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The Effect of the Toxic Dose of Baclofen on Selected Parameters of the Cardiovascular and Respiratory Systems

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The effect of the toxic dose of the muscle relaxant baclofen on the parameters of the cardiovascular and respiratory systems was studied in adult male Wistar rats (n=20). Systolic and diastolic BP, HR, and respiratory rate were measured; histological changes in the lungs 3, 4.5, and 24 h after drug administration. Baclofen was administered orally in a sublethal toxic dose of 85 mg/kg under anesthesia. Cardiac activity was analyzed using RSM physiological indicators monitoring system with MouseMonitor S (Indus Instruments) software. Histological examination was performed by light microscopy. Baclofen significantly decreased the respiratory rate and increased HR and BP. Histological examination of the lungs revealed a complex of general pathological processes, such as local circulatory disorders (venular and capillary fullness, sludge), leukocyte infiltration of the interalveolar septa and their thickening due to edema. These findings can be used to estimate the time elapsed after baclofen treatment.

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Authors and Affiliations

  1. Institute of Medicine, Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

    O. L. Romanova, M. L. Blagonravov & V. I. Torshin

  2. A. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia

    O. L. Romanova & P. G. Dzhuvalyakov

  3. Federal Research Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia

    A. V. Ershov

  4. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    A. V. Ershov, M. A. Kislov & A. M. Magulaev

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  1. O. L. Romanova
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  2. M. L. Blagonravov
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  3. V. I. Torshin
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  4. P. G. Dzhuvalyakov
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  5. A. V. Ershov
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  6. M. A. Kislov
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  7. A. M. Magulaev
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Correspondence to O. L. Romanova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 6, pp. 734-738, June, 2023

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Romanova, O.L., Blagonravov, M.L., Torshin, V.I. et al. The Effect of the Toxic Dose of Baclofen on Selected Parameters of the Cardiovascular and Respiratory Systems. Bull Exp Biol Med 175, 777–780 (2023). https://doi.org/10.1007/s10517-023-05945-5

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  • DOI: https://doi.org/10.1007/s10517-023-05945-5

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