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Modern Concept of Molecular Diagnostics of Allergy to Dogs

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Bulletin of Experimental Biology and Medicine Aims and scope

The number of people suffering from allergies is increasing worldwide every year. With the prevalence of domestic animals, especially dogs, allergens associated with them can be found ubiquitously, thereby increasing the risk of anaphylaxis in sensitized individuals. Currently, there are 8 known dog allergens, but not all of them have been thoroughly studied. The commonly used skin prick tests often fall short and fail to provide a comprehensive assessment of a patient’s condition, thus making allergy diagnosis challenging. Fortunately, the introduction of new allergy diagnostic methods has made it possible to accurately identify clinically significant allergens for patients. These findings can then be used to prescribe appropriate therapy or provide specific recommendations to the patients. This review focuses on the most important dog allergens and modern allergy diagnostic techniques that are gradually being incorporated into medical practice, thus expanding the capabilities of allergists.

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References

  1. Zahradnik E, Raulf M. Animal allergens and their presence in the environment. Front. Immunol. 2014;5:76. https://doi.org/10.3389/fimmu.2014.00076

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Chan SK, Leung DYM. Dog and Cat Allergies: Current State of Diagnostic Approaches and Challenges. Allergy Asthma Immunol. Res. 2018;10(2):97-105. https://doi.org/10.4168/aair.2018.10.2.97

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Hugg TT, Jaakkola MS, Ruotsalainen R, Pushkarev V, Jaakkola JJ. Exposure to animals and the risk of allergic asthma: a population-based cross-sectional study in Finnish and Russian children. Environ. Health. 2008;7:28. https://doi.org/10.1186/1476-069X-7-28

    Article  PubMed  PubMed Central  Google Scholar 

  4. Mandhane PJ, Sears MR, Poulton R, Greene JM, Lou WY, Taylor DR, Hancox RJ. Cats and dogs and the risk of atopy in childhood and adulthood. J. Allergy Clin. Immunol. 2009;124(4):745-750.e4. https://doi.org/10.1016/j.jaci.2009.06.038

    Article  PubMed  Google Scholar 

  5. van Kampen V, de Blay F, Folletti I, Kobierski P, Moscato G, Olivieri M, Quirce S, Sastre J, Walusiak-Skorupa J, Raulf-Heimsoth M. EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies. Allergy. 2013;68(5):580-584. https://doi.org/10.1111/all.12120

    Article  PubMed  Google Scholar 

  6. Calzada D, Aranda T, M Gallego G, Escutia MR, Balsa D, Álvarez J, Mayorga C, Salas M, Odena MA, Oliveira E, Pascal M, Carnés J. Immunological mechanisms involved in the human response to a dog dander allergoid. Mol. Immunol. 2022;145:88-96. https://doi.org/10.1016/j.molimm.2022.02.020

  7. Aalberse RC, Crameri R. IgE-binding epitopes: a reappraisal. Allergy. 2011;66(10):1261-1274. https://doi.org/10.1111/j.1398-9995.2011.02656.x

    Article  CAS  PubMed  Google Scholar 

  8. Polovic N, Wadén K, Binnmyr J, Hamsten C, Grönneberg R, Palmberg C, Milcic-Matic N, Bergman T, Grönlund H, van Hage M. Dog saliva-an important source of dog allergens. Allergy. 2013;68(5):585-592. https://doi.org/10.1111/all.12130

    Article  CAS  PubMed  Google Scholar 

  9. Ukleja-Sokołowska N, Gawrońska-Ukleja E, Żbikowska-Gotz M, Socha E, Lis K, Sokołowski Ł, Kuźmiński A, Bartuzi Z. Analysis of feline and canine allergen components in patients sensitized to pets. Allergy Asthma Clin. Immunol. 2016;12:61. https://doi.org/10.1186/s13223-016-0167-4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Calamelli E, Liotti L, Beghetti I, Piccinno V, Serra L, Bottau P. Component-Resolved Diagnosis in Food Allergies. Medicina (Kaunas). 2019;55(8):498. https://doi.org/10.3390/medicina55080498

    Article  PubMed  PubMed Central  Google Scholar 

  11. Uriarte SA, Sastre J. Clinical relevance of molecular diagnosis in pet allergy. Allergy. 2016;71(7):1066-1068. https://doi.org/10.1111/all.12917

