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Morphological Features of the Ascending Aorta Remodeling and Activation of Regeneratory Potential in Intima when Forming Aneurysm

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Bulletin of Experimental Biology and Medicine Aims and scope

In patients with an ascending aorta aneurysm, restructuring of all its layers and, first of all, the intima and media was revealed. The thickness of the intima was 79.3±63.1 μm in patients with aortic diameter <55 mm (group Ao<55) and 162.7±177.4 μm (p<0.05) in patients with aortic diameter ⩾55 mm (Ao⩾55 group), the thickness of the aortic media was 1184.0±198.2 and 1144.3±288.4 μm, respectively. In patients of the Ao<55 group, aortic dilatation was accompanied by compensatory thickening of the inner and middle layers of the aorta. In the Ao⩾55 group, thinning of the aortic media, fragmentation of elastic fibers, and its cystic degeneration were revealed. c-kit+ Stem cells were detected in the subendothelium of the thickened intima of the dilated ascending aorta. The appearance of c-kit+ cells correlated with intimal remodeling and its colonization with CD34+ and CD44+ myofibroblast-like cells.

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Authors and Affiliations

  1. A. N. Bakulev National Medical Research Center of Cardiovascular Surgery, Ministry of Health of the Russian Federation, Moscow, Russia

    T. V. Sukhacheva, E. V. Penyaeva, M. A. Soborov, S. V. Garmanov, S. V. Rychin, V. A. Mironenko & R. A. Serov

  2. I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

    M. A. Soborov

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  1. T. V. Sukhacheva
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  2. E. V. Penyaeva
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  6. V. A. Mironenko
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Correspondence to T. V. Sukhacheva.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 1, pp. 52-61, March, 2023

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Sukhacheva, T.V., Penyaeva, E.V., Soborov, M.A. et al. Morphological Features of the Ascending Aorta Remodeling and Activation of Regeneratory Potential in Intima when Forming Aneurysm. Bull Exp Biol Med 175, 162–171 (2023). https://doi.org/10.1007/s10517-023-05829-8

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