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Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression

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A central issue in psychiatric genetics is whether positive findings replicate. Zubenko et al. (2002b, Mol. Psychiatry 7:460–467) reported an association of the 124-bp allele of D2S2944 with recurrent early-onset major depression for females. We tested for association of this allele to continuous measures of anxiety, depression and neuroticism in a Dutch sample of 347 males and 448 females, and to DSM-IV major depression in a subsample of 210 males and 295 females. The association of the 124-bp allele to depression in females was not replicated, but there were significant associations (not significant after correction for multiple testing) with anxiety and anxious depression in males. However, the association occurred in the absence of evidence for linkage in this region on chromosome 2.

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Acknowledgements

This study was supported by the Netherlands Organization for Scientific Research (NWO 904-61-090), NIH (MH-059160) and the Centre for Neurogenomics and Cognition Research (CNCR) of the Vrije Universiteit, Amsterdam. We are grateful for the careful reading of the manuscript by two anonymous reviewers.

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Authors and Affiliations

  1. Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands

    A. Leo Beem, Eco J. C. de Geus, Jouke-Jan Hottenga, Gonneke Willemsen & Dorret I. Boomsma

  2. Section Molecular Epidemiology, Sylvius Laboratory, Leiden University Medical Centre, Leiden, The Netherlands

    P. Eline Slagboom

  3. Departments of Genetics, Psychiatry, & Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA

    Patrick F. Sullivan

  4. Department of Biological Psychology, Vrije Universiteit, van der Boechortstraat 1, 1081 BT, Amsterdam, The Netherlands

    A. Leo Beem

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  1. A. Leo Beem
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Correspondence to A. Leo Beem.

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Beem, A.L., Geus, E.J.C.d., Hottenga, JJ. et al. Combined Linkage and Association Analyses of the 124-bp Allele of Marker D2S2944 with Anxiety, Depression, Neuroticism and Major Depression. Behav Genet 36, 127–136 (2006). https://doi.org/10.1007/s10519-005-9006-y

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