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Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus

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We studied the relationship between the HSPA5 gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the HSPA5 gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes rs55736103-T/T, rs12009-G/G, and rs391957-T/C-T/T are associated with increased risk of type 2 diabetes in females. A rare haplotype, rs55736103C-rs12009A-rs391957T HSPA5, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the HSPA5 gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time.

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Authors and Affiliations

  1. Kursk State Medical University, Ministry of Health of the Russian Federation, Kursk, Russia

    E. Yu. Klyosova, Yu. E. Azarova, E. A. Ilyina, N. V. Goryainova & A. V. Polonikov

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  1. E. Yu. Klyosova
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  2. Yu. E. Azarova
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  3. E. A. Ilyina
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  4. N. V. Goryainova
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  5. A. V. Polonikov
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Correspondence to E. Yu. Klyosova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 11, pp. 616-620, November, 2023

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Klyosova, E.Y., Azarova, Y.E., Ilyina, E.A. et al. Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus. Bull Exp Biol Med 176, 599–602 (2024). https://doi.org/10.1007/s10517-024-06075-2

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  • DOI: https://doi.org/10.1007/s10517-024-06075-2

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