authors and Affiliations

  1. Department of Pathophysiology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Währinger Gürtel 18–20, 1090, Vienna, Austria

    Ursula Azizi-Semrad & Peter Pietschmann

  2. Institute of Applied Microbiology, University of Natural Resources and Applied Life Sciences Vienna, Vienna, Austria

    Johannes Grillari

  3. Institute for Biomedical Aging Research, Austrian Academy of Science, Innsbruck, Austria

    Beatrix Grubeck-Loebenstein

Authors
  1. Ursula Azizi-Semrad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Johannes Grillari
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Beatrix Grubeck-Loebenstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter Pietschmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Peter Pietschmann.

Additional information

Parts of the text on the Institute of Biomedical Aging Research of the Austrian Academy of Sciences were modified from the Progress Report of the Austrian Academy of Sciences 2006–2007, published by Austrian Academy of Sciences, pp 22–24 with kind permission of the Austrian Academy of Sciences.

Appendix

Appendix

See Table 1.

Table 1 Selected institutions performing research in biogerontology or experimental gerontology in Austria
Full size table

Rights and permissions

Reprints and permissions

About this article

Cite this article

Azizi-Semrad, U., Grillari, J., Grubeck-Loebenstein, B. et al. Biogerontology in Austria. Biogerontology 12, 3–10 (2011). https://doi.org/10.1007/s10522-010-9267-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10522-010-9267-6

Keywords

Search

Navigation