    Article  CAS  PubMed  Google Scholar 

  12. Madhurantakam C, Nilsson OB, Uchtenhagen H, Konradsen J, Saarne T, Högbom E, Sandalova T, Grönlund H, Achour A. Crystal structure of the dog lipocalin allergen Can f 2: implications for cross-reactivity to the cat allergen Fel d 4. J. Mol. Biol. 2010;401(1):68-83. https://doi.org/10.1016/j.jmb.2010.05.043

    Article  CAS  PubMed  Google Scholar 

  13. Apostolovic D, Sánchez-Vidaurre S, Waden K, Curin M, Grundström J, Gafvelin G, Cirkovic Velickovic T, Grönlund H, Thomas WR, Valenta R, Hamsten C, van Hage M. The cat lipocalin Fel d 7 and its cross-reactivity with the dog lipocalin Can f 1. Allergy. 2016;71(10):1490-1495. https://doi.org/10.1111/all.12955

    Article  CAS  PubMed  Google Scholar 

  14. Lei DK, Grammer LC. An overview of allergens. Allergy Asthma Proc. 2019;40(6):362-365. https://doi.org/10.2500/aap.2019.40.4247

    Article  CAS  PubMed  Google Scholar 

  15. Caraballo L, Valenta R, Puerta L, Pomés A, Zakzuk J, Fernandez-Caldas E, Acevedo N, Sanchez-Borges M, Ansotegui I, Zhang L, van Hage M, Abel-Fernández E, Karla Arruda L, Vrtala S, Curin M, Gronlund H, Karsonova A, Kilimajer J, Riabova K, Trifonova D, Karaulov A. The allergenic activity and clinical impact of individual IgEantibody binding molecules from indoor allergen sources. World Allergy Organ. J. 2020;13(5):100118. https://doi.org/10.1016/j.waojou.2020.100118

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Breitenbuecher C, Belanger JM, Levy K, Mundell P, Fates V, Gershony L, Famula TR, Oberbauer AM. Protein expression and genetic variability of canine Can f 1 in golden and Labrador retriever service dogs. Canine Genet. Epidemiol. 2016;3:3. https://doi.org/10.1186/s40575-016-0031-3

    Article  PubMed  PubMed Central  Google Scholar 

  17. Nicholas C, Wegienka G, Havstad S, Zoratti E, Ownby D, Johnson CC. Dog characteristics and allergen levels in the home. Ann. Allergy Asthma Immunol. 2010;105(3):228-233. https://doi.org/10.1016/j.anai.2010.06.019

    Article  PubMed  PubMed Central  Google Scholar 

  18. Mäntyjärvi R, Rautiainen J, Virtanen T. Lipocalins as allergens. Biochim. Biophys. Acta. 2000;1482(1-2):308-317. https://doi.org/10.1016/s0167-4838(00)00139-4

    Article  PubMed  Google Scholar 

  19. Clayton GM, White J, Lee S, Kappler JW, Chan SK. Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6. PLoS One. 2019;14(9):e0213052. https://doi.org/10.1371/journal.pone.0213052

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Jensen-Jarolim E, Pacios LF, Bianchini R, Hofstetter G, Roth-Walter F. Structural similarities of human and mammalian lipocalins, and their function in innate immunity and allergy. Allergy. 2016;71(3):286-294. https://doi.org/10.1111/all.12797.

    Article  CAS  PubMed  Google Scholar 

  21. Pandjaitan B, Swoboda I, Brandejsky-Pichler F, Rum-pold H, Valenta R, Spitzauer S. Escherichia coli expression and purification of recombinant dog albumin, a cross-reactive animal allergen. J. Allergy Clin. Immunol. 2000;105(2, Pt 1):279-285. https://doi.org/10.1016/s0091-6749(00)90077-0

  22. Chruszcz M, Mikolajczak K, Mank N, Majorek KA, Porebski PJ, Minor W. Serum albumins-unusual allergens. Biochim. Biophys. Acta. 2013;1830(12):5375-5381. https://doi.org/10.1016/j.bbagen.2013.06.016

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Spitzauer S, Schweiger C, Sperr WR, Pandjaitan B, Valent P, Mühl S, Ebner C, Scheiner O, Kraft D, Rumpold H, Valenta R. Molecular characterization of dog albumin as a cross-reactive allergen. J. Allergy Clin. Immunol. 1994;93(3):614-627. https://doi.org/10.1016/s0091-6749(94)70073-7

    Article  CAS  PubMed  Google Scholar 

  24. Liccardi G, Calzetta L, Salzillo A, Apicella G, Piccolo A, Di Maro E, Rogliani P. Dog allergy: can a prevalent or exclusive sensitization to Can f 5 be considered a lucky or negative event in real life? Eur. Ann. Allergy Clin. Immunol. 2018;50(6):283-285. https://doi.org/10.23822/EurAnnACI.1764-1489.41

  25. Mattsson L, Lundgren T, Everberg H, Larsson H, Lidholm J. Prostatic kallikrein: a new major dog allergen. J. Allergy Clin. Immunol. 2009;123(2):362-368. https://doi.org/10.1016/j.jaci.2008.11.021

    Article  CAS  PubMed  Google Scholar 

  26. Niemi MH, Rytkönen-Nissinen M, Jänis J, Virtanen T, Rouvinen J. Structural aspects of dog allergies: the crystal structure of a dog dander allergen Can f 4. Mol. Immunol. 2014;61(1):7-15. https://doi.org/10.1016/j.molimm.2014.04.003

    Article  CAS  PubMed  Google Scholar 

  27. González-de-Olano D, Gandolfo-Cano M, de-Calzada-Bustingorri MP, González-Mancebo E, de-Andrés-Martín A, Cuesta-Herranz J, Bartolomé-Zavala B, Pastor-Vargas C. Prevalence of allergy to human seminal fluid among women with allergy to male dog and sensitization to Can f 5. Clin. Exp. Allergy. 2018;48(10):1368-1370. https://doi.org/10.1111/cea.13226

  28. Tanaka M, Nakagawa Y, Kotobuki Y, Katayama I. A case of human seminal plasma allergy sensitized with dog prostatic kallikrein, Can f 5. Allergol. Int. 2019;68(2):259-260. https://doi.org/10.1016/j.alit.2018.08.003

    Article  PubMed  Google Scholar 

  29. Ukleja-Sokołowska N, Lis K, Żbikowska-Gotz M, Adamczak R, Bartuzi Z. Analysis of allergen profile in patients sensitized to canine allergen and potential Can f 5 cross-reactivity with human PSA. Int. J. Immunopathol. Pharmacol. 2021;35:20587384211023670. https://doi.org/10.1177/20587384211023670

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Fall T, Ekberg S, Lundholm C, Fang F, Almqvist C. Dog characteristics and future risk of asthma in children growing up with dogs. Sci. Rep. 2018;8(1):16899. https://doi.org/10.1038/s41598-018-35245-2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Fernández-Caldas E, Cases B, El-Qutob D, Cantillo JF. Mammalian raw materials used to produce allergen extracts. Ann. Allergy Asthma Immunol. 2017;119(1):1-8. https://doi.org/10.1016/j.anai.2016.08.024

    Article  CAS  PubMed  Google Scholar 

  32. Jeon H, Jung JH, Kim Y, Kwon Y, Kim ST. Allergen Microarrays for In vitro Diagnostics of Allergies: Comparison with ImmunoCAP and AdvanSure. Ann. Lab. Med. 2018;38(4):338-347. https://doi.org/10.3343/alm.2018.38.4.338

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. van Hage M, Hamsten C, Valenta R. ImmunoCAP assays: Pros and cons in allergology. J. Allergy Clin. Immunol. 2017;140(4):974-977. https://doi.org/10.1016/j.jaci.2017.05.008

    Article  CAS  PubMed  Google Scholar 

  34. Keshavarz B, Platts-Mills TAE, Wilson JM. The use of microarray and other multiplex technologies in the diagnosis of allergy. Ann. Allergy Asthma Immunol. 2021;127(1):10-18. https://doi.org/10.1016/j.anai.2021.01.003

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Westwood M, Ramaekers B, Lang S, Armstrong N, Noake C, de Kock S, Joore M, Severens J, Kleijnen J. ImmunoCAP® ISAC and Microtest for multiplex allergen testing in people with difficult to manage allergic disease: a systematic review and cost analysis. Health Technol. Assess. 2016;20(67):1-178. https://doi.org/10.3310/hta20670

    Article  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    E. M. Kozlov, A. A. Dubovets, K. A. Ryabova, A. R. Galashin, A. R. Levshina, A. V. Karsonova & A. V. Karaulov

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  1. E. M. Kozlov
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  2. A. A. Dubovets
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  3. K. A. Ryabova
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  6. A. V. Karsonova
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  7. A. V. Karaulov
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Correspondence to A. V. Karaulov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 6, pp. 664-669, June, 2023

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Kozlov, E.M., Dubovets, A.A., Ryabova, K.A. et al. Modern Concept of Molecular Diagnostics of Allergy to Dogs. Bull Exp Biol Med 175, 715–719 (2023). https://doi.org/10.1007/s10517-023-05932-w

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